Senior Associate Scientist, Analytical Development

At Bristol Myers Squibb, our employees often ask, \"Who are you working for?\"-a question that fuels collaboration, accountability, and urgency in our work. Our purpose-driven culture inspires us to discover, develop, and deliver innovative medicines to prevail over serious diseases. We offer uniquely interesting and meaningful work, opportunities for growth, and a supportive environment that values inclusion, wellbeing, flexibility, and comprehensive benefits. This is work that transforms the lives of patients, and the careers of those who do it. BMS at Kendall Square is seeking a highly skilled and motivated Senior Associate Scientist with strong expertise in analytical method development to support the advancement of novel RNA therapeutics. The successful candidate will leverage biophysical and separation techniques to design, develop, and execute analytical methods that enable comprehensive characterization of lipids, antibodies, and RNA-based modalities across discovery and development stages. This role will play a critical part in generating high-quality analytical data to support product understanding, process development, and CMC strategies. Responsibilities Independently design, develop, and optimize analytical methods to characterize RNA-based therapeutics, lipid nanoparticles, and related components. Support routine and platform analytical testing across safety, identity, content, purity/impurity, potency, and general quality attributes for LNP-encapsulated RNA. Lead phase-appropriate method lifecycle activities, including method development, qualification, validation, and transfer to internal and external laboratories (e.g., CROs/CDMOs), with authorship of SOPs, protocols, and technical reports. Collaborate cross-functionally with process development, formulation, research, and manufacturing teams to support analytical development, troubleshoot issues, and enable program milestones and timelines. Troubleshoot complex analytical challenges, interpret data, and provide scientifically sound recommendations to resolve issues and improve assay performance and robustness. Perform and oversee routine and non-routine analytical testing, including data review, verification, and interpretation to ensure data quality, integrity, and compliance with internal standards. Operate, maintain, and troubleshoot analytical instrumentation. Analyze and communicate complex analytical data, generating clear, concise reports and presentations to inform technical teams and leadership decisions undefined Qualifications B.S./M.S. in Analytical Chemistry, Biochemistry, or a related discipline with 2+ years of relevant CMC-related experience. PhD. candidates with appropriate experience will be considered for this position. Hands-on experience with HPLC/UHPLC (IP-RP, RP, CAD detection) for RNA, lipid, and impurity quantitation. Hands-on experience with biophysical/biochemical characterization techniques: DLS, RiboGreen, ELISA, Raman spectroscopy, light/confocal microscopy, UV-Vis spectrophotometry. Ability to manage multiple projects and priorities in a fast-paced environment. Strong technical writing skills for reports, protocols, and regulatory documentation. Familiarity with regulatory expectations (e.g., ICH, FDA) for analytical data and submissions. We hire for skills and capabilities, not just credentials, Compensation Overview Cambridge - MA - US: $94,400 - $114,392 The starting pay range(s) listed above is for full-time employees (FTE). You may also be eligible for additional discretionary incentive cash and stock opportunities. We determine starting pay thoughtfully - carefully considering the nature of the role, required skills, work location, schedule and the knowledge and experience you bring. Final compensation is guided by pay equity principles and applicable employment laws. Compensation programs are reviewed on an ongoing basis and may be adjusted over time to reflect evolving market factors, and individual, team or Company performance. Benefits Subject to the terms and conditions of the applicable plans then in effect, you may be eligible to participate in our comprehensive benefit plans - including wellbeing support, retirement and financial protection benefits, and insurance offerings (medical, dental, vision, life and disability). U.S.-based exempt employees are eligible for Flexible Time Off (FTO), which provides paid time off without a set accrual limit, subject to manager approval, along with 11 paid company holidays each year. Non-exempt employees, RayzeBio employees, and employees located in Puerto Rico receive 160 hours of paid vacation annually for new hires (subject to manager approval), 11 paid company holidays, and 3 optional holidays. Depending on eligibility, employees may also have access to additional time-off benefits, including paid sick leave, up to two paid volunteer days per year, summer hours flexibility, and leaves of absence for medical, personal, parental, caregiver, bereavement, or military needs. Eligible employees also enjoy an annual Global Shutdown between Christmas Day and New Year's Day. U.S.-based job seekers can explore full benefit offerings at How We Work Where you work matters - because collaboration, innovation and patient impact happen in many settings. Our roles are structured across four work models: site-essential, site-by-design, field-based and remote-by-design. The model assigned to this role is based on its core responsibilities. 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We’re also nurturing our own diverse team with inspiring work and challenging career options. No matter the role, each one of us makes a contribution. And that makes all the difference. #J-18808-Ljbffr Bristol-Myers Squibb Co