Director of Project Management Office, Cell Therapy Technical Operations

Position Summary The Director of Project Management Office, Cell Therapy Technical Operations is a highly strategic leadership role responsible for establishing, digitizing, and leading the operations branch of the centralized Cell Therapy Technical Operations (CTTO) PMO. This leader will set up the PMO’s ways of working across CTTO with the ultimate vision of building a PM-enabled, self‑sufficient organization. Reporting into the CMC Portfolio Strategy Cell Therapy organization, the role will oversee high‑value Technical and Operational Projects while simultaneously establishing the standard project management framework, governance, tools, and best practices to be utilized across all tiers of the CTTO projects portfolio. By leveraging artificial intelligence and digital automation aligned with AstraZeneca’s 2030 ambition, this role will empower technical leaders to manage projects independently, utilizing dedicated PMO resources primarily for complex initiation and planning phases. This position is based in Gaithersburg, MD. Responsibilities Strategic Project Execution: Directly manage or oversee the execution of complex, highly cross‑functional above‑site projects ensuring on‑time and on‑budget delivery. Portfolio Visibility & Tracking: Develop, implement, and maintain a centralized, real‑time portfolio dashboard capturing all active projects across the CTTO organization, ensuring full transparency of organizational demand, resources, and strategic alignment. PMO Vision & Self‑Sufficiency: Design and embed standard project management ways of working across CTTO to foster a PM‑enabled, self‑sufficient organization. Empower functional SMEs and leaders to act as independent Project Leads, requiring dedicated PMO support for critical lifecycle steps such as project initiation and complex planning. Digital Transformation & AI Integration: Develop, maintain, and continuously improve the PMO by leveraging cutting‑edge digital solutions and artificial intelligence in alignment with AstraZeneca’s 2030 ambition. Partner directly with IT to design, test, and implement custom AI tools and automation strategies that streamline project management workflows. Standardization & Best Practices: Act as the authoritative voice for project management methodology within CTTO. Design, deploy, and govern standardized, highly automated tools (e.g., Project Charters, RAID logs, unified RAG dashboards) to ensure uniform, efficient ways of working across all project tiers. Governance: Partner with the CTTO Leadership Team acting as the Project Review Committee (PRC). Facilitate governance meetings to drive data‑backed, Go/No‑Go decisions, manage capacity forecasting, prioritize resource allocation, and rapidly resolve escalated project risks. Cross‑Functional Community of Practice: Foster a collaborative relationship with the internal CMC PM team to build a unified Community of Practice. Lead outward‑facing networking by engaging with enterprise PM communities outside of CTDO, influencing broader AstraZeneca standards, and integrating industry‑leading digital practices back into the organization. Supervisory Responsibilities Team Leadership: Provides direct line management to a targeted team of Cell Therapy Project Managers and external contractors deployed for peak portfolio demand or specialized planning phases. Talent Cultivation: Cultivates talent through coaching, professional development, and succession planning. Ensures the team builds the necessary matrix leadership skills, digital fluency, and strategic execution capabilities required to drive complex business objectives. Escalation Management: Leads formal issue escalation and resolution in partnership with the matrix team, sponsors, and the Project Review Committee (PRC). Essential Requirements Education: Bachelor’s degree in Life Sciences, Engineering, or a relevant technical field required. Master’s degree or MBA is highly preferred. Experience: 10+ years of experience in the pharmaceutical, biotech, or Cell Therapy industry, with at least 8+ years specifically in project, program, or portfolio management. Leadership: Proven experience managing direct reports and leading PMOs or shared‑service project teams within a complex, highly matrixed environment. Technical Acumen: Deep operational understanding of cell therapy supply chain, vein‑to‑vein logistics, network capacity, and cGMP/regulatory requirements. Methodologies & Tools: Advanced proficiency in portfolio management software (e.g., Smartsheet, MS Project, Agile). Active PMP certification required, with Lean Six Sigma highly desired. Communication & Influencing Skills: Outstanding written, interpersonal, and executive‑level presentation skills. Must possess the ability to distill complex operational data into clear, compelling narratives to effectively influence senior leadership, drive alignment, and foster collaboration across diverse stakeholder groups. Change Management: Drive change management across organizational levels, and reset cultural expectations regarding project governance and resource allocation. Digital & AI Fluency: Tech‑savvy and avid practitioner of digital automation and AI tools highly preferred. Proven experience working alongside IT departments to develop and implement digital or AI‑driven solutions specifically for operational or project portfolio management is a plus. Travel: Willingness to travel occasionally for business purposes. Work Environment In‑person working gives us the platform we need to connect, work at pace, and challenge perceptions. We work, on average, a minimum of three days per week from the office, but we remain flexible and respect individual flexibility. Join us in our unique and ambitious world. Benefits The annual base pay for this position ranges from $149,806 to $224,708 USD per year. Hourly and salaried non‑exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job‑related knowledge, skills, and experience. In addition, our positions offer a short‑term incentive bonus opportunity; eligibility to participate in our equity‑based long‑term incentive program (salaried roles); a retirement contribution (hourly roles); and commission payment eligibility (sales roles). Benefits include a qualified retirement program (401(k) plan), paid vacation and holidays, paid leaves, and health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Equal Employment Opportunity AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry‑leading skills. We welcome and consider applications from all qualified candidates, regardless of their characteristics. We follow all applicable laws and regulations on non‑discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements. #J-18808-Ljbffr Dormont Manufacturing Co