Senior Associate Scientist, R&D Chemistry

Senior Associate Scientist, R&D Chemistry We are currently seeking a synthetic organic chemist for the R&D (Research & Development) Chemistry group. In this position, the successful candidate will support Regeneron’s small molecule antibody‑conjugate drug discovery capabilities, providing a link with the company’s expertise in biologics and novel genetic medicines. The role involves in‑house laboratory‑based synthetic chemistry activities to discover and generate novel small‑molecule payloads and linkers for antibody‑drug conjugate therapeutics across oncology, metabolic disease/obesity, infectious diseases, immunology and inflammation, neuroscience, and ophthalmology. Cultural fit with the Regeneron chemistry and cross‑functional teams is a priority. The R&D Chemistry team is composed of synthetic organic, medicinal chemistry, and bioconjugation scientists working in a highly collaborative environment with other technology, biology, and therapeutic area groups. Successful candidates will have a small‑molecule synthetic background and experience with retrosynthetic analysis, synthetic route design, and hands‑on execution of multistep synthetic protocols, including compound isolation and characterization. A firm understanding of modern organic synthesis strategies and techniques and the ability to work independently while deploying them in a fit‑for‑purpose, efficient approach to biologically active targets are required. The candidate must also interpret spectroscopic data for assignment and confirmation of small‑molecule structures. Knowledge of the latest synthetic methods used in antibody‑conjugate linker generation is a plus. Day in the Life of a Senior Associate Scientist, R&D Chemistry Perform day‑to‑day laboratory activities as part of the R&D Chemistry group, including experimental execution of small‑molecule syntheses and associated compound isolation and characterization. Troubleshoot, analyze data, interpret experimental results, and propose synthetic approaches to new targets. Discuss biological data and new targets within existing projects to address structure‑activity relationship directions. Identify new strategies and technologies best suited for synthetic execution of targets of interest. Work within the priorities set by cross‑functional teams and your supervisor to ensure successful progression of technology and pipeline projects. Participate in departmental and cross‑functional meetings to contribute expertise and represent the goals of the R&D Chemistry group. Interact broadly and collaboratively with other Regeneron groups. This Might Be The Right Role For You If You are passionate and enthusiastic about the promise of small‑molecule‑based, antibody‑targeted therapeutics and appreciate the challenges of synthetic chemistry and drug design. You enjoy developing solutions for synthesis and advancing structure‑activity relationships within medicinal chemistry drug discovery programs. You are comfortable working as part of a cross‑functional team. You want to be a part of an organizational culture that supports growth and development of its people and capabilities to drive the Regeneron pipeline. To Be Considered For This Role, You Must Hold an M.Sc. in synthetic organic chemistry (or related field) and be familiar with drug discovery processes and modern methods of synthetic organic and medicinal chemistry. Have a minimum of 5‑7 years of industry drug discovery experience with small molecules. Familiarity with peptidomimetics or antibody‑targeted therapeutics is a plus. Bonus experience includes a general understanding of the processes of biological target validation, ADME/PK, PD/efficacy, and the ways that medicinal chemistry contributes to progress in these areas. Regeneron is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion or belief, sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law. Where required, reasonable accommodations will be provided to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship. Salary Range (annually) $80,300.00 – $131,100.00 Salary ranges are disclosed for all countries in which we operate. The final offer will be determined within the relevant range based on the country of employment, specific role level, and your skills and experience. In some countries, collective bargaining agreements may apply. Regeneron offers a competitive and comprehensive total rewards package which may include annual bonuses or other incentive plans, equity awards, pension or retirement benefits, 401(k) company match, health and wellness programs, fitness centers, insurance benefits (medical, dental, vision, life, and disability), paid time off, and family support benefits. For additional information about Regeneron benefits in the U.S., please visit For other locations, additional information will be provided during the recruitment process. Please be advised that many roles are required to be performed onsite. Please speak with your recruiter and hiring manager for more information about onsite expectations for your role and location. As part of the recruitment process, certain background checks may be conducted in accordance with the laws of the country where the position is based, to verify identity, right to work, and educational qualifications. #J-18808-Ljbffr BioSpace