Director, Program Management Office

Alkermes is seeking a seasoned Program Manager to support our ALKS 4510 program, a key component of our orexin 2 receptor agonist portfolio strategy targeting fatigue associated with neurological disorders. The Program Manager will enable seamless execution of this dynamic development program by translating strategy into actionable plans, navigating complexity, and facilitating effective decision-making and delivery across the organization.The Program Manager leads through influence, serving as the focal point for cross-functional alignment and integrated execution. They manage the cross-functional product team, driving strategic and operational planning, communication, and governance as the program progresses through the stages of drug development. This role partners closely with Project Leaders and functional area representatives to synthesize plans, integrate activities, manage interdependencies, and mitigate risks, ensuring the program delivers maximum value and impact to the patients we serve and achieves key corporate objectives.We’re looking for an individual who values the team dynamic, is organizationally savvy, excels in a matrixed-management/leadership environment, and thrives at connecting detailed execution with strategic priorities. Alkermes has recently adopted a hybrid working environment to support and meet the needs of employees and this role will operate in a flexible environment with 60% of time in the office and 40% from home. This position is eligible for the hybrid workplace model, requiring work to be completed onsite at our Waltham, MA office at least 3 days per week. This role is not eligible for fully remote work.Why join Team Alkermes?Alkermes applies its decades of deep neuroscience expertise to develop medicines designed to help people living with complex and difficult-to-treat psychiatric and neurological disorders. A global biopharmaceutical company, headquartered in Ireland with U.S. locations in Massachusetts and Ohio, we seek to make a meaningful difference in the way people manage their diseases. We have a portfolio of proprietary commercial products for the treatment of alcohol dependence, opioid dependence, schizophrenia, bipolar I disorder and narcolepsy, and a pipeline of clinical and preclinical candidates in development for various psychiatric and neurological disorders.We are proud to have been recognized as an employer of choice by many national organizations. In 2024 and 2025, we were certified as a Great Place to Work in the U.S. and named one of Massachusetts’ Top Places to Work by the Boston Globe, a Best Place to Work in Greater Cincinnati by the Cincinnati Business Courier and recognized as a Best Place to Work in BioPharma by Fortune Magazine. Alkermes, Inc. is an equal employment opportunity employer and does not discriminate against any qualified applicant or employee because of race, creed, color, age, national origin, ancestry, religion, gender, sexual orientation, gender expression and identity, disability, genetic information, veteran status, military status, application for military service or any other characteristic protected by local, state or federal law. Alkermes also complies with all work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Alkermes is an E-Verify employer.Basic Requirements:BS/MS in a scientific or engineering discipline, with 12+ years of relevant pharmaceutical product development experienceExceptional verbal/written communication, time/resource management, attention to detail, and interpersonal and organization skills Preferred Requirements:Prior experience managing cross-functional teams across the drug product lifecycle continuum from research through early-stage development and into late-stage developmentPrior experience maintaining program strategic plans and timelines with budgetary management responsibilityPrior experience working on regulatory documents, interactions and filingsExpert knowledge of MS Project (or equivalent), MS Excel, and MS PowerPointThe annual base salary for this position ranges from $212,000 to $240,000. In addition, this position is eligible for an annual performance pay bonus. Exact compensation may vary based on skills, training, knowledge, and experience. Alkermes offers a competitive benefits package. Additional details can be found on our careers website: #LI-HBiFacilitating development and execution of integrated program strategic and operational plans, including:Identification and monitoring of critical program goals, activities, and cross-functional linkagesOptimization of plans by challenging assumptions, evaluating opportunities to address constraints and gaps, and incorporating of new inputs as the program progressesProactive discussion and management of potential risk areas, including endorsement and implementation of aligned mitigation and/or contingency plansProviding strong project and program management support to the product team and key sub-teams by:Managing and facilitating meetings with proactive agenda planning and well-documented minutes, designed to support effective planning, problem solving and alignmentDeveloping and maintaining program budgets, timelines, and reporting tools/documents used by the team and senior management to ensure effective coordination, transparent and open communication, and disciplined governanceCultivating an enterprise mindset within the team and driving strong cross-functional prioritization and decision makingLeading with an innovative, solution-oriented approach to ensure issues are resolved and communicated/escalated as neededContributing to enhancement and innovation of our program management systems, tools, and processes to support the evolving needs of our teams and the broader businessFull timePosting Date: 2026-08-17