Vice President of Sales, Oncology

A Rare Opportunity to Shape the Future of Genomics

Join a team of brilliant, passionate innovators determined to transform healthcare. At BillionToOne, we've built a category-defining, publicly traded company on Nasdaq where transparency fuels trust, collaboration drives breakthroughs, and every contribution moves the needle on our mission to make life-changing diagnostics accessible to all. We don't just aim for incremental improvements; we build products that are 10x better than anything that exists today.

Our scientists, engineers, sales executives, and visionaries are united by an unwavering commitment to changing the standard of care in prenatal and cancer diagnostics. This is where cutting-edge science meets human compassion, and every innovation you contribute helps remove the fear of the unknown from some of life's most critical medical moments.

If you're driven by purpose, energized by innovation, and ready to help shape the future of precision medicine at scale, this is where you belong.

BillionToOne is a precision diagnostics company built on a proprietary molecular counting platform that detects and quantifies DNA with exceptional sensitivity. Our oncology portfolio, including Northstar®, our liquid biopsy test for comprehensive genomic profiling and treatment response monitoring, is a core pillar of our growth. We are scaling our commercial organization to bring Northstar to more oncologists and more patients.

The Vice President of Oncology Sales owns the commercial oncology sales function. You will lead a multi-layer field organization that has grown to nearly 100 representatives, working through Directors and the Managers beneath them. You will set the sales strategy and operating cadence and be accountable for revenue, test volume, market share, and the quality of the team we build.

You will be a member of the Executive Leadership Team and report directly to the Chief Executive Officer. You will partner closely with Marketing, Medical Affairs, Market Access and Reimbursement, Commercial Operations, Customer Experience and Finance to turn clinical differentiation into durable commercial results.

Responsibilities:

• Own the oncology revenue and volume plan. Deliver against annual and quarterly targets and forecast with discipline and accuracy.
• Lead, coach and develop a multi-layer sales team, including Directors and the Managers beneath them, Oncology Specialists, and any specialty or account-based roles.
• Design and continuously refine territory structure, segmentation, targeting and account coverage models across community oncology, academic centers, integrated health systems and key accounts.
• Build and operate a rigorous sales management system: pipeline reviews, KPIs, call-plan and activity standards, performance management and recognition programs.
• Set the hiring bar and run the talent strategy: recruit, onboard and retain top oncology diagnostics talent, and build leadership succession at the Director and Manager levels.
• Partner with Commercial Operations on incentive compensation, quotas, sales analytics, CRM and field enablement.
• Partner with Marketing and Medical Affairs on launch sequencing, messaging, KOL strategy and the clinical evidence that supports adoption.
• Partner with Market Access and Revenue Cycle teams to improve payer coverage, reimbursement outcomes and the customer experience.
• Build and maintain relationships with key opinion leaders, major cancer centers, health systems and strategic accounts.
• Track the liquid biopsy and MRD competitive landscape and turn market intelligence into winning plays.
• Report on market trends, competitive dynamics and sales performance to senior leadership, and represent BillionToOne at oncology conferences, customer events and advisory forums.

Qualifications:

• 15+ years of sales experience in diagnostics, with deep, hands-on oncology diagnostics experience (molecular, genomic profiling, liquid biopsy, MRD/monitoring).
• 7+ years leading sales organizations, including Director-level leaders and a multi-layer field team.
• Demonstrated record of exceeding revenue goals and growing market share in a competitive oncology diagnostics market.
• Direct experience scaling a commercial team through a growth phase or major product launch.
• Strong command of oncology buying dynamics: medical oncologists, pathologists, practice administrators, health systems, and the role of reimbursement in adoption.
• Proven ability to build, develop and retain high-performing leaders, through both internal promotion and external recruiting.
• Working fluency with sales operations: territory design, incentive compensation, forecasting, CRM and field analytics.
• Bachelor’s degree.

Leadership Attributes

• Operator and builder: comfortable with both strategy and the weekly rhythm of running a large field force, with a “no job too big or too small” attitude.
• Talent magnet: known in the industry for attracting and developing top reps and leaders, with a genuine people-first approach.
• Data-driven and candid: decides with metrics, communicates directly, and holds self and others accountable while keeping team morale high.
• Cross-functional partner: earns trust with Medical, Marketing, Operations, Finance and Scientific leadership.
• Resilient and urgent: thrives in a fast-growing, high-expectation environment, with a bias toward action.
• Humble: free from ego, not seeking the personal spotlight, and committed to the mission of transforming cancer care.

Additional Details:

• Location: Flexible within the US
• Travel Requirements: Approximately 50%, including field work, cancer center visits, headquarters visits and quarterly manager meetings

Benefits And Perks:

• Working alongside brilliant, kind, passionate and dedicated colleagues, in an empowering environment, toward a global vision, striving for a future in which transformative molecular diagnostics can help millions of patients
• Open, transparent culture that includes weekly Town Hall meetings
• The ability to indirectly or directly change the lives of hundreds of thousands patients
• Multiple medical benefit options; employee premiums paid 100% of select plans, dependents covered up to 80%
• Extremely generous Family Bonding Leave for eligible employees (16 weeks, paid at 100%)
• Supplemental fertility benefits coverage
• Retirement savings program including a 4% Company match
• Increase paid time off with increased tenure
• Latest and greatest hardware (laptop, lab equipment, facilities)

At BillionToOne, we are proud to offer a combination of a (1) base pay + uncapped commissions (2) generous equity options offering, on top of (3) industry leading company benefits (free healthcare options, 401k match, very generous fully paid parental leave, etc.).

For this position, the base salary is up to $300,000 + commission, equity and a monthly car allowance.

BillionToOne is an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

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BillionToOne is a next-generation molecular diagnostics company on a mission to make powerful, accurate diagnostic tests accessible to everyone. Our revolutionary QCT molecular counting technology enhances disease detection resolution by over a thousandfold using cell-free DNA,a breakthrough that has already transformed the lives of over half a million patients worldwide.

Our Impact

Unity Complete™ is the only non-invasive prenatal screen capable of assessing fetal risk for both common recessive conditions and aneuploidies from a single maternal blood sample.
Unity Confirm™ enables non-invasive confirmation for high-risk screening results through the capture of intact circulating fetal cells using BillionToOne’s Fetal Cell Capture™ Technology.
Our Northstar® liquid biopsy test uniquely combines treatment selection with real-time monitoring, giving oncologists unprecedented precision in cancer care.

Our Growth

From $0 to $400M+ annualized revenue run-rate in just 6 years. In 2025, we completed one of the most successful IPOs for a medical diagnostics company, building on nearly $400M in private funding,including our $130M Series D in 2024 and backed by world-class investors including Hummingbird, Adams Street Partners, Neuberger Berman, Baillie Gifford, and Premji Invest.

Our Recognition

Forbes named us one of America's Best Startup Employers for 2025 and we're Great Place to Work certified , with 100% of our people willing to go the extra mile, even as we've scaled to over 700 employees.

Our Future

Headquartered in Menlo Park with facilities in Union City, CA, and a new lab opening in Austin, TX in 2027, we're continuing to push the boundaries of what's possible in molecular diagnostics. We're just getting started.

Ready to help us change the world, one molecule at a time? Learn more at billiontoone.com