Sign up to access all features of our service.
  • Job search
  • Favorites
  • Create a CV
    New
  • Salaries
  • Subscriptions

Senior Program Manager, Program Leadership and Management

$143k - $197k
Full-time

Deciphera Pharmaceuticals

Company Description

Deciphera, a member of Ono Pharmaceutical Co., Ltd., is a biopharmaceutical company focused on discovering, developing, and commercializing important new medicines and providing hope to people living with cancer, neurologic and autoimmune disease. Deciphera is leveraging its proprietary switch-control kinase inhibitor platform and deep expertise in kinase biology to develop a broad portfolio of innovative medicines. In addition to advancing multiple product candidates from Deciphera’s platform in clinical studies, QINLOCK® (ripretinib) is Deciphera’s switch-control kinase inhibitor approved in many countries including the European Union and the United States for the treatment of adult patients with advanced gastrointestinal stromal tumor (GIST) who have received prior treatment with 3 or more kinase inhibitors, including imatinib. ROMVIMZA® (vimseltinib) is a kinase inhibitor approved in the United States for adult patients with symptomatic tenosynovial giant cell tumor (TGCT) for which surgical resection will potentially cause worsening functional limitation or severe morbidity, and in the European Union for adult patients with TGCT associated with clinically relevant physical function deterioration and in whom surgical options have been exhausted or would induce unacceptable morbidity or disability.

The spirit of collaboration that has brought medications to life continues to guide how we operate, grow, and discover new breakthroughs. We cultivate an inclusive culture that values curiosity, creativity, and shared accountability—empowering individuals to challenge the unknown together.

Deciphera offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

Job Description

We are seeking a dynamic Sr. Program Manager, Program Leadership & Management, to provide leadership, strategic direction and program management to our Development and Commercial Program Teams. In partnership with the Program Lead, the Sr Program Manager will drive development and deliver results for programs in early to late phase clinical development and/or lifecycle management programs. The successful candidate should possess and demonstrate a firm understanding of drug development, be comfortable with ambiguity, and have strong communication skills, enabling effective communication within program teams and throughout the organization.

This role is highly cross-functional and will involve collaboration with internal and potentially external partners. In partnership with the Program Lead, the Sr. Program Manager is charged with leading daily program management activities, including the development and execution of the program’s Integrated Development Strategy. He/she/they is expected to have an understanding of the overall program strategy and critical path activities, including risks and potential mitigation plans.

Key Responsibilities:

  • Strategic partner to the Program Lead, enabling development and ensuring execution of the Integrated Development Strategy- 50%
    • In partnership with the Program Lead, drives the development and execution of strategic, integrated development plans through effective leadership of Program Teams
    • Provides clear direction on product development requirements to meet the expectations of external customers and business stakeholders
    • Monitors program progress and related KPIs, identifies gaps and risks and makes strategic recommendations
    • Supports the execution and continuous re-assessment of development strategy in support of the overarching corporate strategy
  • Ensures the effective and consistent operation of high-functioning program teams – 50%
    • Facilitates program team meetings to ensure productive and efficient discussion
    • Ensures clear and timely communication of program strategy and progress to relevant stakeholders
    • Orchestrates the integration of sub-teams to support the effectors of Program Teams

Qualifications

  • Bachelor’s with 8+ years of R&D and/or drug development project management experience
  • Strong organizational and communication skills
  • Knowledge of/exposure to the drug development process
  • Knowledge of project management software/tools
  • Ability to manage team dynamics and handle multiple projects

Preferred Capabilities

  • Experience supporting a clinical trial
  • Experience in developing drugs for oncology, neurology and/or orphan diseases

Additional Information

Deciphera is committed to fair and equitable compensation practices. The base salary pay range for this role is $143,000 - $197,000. Actual compensation packages will depend on various factors, including, but not limited to depth of experience, education, skillset, overall performance and/or location.​

Deciphera believes in providing a competitive compensation and benefits package to all employees. Our base salary is just one component of Deciphera’s competitive total rewards strategy that also includes annual performance bonus, a long-term incentive plan, full range of benefits and other incentive compensation plans (if applicable)

Benefits:

  • Competitive salary and annual bonus.
  • Comprehensive benefits package including medical, dental, vision insurance, 401(k) retirement plan with company match, and more.
  • Generous parental leave and family planning benefits.
  • Outstanding culture and opportunities for personal and professional growth.

EQUAL EMPLOYMENT OPPORTUNITY INFORMATION

Deciphera is committed to equal employment opportunity and values diversity. To ensure that we comply with reporting requirements, we invite you complete the confidential survey at the end of this application. Providing this information is optional. It will not be accessible or used in the hiring process, and has no effect on your opportunity for employment. This information will also be treated confidentially. We are committed to make all hiring decisions and other employment decisions on a non-discriminatory basis.

Work Type: Full timeJob Location: On-Site Waltham
Vacancy posted a month ago
Similar jobs that could be interesting for youBased on the Senior Program Manager, Program Leadership and Management in Waltham, MA vacancy
  • Applied Research Solutions (ARS) seeks a Journeyman Program Manager to support the BACN program at Hanscom AFB, MA. The role requires non...  ...the ability to prepare briefing materials and summaries for leadership. Key duties include scheduling and staffing meetings,... 
    Senior

    Applied Research Solutions

    Bedford, MA
    4 days ago
  • Serco seeks a Program Manager SME for the AFLCMC/WAG portfolio, based at Wright Patterson AFB, OH. The role requires an active Top-Secret...  ...government and contractor teams. Strong strategic planning, leadership, and documentation skills are essential. #J-18808-Ljbffr... 
    Senior
    For contractors

    Serco

    Lincoln, MA
    1 day ago
  • $120k - $130k

     ...Job Description Job Description Overview   Senior Program Manager   WORK LOCATION :Hanscom AFB, MA   Salary Range :$120,00...  ...tight deadlines with changing priorities.   Possesses proven leadership, team building, strategic planning, and organizational... 
    Senior
    Full time

    Astrion

    Lexington, MA
    17 days ago
  • $140k - $155k

     ...Job Description Job Description Overview   SENIOR PROGRAM MANAGER   LOCATION:  Hanscom AFB, MA   SALARY RANGE : $140,000 -...  ...skills Ability to develop and present briefings to senior leadership Strong analytical and organizational skills Ability to... 
    Senior
    Full time
    For contractors
    Work at office

    Astrion

    Lexington, MA
    8 days ago
  • $166k - $220k

     ...Senior Technical Program Manager Anduril Industries is a defense technology company with a mission to transform U.S. and allied military capabilities...  ...and technical / programmatic reports to key leadership and the customer. ~ Willingness to travel ~ Currently... 
    Senior

    anduril

    Waltham, MA
    3 days ago
  •  ...Description McBride Consulting has an exciting opportunity for a Senior Program Manager providing support to the Command, Control, Communications,...  ..., graphics, and acquisition documentation for senior leadership Support source selection activities including... 
    Senior
    Full time
    For contractors
    Work at office

    McBride

    Lexington, MA
    8 days ago
  •  ...Therapeutics is seeking a seasoned Senior Director of Clinical...  ...to lead one or more clinical programs. The role reports to the Head...  ...execution of trials with global site management. They require 12+ years in...  ...in supervision, with strong leadership and regulatory knowledge. On-... 
    Senior

    City Therapeutics

    Cambridge, MA
    4 days ago
  •  ...Senior Technical Program Manager Watertown, MA September 9, 2026 Job Description The Company We believe general-purpose, generally-intelligent...  ...that grew without a decision. Write the status that leadership, engineering, and customer-facing teams read, in the... 
    Senior

    Venturefizz Product Management Community

    Watertown, MA
    2 days ago
  •  ...Systems has an exciting new opportunity for an experienced Senior Acquisition Program Manager supporting a high priority acquisition mission within...  ...and problem-solving abilities Team-oriented mindset with leadership experience Additional Information Location: Hanscom AFB... 
    Senior
    Contract work
    Work experience placement
    Live out

    Odyssey Systems Consulting Group, Ltd.

    Lincoln, MA
    3 days ago
  • $110k - $130k

    Overview Senior Contracting Program Manager LOCATION: Hanscom AFB, MA Salary Range: $110,000 - $130,000 annually* *depen ding on experience, certifications...  ...Ability to develop and present briefings to senior leadership Strong analytical and organizational skills Ability to... 
    Senior
    Full time
    Contract work
    For contractors

    Astrion

    Lincoln, MA
    2 days ago
  • Systems Planning and Analysis, Inc. (SPA) seeks a Program Manager to serve as the single main point of contact with the U.S. Air Force for all contract activities, owning cost, schedule, and technical performance. You will provide strategic direction and oversee planning... 
    Senior
    Contract work

    Systems Planning & Analysis

    Lincoln, MA
    4 days ago
  • $103.6k - $162.8k

     ...coordinated execution and measurable adoption across a portfolio of GTM programs. Product launches will be a core and recurring part of this...  ...(launch councils, readiness reviews, go/no-go checkpoints) Manage Alpha/Beta lifecycle in partnership with CS and Product for... 
    Senior
    Full time
    Live in
    Worldwide
    Shift work

    ZoomInfo Technologies LLC

    Waltham, MA
    2 days ago
  • LifeMine is seeking a Senior Director, Program Management to lead cross‑functional project management across our research, preclinical, and clinical...  ...Provide operational and strategic project management leadership to the cross-functional teams developing and commercializing... 
    Senior

    LifeMine

    Watertown, MA
    3 days ago
  • $114.48k - $170.07k

     ...Voyage – Apply Now Get to Know the Opportunity: As a Senior Program Manager, you will serve as the primary point of accountability for...  ...understand cost drivers, explain financial performance, and provide leadership with actionable insight. ~ Build trusted relationships... 
    Senior
    Full time
    Part time
    Work experience placement
    Local area
    Flexible hours

    Voya Financial

    Boston, MA
    4 days ago
  • $114k - $143k

     ...We offer a range of benefits, programs, and services to support our...  ...Position Summary The Sr. Program Manager is responsible for the...  ...clinical studies and reporting to senior management and shareholders...  ...project updates to senior leadership team ~ Proficient communications... 
    Senior
    Full time
    Live in
    Worldwide
    Flexible hours

    Sirtex

    Woburn, MA
    2 days ago
  • $120k - $140k

     ...Job Description Job Description Overview   Senior Program Manager   WORK LOCATION :Hanscom AFB, MA   Salary Range :$120,000-$140,000* *depen ding on experience, certifications, and qualifications   JOB STATUS: Full-time; Salaried Clearance:... 
    Senior
    Full time

    Astrion

    Lexington, MA
    11 days ago
  •  ...Senior Technical Program Manager AeroVect is transforming ground handling with autonomy, redefining how airlines and ground service providers...  ...cross-functional liaison between Engineering and Operations leadership Implement and maintain program governance standards —... 
    Senior

    AeroVect

    Boston, MA
    4 days ago
  •  ...We are seeking a strategic, highly organized event leader to program manage a portfolio of marquee internal corporate events that strengthen...  ...employee events. Partner with key stakeholders across leadership, Sales Enablement, HR, Sales, Service, Marketing, Communications... 
    Senior
    Work experience placement
    Summer work
    Work at office
    Flexible hours

    The MathWorks, Inc.

    Natick, MA
    4 days ago
  • $124k - $186k

    Senior Program ManagerProduct Operations — Lexington, MA, USMimecast is looking for a Senior Program Manager to drive our new features and products from readiness through market launch...  ...plans and visibility that make leadership confident every time.What You'll DoOwn... 
    Senior
    Full time
    Local area

    Mimecast

    Lexington, MA
    4 days ago
  • $130k - $145k

     ...Job Description Job Description Overview     SENIOR PROGRAM MANAGER   LOCATION:  Hanscom AFB, MA   SALARY RANGE : $130,000...  ...Microsoft Office Suite INTERPERSONAL SKILLS: Proven leadership skills with the ability to lead multiple efforts simultaneously... 
    Senior
    Full time
    For contractors
    Work at office
    Worldwide

    Astrion

    Lexington, MA
    4 days ago
  • $140k - $150k

     ...Job Description Job Description Overview SENIOR PROGRAM MANAGER LOCATION: Hanscom AFB, MA SALARY RANGE : $140,000 -$150,000 annually *depending on experience, certifications, and qualifications JOB STATUS: Full-time;salaried CLEARANCE:... 
    Senior
    Full time
    Contract work
    Work at office

    Astrion

    Lexington, MA
    a month ago
  •  ...and communities safe across every care setting. As the Sr. Program Manager for Infection Control focused on High-Level Disinfection & Sterilization...  ...program management experience required 1-2 years of team leadership experience required Certification in Infection Control (CIC... 
    Senior

    Mass General Brigham (Enterprise Services)

    Somerville, MA
    3 hours ago
  • $116.25k - $178.25k

     ...looking for a skilled and experienced individual to join the Program Management Office (PMO) and help support the execution of PathAI’s...  ...patients come first. The Opportunity - You will partner with senior leadership in the PMO and cross-functional technical experts, to help... 
    Senior
    Full time
    Work at office
    Relocation package

    Pathai

    Boston, MA
    5 days ago
  •  ...Engineering Program Manager – Advanced Product Development Work Type: Full-time, On-site Travel: 20–40% We are seeking an experienced Engineering...  ...technical detail into clear execution plans Demonstrated leadership in matrixed or fast-moving organizations Hands‑on role with... 
    Senior
    Full time
    Flexible hours

    Real Time Recruitment Solutions (RTRS)

    Boston, MA
    2 days ago
  • $126k - $170k

     ...Job Description Job Description STR is hiring a Senior Program Manager (PM) in the Cyber Division who is passionate about collaborative...  ...Interacting with external program customers and internal company leadership Managing scientists, engineers, and technicians across... 
    Senior
    Full time
    Contract work
    For subcontractor
    Work at office
    Local area
    Night shift

    STR

    Woburn, MA
    16 days ago
  • $109k - $142k

     ...technical foundation with proven project management or strategy expertise to effectively...  ...reports directed to shareholders, executive leadership, and the Board of Directors. Information...  ...firm, internal corporate strategy team, Program Management Office (PMO), or an... 
    Senior
    Work at office
    Monday to Thursday

    Motional

    Boston, MA
    4 days ago
  • Job title: Senior Program Manager - Mastocytosis Location: Cambridge, MA About The Job The Senior Program Manager (SPM) will drive business...  ...people's lives. Main Responsibilities Strategic Partnership & Leadership Lead program management initiatives for Mastocytosis in... 
    Senior
    Work at office
    Shift work

    BioSpace

    Cambridge, MA
    1 day ago
  • $233k - $285k

     ...The company is advancing clinical programs for Duchenne muscular dystrophy (DMD...  ...LinkedIn and Facebook. Role Summary The Senior Director, Program Management (PM) is a critical role within the...  ...with Program Team, Dyne Senior Leadership, and other stakeholders regarding... 
    Senior
    Temporary work
    Work at office
    Local area
    Remote work
    Shift work

    BioSpace

    Waltham, MA
    4 days ago
  •  ...Senior TPM of Applied AI AI is changing how the world communicates...  .... Rather than just managing timelines, you are architecting...  ...Entrepreneurial Benchmark Leadership: Act as the CEO of your customer...  ...objectives. Frontier Lab Program Management: Lead the end-to-end... 
    Senior
    Work at office

    Lilt

    Boston, MA
    2 days ago
  • $120k - $180k

     ...Technical Program Manager Do you want to change how the world creates? At Formlabs, we'...  ...program team, product stakeholders, and senior management, coordinating all program activities...  ...frequent reporting to company leadership Use disciplined project management methodology... 
    Senior
    Full time
    Work at office
    Worldwide
    Overseas
    Flexible hours

    Venturefizz Product Management Community

    Somerville, MA
    3 days ago

Do you want to receive more vacancies?

Subscribe and receive similar vacancies to Senior Program Manager, Program Leadership and Management. Be the first to apply!