Director, Medicinal Chemistry, Oligonucleotide Synthesis (San Diego)
$150k - $200kFull-time
Proven Recruiting
Director, Medicinal Chemistry, Oligonucleotide Synthesis expert, San Diego, CA , $150,000–$200,000 per year Are you ready to lead cutting-edge oligonucleotide discovery to the clinic? Our client, an innovative clinical-stage biotech company, is building transformative antisense medicines and seeking a strategic leader to drive their Medicinal Chemistry function. This is a high-impact, executive-level opportunity with strong influence on pipeline direction, platform innovation, and organizational growth. Who you are:
- Ph.D. in Medicinal Chemistry, Organic Chemistry, Pharmaceutical Sciences, or a related field
- 10+ years of industry experience in oligonucleotide therapeutics with leadership progression
- Proven success advancing antisense or RNA therapeutic candidates into clinical development
- Deep expertise in oligonucleotide chemistry, delivery/conjugation strategies, and CMC
- Strong leadership, strategic thinking, and cross-functional collaboration skills
- Lead medicinal chemistry efforts including oligonucleotide synthesis, SAR, and platform optimization
- Drive innovation in antisense chemistry and extrahepatic delivery strategies.
- Establish scalable synthetic processes and ensure regulatory readiness across programs
- Partner with Biology, Pharmacology, and DMPK teams to advance programs through IND and early clinical stages
- Build and lead a high-performing multidisciplinary team while contributing to overall company strategy
Vacancy posted 9 hours ago
Similar jobs that could be interesting for youBased on the Director, Medicinal Chemistry, Oligonucleotide Synthesis (San Diego) in San Diego, CA vacancy
- ...advancing transformative RNA medicines using best-in-class... ...in RNA biology, medicinal chemistry, and translational development... ...including but not limited to oligonucleotides synthesis, extrahepatic delivery... ...regulatory readiness. The Director, Medicinal Chemistry, will...SuggestedFull time
Arnatar Therapeutics
San Diego, CA9 hours ago - ...Director of Veterinary Medicine - San Diego CA An established small animal practice is seeking an Associate Veterinarian to join its supportive and collaborative medical team. This opportunity is ideal for a veterinarian who values high-quality patient care, strong...SuggestedRelocation package
Desort
San Diego, CA1 day ago $197.6k - $296.4k
Job DescriptionVertex is seeking a Director, Medicinal Chemistry to provide people management and strategic... ...objectives.Drive compound design, synthesis, and optimization to advance high-... ...at ****@*****.***: San Diego, CAType: Full timeSuggestedFull timeSummer workFlexible hoursVertex Pharmaceuticals
San Diego, CA2 days ago$197.6k - $296.4k
...Vertex Pharmaceuticals seeks a Director of Medicinal Chemistry in San Diego to lead small-molecule discovery programs and manage a chemistry team. The... ...aligned with portfolio objectives Lead compound design, synthesis, and optimization to create high-quality development...SuggestedVertex Pharmaceuticals
San Diego, CA9 days ago$175k - $260k
...Role Description We are seeking a highly motivated AD/Director, Chemistry to lead chemistry efforts supporting the discovery and advancement... ...The ideal candidate combines deep technical expertise in medicinal chemistry, bioconjugation, and ADC technologies with demonstrated...SuggestedFull timeRelocation packageFlexible hoursEnlaza Therapeutics
San Diego, CA9 hours ago$160k - $260k
...newly established, well-funded biotechnology company in San Diego is building a precision medicine pipeline in inflammatory bowel disease (IBD) — one... ...bench to clinic — this is a rare seat. The Role As Director, Biology, you'll serve as a project team lead,...Full timeIgnite Human Capital
San Diego, CAa month ago$170.6k - $255.8k
...ever thought possible.Position Title: Associate Director, Corporate StrategyFunction: Enterprise StrategyLocation: San Diego, California (Hybrid). This is a full-time... ...hypotheses, analyses, alternatives, and a clear synthesis; builds a trusted fact base; and turns...Full timeApprenticeshipWork at officeLocal areaRelocation packageMonday to Friday2 days per week3 days per weekIllumina
San Diego, CA2 days ago$170k - $195k
...venture-backed company based in San Diego, CA. We are an innovative... ...team developing DNA-based medicines that will be first-in-class... ...seeking an experienced Associate Director, Analytical Development to... ...: PhD in Analytical Chemistry or related discipline with 9...Full timeSeawolf Therapeutics, Inc.
San Diego, CA9 hours ago$184.4k - $276.65k
...receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.(Know Your Rights)SummaryLocation: Acton, Massachusetts; San Diego, CaliforniaType: Full timeFull timeWork at officeRemote workInsulet Corporation
San Diego, CA3 days ago$85k - $93.6k
...Director of Advancement Outside The Lens | San Diego, CA Full-time | $85,000–$93,600 annually Help build the relationships and resources that power youth creativity. Outside The Lens (OTL) is a San Diego-based nonprofit that creates opportunities for young...Full timePart timeLocal areaFlexible hoursOutside The Lens
San Diego, CA9 hours ago$154k - $256k
...Director, Biology Location: San Diego, CA (onsite) About the job SRT Therapeutics is seeking a Director, Biology to serve as a project team lead within Biology, supporting cross-functional drug development programs from discovery through IND-enabling studies...Full timeSRT Therapeutics Inc.
San Diego, CA9 hours ago$235k - $260k
...Work Authorization ~ United States (Required) Additional Compensation ~ Annual targeted bonus % Work Location: ~ San Diego office. Remote permitted upon approval, with ability to travel up to 25% for meetings or site visits as required. Equal...Full timeContract workWork at officeRemote workRelocation packageMonday to FridayProtego Bio
San Diego, CA9 hours ago- ...RETS Associates on behalf of our client, a privately held real estate investment and development firm, is seeking a Director of Acquisitions in San Diego to help lead the continued growth of its multifamily investment platform. The firm invests across value-add, core,...Full timeWork at office
RETS Associates
San Diego, CA9 hours ago - ...management and property maintenance services to communities throughout San Diego County. Since 1971, the organization has focused on delivering... ...standards and compliance. Role Description The Director of Community Management is a full-time, hybrid role based in San...Full timeFor contractorsWork at officeWork from home
N.N. Jaeschke, Inc.
San Diego, CA9 hours ago - ...Associate Medical Director – PACE San Diego, CA | Full-Time | On-Site | 70% Clinical / 30% Leadership Lead. Mentor. Make a Difference.... ...is an outstanding opportunity for an experienced Family Medicine or Internal Medicine physician leader who wants to remain...Full time
Curative
San Diego, CA9 hours ago - Reference: 629823Posted: 2026-09-22Location: San Diego, CaliforniaCompany: Planet Pharma GroupContact: ApplicationsEmail: ****@*****.*** Associate Director, Corporate Counsel, Legal Contracts is responsible for providing a high quality and diverse range...Contract workRemote work
Planet Pharma
San Diego, CA6 days ago $170.6k - $256k
## Director PCB CADSan Diego, California, United States of AmericaApply NowFind out how well you match with this jobJob ID: 3096779## **Company:**... ...Services Group > PWB Design**General Summary:**Location: onsite San Diego**Job Overview**Qualcomm is a company of inventors that...Work experience placementWork from homeOverseas$210k - $265k
...Protego Bio is a clinical-stage biotechnology company based in San Diego, California, focused on developing first-in-class small-... ...for transthyretin amyloidosis (ATTR). About the job The Director, Medical Writing is responsible for authoring, managing, and leading...Full timeWork at officeRemote workRelocation packageMonday to FridayProtego Bio
San Diego, CA9 hours ago$150k - $195k
Reference: 630393Posted: 2026-09-08Location: San Diego, CaliforniaCompany: Planet Pharma GroupContact: ApplicationsEmail: ****@*****.*** Summary:The Associate Director, Clinical Pharmacology will be responsible for the design, leadership, and implementation...Remote workShift workPlanet Pharma
San Diego, CA3 days ago- Director, Chemistry, Next Generation Genetic Medicine Ignite Human Capital is proud to represent a confidential client — a cutting-edge, early-stage genetic... ...optimization, and advancement of next-generation oligonucleotide therapeutics — with particular focus on...
- ...Job Description Job Description Associate Medical Director - PACE San Diego, CA | Full-Time | On-Site | 70% Clinical / 30% Leadership... ...is an outstanding opportunity for an experienced Family Medicine or Internal Medicine physician leader who wants to remain...Permanent employmentFull timeTemporary work
Curative
San Diego, CA29 days ago - ...project tracking, reporting, and collaboration tools such as Smartsheet, Jira, or similar platforms. Work Arrangement This is a 12-month contract position with a hybrid work arrangement in San Diego, CA, or Mountain View, CA. San Diego is strongly preferred....Contract workPart time
Catapult Solutions Group
San Diego, CA9 hours ago - ...aquatic species and the global food supply. Role Description The Human Resources Manager is a full-time, on-site role based in San Diego, CA, responsible for leading HR operations and supporting a growing, science-driven organization. Day-to-day tasks include...Full timeLocal area
The Center for Aquaculture Technologies (CAT)
San Diego, CA9 hours ago $73 per hour
...Technical Program Manager Contract: 12 months On-site in San Diego, CA. This is not a remote role. Rate: Up to $73 per hour (W2) I am not looking to work with any third-party agencies or vendors on this role. Seriously guys, please don't call me. Any unsolicited...Hourly payContract workPart timeSignify Technology
San Diego, CA9 hours ago$145k - $160k
...has been a champion for underrepresented communities throughout San Diego County, providing families in need with resources to achieve... ...information, please visit: LEADERSHIP & CULTURE The Director of Human Resources will report to Chief People Officer Dr. Taylor...Full timeContract workLocal areaFlexible hoursMAAC
San Diego, CA9 hours ago$85k - $100k
...that have significant impact on the trajectory of the greater San Diego region. To help make the San Diego region a better place to... ...has rapidly grown and gained momentum. The Associate Program Director will join OneSD at a crucial time, and in collaboration with the...Full timeBurnham Center for Community Advancement
San Diego, CA9 hours ago$170.6k - $255.8k
..., pay for consumption, and pay for performance. The Associate Director, Pricing will be responsible for creating robust pricing strategies... ...on-site presence as needed. The individual must reside in the San Diego area and be able to commute to our corporate offices.Essential...Full timeWork at officeLocal areaMonday to Friday2 days per week3 days per weekIllumina
San Diego, CA6 days ago$40 per hour
...exactly what you’ll do every time you come to work! As an Assistant Director of Human Resources, you’re not just supporting the Director in... ...passion for people and hospitality leadership to an iconic San Diego waterfront hotel! Hilton San Diego Bayfront is seeking an...Local areaWorldwideNight shiftHilton Hotels Corporation
San Diego, CA5 days ago- Reference: 630928Posted: 2026-09-15Location: San Diego, CaliforniaCompany: Planet Pharma... ...staffingfuture.comPosition Summary:The Associate Director, Labeling Strategy is responsible for... ...Biochemistry, Pharmaceutical Sciences, Chemistry, Chemical Engineering, or related field...Local areaRemote work
Planet Pharma
San Diego, CA5 days ago $141.6k - $212.4k
...an expectation of 3-4 in-office days per week and additional on-site presence as needed. The individual must reside in the greater San Diego area and be able to commute to our corporate offices.Responsibilities:Partner with senior leaders to understand business strategy,...Full timeWork at officeLocal areaMonday to FridayFlexible hours3 days per weekIllumina
San Diego, CA3 days ago
Do you want to receive more vacancies?
Subscribe and receive similar vacancies to Director, Medicinal Chemistry, Oligonucleotide Synthesis (San Diego). Be the first to apply!
Related searches
- director home care San Diego, CA
- director of fulfillment San Diego, CA
- academic director San Diego, CA
- director of materials management San Diego, CA
- senior director San Diego, CA
- director of missions San Diego, CA
- senior director coding San Diego, CA
- erp director San Diego, CA
- director of demand generation San Diego, CA
- director of architecture San Diego, CA