Senior Research Scientist

**Inflammation Research - In Vivo Pharmacology Senior Scientist**At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.**Inflammation Research - In Vivo Pharmacology Senior Scientist****What you will do**The Department of Inflammation Research is seeking a dedicated, driven and independent Senior Scientist to join the In Vivo Pharmacology (IVP) group as part of a fast-paced, integrated and interactive research group exploring therapeutics for Inflammation, Autoimmune, and Rare Disease programs. The successful candidate will be responsible for designing and executing experiments exploring and understanding the pharmacology of drug targets; generating, communicating pharmacology and preclinical data to support the progression of research projects, and providing technical expertise to therapeutic area scientists. This role has the potential for managing up to one report initially, contribution to project teams, collaboration with therapeutic area scientists and teams at multiple Amgen sites.**Who are you*** PhD degree in immunology, biology, pharmacology or relative disciplines with strong knowledge of *in vivo* Pharmacology and experience working with PK-PD relationships.* Post-doc or industry experience will be a plus.* Strong expertise in hands-on expertise in animal (rodent) handling and *in vivo* techniques (i.v., i.p., p.o., i.d., s.c., i.t., bleeds, necropsy) essential.* Significant experience designing and executing concurrent *in vivo* preclinical inflammation and autoimmune disease models. Experience with colitis, lupus, arthritis, hepatitis, and immune modulation (TLR, DTH, Immunization) models preferred. Experience in derm, rheumatoid, and respiratory disease models is preferred.* Hands-on experience with ex vivo / in vitro cellular, and biochemical assay techniques (i.e. ELISA, MSD, WB, quantitative RT-PCR, tissue protein extraction) is essential.* Significant experience with multicolor flow cytometry, including Spectral flow approaches and knowledge of and experience working with immune cell populations is essential.* Experience working in a collaborative team-oriented environment and working on project teams leading in vivo contributions is essential.* Attention to detail, excellent organizational, time management, and communication skills, accurate & timely record keeping and data analysis are essential.* Demonstrated track record of independent critical thinking and scientific achievement.* Computer literacy, especially proficiency with GraphPad Prism, Excel, PowerPoint and Word.**Key Responsibilities**:* Design, conduct and lead *in vivo* preclinical model studies and ex vivo analysis independently in collaboration with Inflammation scientists and collaborators.* Design, execute and data analysis of cutting-edge research and in vivo pharmacology experiments contributing to Amgen’s Inflammation TA research pipeline.* Manage a scientist/associate scientist level direct report* Utilize *in vivo* pharmacology and animal models to validate and accelerate molecules through the research pipeline.* Inform, collaborate, and communicate *in vivo* planning and results with therapeutic area (TA) scientists to align with project goals.* Responsibility for and oversight of study data quality and analysis from group.* Represent the pharmacology team on pipeline project teams. Present results at internal meetings and external conferences.**Basic Qualifications:*** Doctorate degree* OR* Master’s degree in immunology or cell biology, or related discipline and 2 years of industry experience in biotech/pharma* OR* Bachelor’s degree in immunology or cell biology, or related discipline and 4 years of experience in biotech/pharma**Preferred Qualifications:*** Experience managing an in vivo pharmacology team or direct reports.* Demonstrated track record of independent critical thinking and scientific achievement as exemplified by your publication record and / or significant contribution to a therapeutic program* Proactive, curious, and eager to learn and contribute to cutting edge science and serve patients in a highly productive team environment.**What you can expect of us**As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:* A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts* A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan* Stock-based long-term incentives* Award-winning time-off plans* Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.## Apply now and make a lasting impact with the Amgen team.**careers.amgen.com**In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.## Application deadline## **External/Internal postings:**Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.## **Internal only posting (or Pre-ID candidate):**Amgen anticipates accepting applications however, we may continue accepting applications beyond this date if we do not receive a sufficient number of candidates.## SponsorshipSponsorship for this role is not guaranteed.As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.## Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.**Salary Range**123,052.80USD -166,483.20 USD #J-18808-Ljbffr