Research / Sr. Research Investigator, Quantitative Pharmacology

A global biopharmaceutical company on a mission to Solve On, Incyte follows science to find solutions for patients with unmet medical needs. Through the discovery, development, and commercialization of proprietary therapeutics, Incyte has established a portfolio of first-in-class medicines for patients and a strong pipeline of products in Hematology, Oncology and Inflammation and Autoimmunity. Headquartered in Wilmington, Delaware, Incyte has operations in North America, Europe, and Asia.

We are seeking a pharmacometrician to join our Clinical and Quantitative Pharmacology organization in Translational Medicine. A Research Investigator or Senior Research Investigator supports the execution of model-based analyses for clinical drug development and is expected to contribute to key programs under mentorship and guidance. This role will be responsible for applying model-informed drug development (MIDD) approaches to support decision-making across phases of drug development. Candidates will be evaluated on a case-by-case basis as to whether their experience aligns with the Research Investigator or Senior Research Investigator requirements.

Essential Functions of the Job (Key responsibilities)

• Conducts model-based analyses including population pharmacokinetics (PK) and pharmacokinetics/pharmacodynamics (PK/PD), and exposure-response modeling under the guidance of senior team members.
• Assists in identifying opportunities where modeling and simulation can advance the understanding of pharmacokinetics, pharmacodynamics, efficacy, and safety within assigned projects.
• Supports the development of MIDD strategies to optimize prospective studies and inform clinical development in collaboration with partners (clinical pharmacology, biostatistics, regulatory, and clinical development teams).
• Communicates results, conclusions, and assumptions of pharmacometrics analyses to internal audiences in written reports and oral presentations.
• Stays current with scientific advancements and regulatory trends in clinical pharmacology and pharmacometrics, and applies this knowledge to support drug development goals.
• Contributes to peer-reviewed publications and internal scientific communications.

Qualifications (Minimal acceptable level of education, work experience, and competency)

• Advanced degree in Pharmacometrics, Clinical Pharmacology, Applied Mathematics, Statistics, Engineering, or a related field.
• 0 to 2 years of related post-doctoral experience in pharmacometrics or clinical pharmacology (industry or academic).
• Hands-on experience with NONMEM and R for pharmacometrics analyses.
• Excellent communication skills and ability to collaborate with cross-functional teams.
• Strong time management skills and ability to balance execution of multiple tasks to accomplish program goals.

Disclaimer: The above statements are intended to describe the general nature and level of work performed by employees assigned to this job. They are not intended to be an exhaustive list of all duties, responsibilities, and qualifications. Management reserves the right to change or modify such duties as required.

Incyte Corporation is committed to creating a diverse environment and is proud to be an equal opportunity employer.

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