Lead Research Associate - Cell Biology & Assays

At Caris, we understand that cancer is an ugly word—a word no one wants to hear, but one that connects us all. That’s why we’re not just transforming cancer care—we’re changing lives. We introduced precision medicine to the world and built an industry around the idea that every patient deserves answers as unique as their DNA. Backed by cutting‑edge molecular science and AI, we ask ourselves every day: “What would I do if this patient were my mom?” That question drives everything we do. But our mission doesn’t stop with cancer. We're pushing the frontiers of medicine and leading a revolution in healthcare—driven by innovation, compassion, and purpose. Join us in our mission to improve the human condition across multiple diseases. If you're passionate about meaningful work and want to be part of something bigger than yourself, Caris is where your impact begins. Position Summary Research Associate IIIs serve as technical leaders within the laboratory, driving complex experimental workflows and ensuring scientific excellence across multiple platforms. This position requires expertise in mammalian cell culture systems and cell‑based assays for validation of drug targets. This RA III position will independently design, execute, and optimize experiments involving cell growth and cytotoxicity assays, immunocytochemistry (ICC), cellular internalization, antibody characterization & validation, and other cellular and molecular biology techniques. Additional responsibilities may include preparation of formalin‑fixed paraffin‑embedded (FFPE) blocks, PCR, protein extraction and quantification, western blotting, biomarker discovery/target identification, affinity purification, immunoprecipitation, ELISA/ELONA, RNA/DNA extraction and QC, Next‑Generation Sequencing sample preparation, mass spectrometry sample preparation, and aptamer selection. Research Associate IIIs play a key role in laboratory operations, including equipment oversight, inventory management, sample tracking, and onboarding/training of new team members. They collaborate closely with research scientists, senior scientists, and R&D leadership, contributing to experimental planning, troubleshooting, and continuous improvement of laboratory workflows. Job Responsibilities Demonstrates advanced proficiency in mammalian cell culture, immunocytochemistry, cellular internalization assays, and cytotoxicity assays, and other technologies listed in the Position Summary. Independently designs, executes, and interprets complex experiments, providing scientific insight and recommending next steps. Serves as a technical mentor to fellow Research Associates, Molecular Technologists, and new team members; leads hands‑on training in advanced techniques and best practices. Develops and optimizes SOPs, workflows, and QC procedures to improve data quality, reproducibility, and operational efficiency. Performs routine and advanced maintenance of laboratory equipment; ensures compliance with calibration, documentation, and safety standards. Manages reagent and consumable inventory, including verification, documentation, labeling, and storage under appropriate conditions. Collaborates cross‑functionally with R&D, Operations, Quality and Safety teams to support project goals and troubleshoot technical challenges. Contributes to experimental planning, project timelines, and data review discussions with senior scientific staff. Performs additional duties as assigned to support laboratory and organizational objectives. Required Qualifications Bachelor’s degree with four years post‑graduate experience or Master’s degree with two years post‑graduate experience in a relevant scientific field. Extensive hands‑on experience in mammalian cell culture, sterile technique, and cell‑based assays including plate design, instrument setup, and data analysis. Demonstrated ability to troubleshoot complex technical issues and interpret multidimensional datasets. Proven success working in a fast‑paced, deadline‑driven research environment. Excellent written and verbal communication skills, including the ability to present data and train others effectively. Deep understanding of laboratory safety procedures, biohazard handling, chemical safety, and regulatory compliance. Exceptional attention to detail, organizational skills, and documentation accuracy. Ability to clearly articulate prior experience with molecular and cellular assays, including controls, data interpretation, and troubleshooting strategies. Proficiency with Microsoft Office Suite and standard laboratory data systems. Preferred Qualifications Master’s degree in biological science field. Experience leading small project teams or acting as a technical lead. Experiences in cell culture, cell growth and viability assays, immunocytochemistry (ICC), microscopic imaging, cellular internalization and cytotoxicity assays will be a plus. Strong commitment to quality, continuous improvement, and operational excellence. Demonstrated ability to work collaboratively across teams and contribute to shared scientific goals. Physical Demands Periodic computer work and use of office equipment for documentation and inventory management. Visual acuity to distinguish fine detail; ability to pass a color‑vision test. Manual dexterity for sterile technique and operation of laboratory instruments. Ability to sit or stand for extended periods and perform repetitive motions. Ability to lift up to 30 pounds. Potential exposure to noise, fumes, chemicals (including carcinogens), and biohazardous materials. May handle blood‑borne pathogens and general laboratory reagents. Possible exposure to extreme temperatures and chemical fumes. Training All job‑specific, safety, and compliance training assigned based on responsibilities and regulatory requirements. Other Periodic travel and occasional evening, weekend, or holiday work may be required. May require after‑hours response to urgent laboratory or equipment issues. Participation in on‑call rotations as needed. Conditions of Employment Individual must successfully complete pre‑employment process, which includes criminal background check, drug screening, credit check ( applicable for certain positions) and reference verification. This job description reflects management’s assignment of essential functions. Nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time. Caris Life Sciences is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, gender, gender identity, sexual orientation, age, status as a protected veteran, among other things, or status as a qualified individual with disability. #J-18808-Ljbffr Caris Life Sciences