Associate Scientist/Scientist (LNP Process Development)

Associate Scientist/Scientist (LNP Process Development) Responsibilities: Independently plan, conduct, analyze, and troubleshoot laboratory studies, using sound scientific judgment to drive projects forward. Develop and optimize LNP and targeted LNP formulation and synthesis methods for preclinical research, including both small-scale batches and process scale-up. Evaluate LNP quality attributes including mRNA encapsulation and integrity, particle size and PDI, zeta potential, ligand attachment, free ligand, lipid content, pH, osmolality, and related parameters. Prepare, characterize, and monitor LNP and targeted LNP materials to support internal research programs and cross-functional studies. Contribute to the development and qualification of analytical methods used to establish critical quality attributes for drug substances and drug products. Partner with internal scientists and external collaborators to support in vitro and in vivo LNP studies, ensuring materials are delivered on schedule and accompanied by appropriate characterization data. Communicate experimental results and scientific conclusions through technical presentations to cross-functional teams and senior leadership. Support technology, process, and analytical method transfers to external CDMOs and CROs. Prepare, review, and maintain ROPs, technical documentation, and reports supporting regulatory submissions. Identify experimental or process challenges and work collaboratively to develop practical solutions. Provide technical support, guidance, and mentorship to less experienced scientists. Maintain accurate experimental records, results, and supporting documentation in an electronic laboratory notebook. Requirements: BS, MS, or PhD in Bioengineering, Chemical Engineering, Chemistry, Materials Science, Biochemistry, Biology, or a related scientific discipline, with 3+ years of relevant industry laboratory experience. Demonstrated hands-on experience in LNP, liposome, polymeric nanoparticle, or related formulation and/or process development. Practical experience with nanoparticle characterization and analytical techniques such as RiboGreen, DLS, PALS, SEC, IP-RP LC, LC-CAD, Flow NanoAnalyzer, BCA/microBCA, pH, osmolality/freezing point depression, LAL, sterility, and related methods. Experience manufacturing lipid nanoparticles and supporting process scale-up is highly preferred, including familiarity with microfluidic mixing, tangential flow filtration (TFF), or comparable technologies. Strong experimental design, data analysis, troubleshooting, organization, and project-planning skills. #J-18808-Ljbffr Commonwealth Sciences, Inc.