Principal Scientist, Medicinal Chemistry

Description

Company Overview: Vividion is a next generation biotechnology company based in San Diego that is leveraging its proprietary chemical proteomics platform to conduct proteome-wide footprinting of drug-protein interactions with unprecedented breadth and precision. Our technology allows us to screen, identify and optimize novel drugs that selectively bind virtually any protein, including proteins previously considered “undruggable”. Our pipeline and emerging programs reflect a matured and productive platform capable of delivering first in class drugs utilizing novel mechanisms of action (allosteric inhibitors, protein-protein interaction inhibitors, functional activators, degraders etc.) against undruggable targets in the oncology and immunology space.

We prize scientific excellence, creativity, team players and we are committed to continued innovation. We have worked hard to create a collaborative and dynamic work culture where your ideas and discoveries are valued and will have an impact. We are growing and there are opportunities for mentorship and career progression.

Vividion has been recognized as a Top Workplace by The San Diego Union-Tribune from 2022 to 2025.

Job Summary

As a senior member of the Vividion chemistry department, the successful candidate will be able to contribute to all priority phases of the drug discovery process including library growth, hit identification, hit to lead, and guide lead optimization programs to successful Development Candidate nominations and IND submissions. The preferred candidate will be comfortable balancing traditional approaches, exploring novelty on the cutting edge of modern small-molecule drug discovery, and have a thirst to constantly learn.

Requirements

Education and Experience requirements:

• PhD in synthetic organic chemistry with 8+ years of industry experience in small molecule drug discovery with a clear understanding of program strategy, therapeutic hypothesis, assay relevance and clinical translation, and the importance of physical-chemical properties as it relates to enabling late-stage in vivo studies and clinical dosing.
• A clear command of classical and modern synthetic methodology and reaction mechanism.
• Expertise to craft compounds that fully exploit insights from ligand and/or structure-based design while fully exploiting all available synthetic methods.
• Proven leadership skills within and across multiple functions as part of integrated drug discovery teams as exemplified by delivery of development candidate small molecules.
• Experience in mentoring and managing both internal junior chemists and outsource chemistry resources.
• Excitement and unhesitating commitment to advance a rapidly growing biotech organization in any way necessary including from the lab as needed.

Required Key Attributes

• Curiosity
• Fearlessness
• Creativity
• Attention to detail
• Willingness to challenge dogma

Pay & Benefits

The anticipated base salary for this position ranges from $165,000 to $180,000 depending on relevant skills, competencies, experience, and education. In addition, this position is eligible for target bonus, long-term-incentives, 401k retirement savings plan with company match, and a comprehensive benefits package which includes medical, dental, vision, life, and disability insurance.

EEO & Employment Eligibility

Vividion Therapeutics, Inc. is an equal opportunity employer. All applicants will receive consideration for employment without regard to disability or veteran status.

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