Computational Protein Engineer
Gables Search Group
We are recruiting for a research-driven biotechnology organization seeking a Computational Protein Engineer to lead hands-on antibody and protein engineering programs in Rockville, Maryland. This position combines wet-lab experimentation with computational design tools to accelerate discovery, guide design decisions, and improve experimental outcomes.
The organization offers scientists meaningful independence, access to accomplished colleagues, and the opportunity to pursue creative research with long-term impact.
Key Responsibilities
Lead antibody and protein engineering programs, including affinity maturation, multispecific antibodies, and novel binder development
Develop protein expression, purification, and analytical characterization workflows across multiple formats
Design binding, biochemical, and functional assays to evaluate engineered candidates
Apply tools such as AlphaFold, Rosetta, and ProteinMPNN to prioritize designs and guide laboratory strategies
Partner with structural biologists and computational scientists to translate modeling insights into experimental programs
Provide technical leadership across complex, multidisciplinary research initiatives
Communicate findings, recommendations, and project progress to scientific stakeholders
Qualifications
PhD in biochemistry, molecular biology, protein science, or a related discipline
Industry experience conducting hands-on antibody or protein engineering research
Strong expertise in protein expression, purification, characterization, and assay development
Experience with bispecific antibodies, nanobodies, multispecific proteins, or similar modalities
Familiarity with computational protein design and structure-prediction platforms
Scientific contributions demonstrated through publications, patents, or successful development programs
Ability to lead technical projects and collaborate across scientific disciplines
Apply today to explore a position where computational design and experimental protein engineering come together to advance meaningful scientific discovery.
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