Senior Director, Pharmacokinetics, Dynamics, Metabolism and Bioanalysis, Protein Therapeutics (Boston)

Overview

Pharmacokinetics, Dynamics, Metabolism and Bioanalytics (PDMB) group is seeking a Senior Director to contribute to our company’s protein therapeutic efforts from discovery through to candidate selection and into first‑in‑human trials.

Position based at research labs in Boston, MA.

Responsibilities

• Oversee the design and interpretation of pharmacokinetic, immunogenicity, and ADME studies for protein therapeutics across multiple disease indications and therapeutic areas.
• Mentor and manage a team of high‑performing PDMB scientists and managers (multi‑tiered organization) supporting protein therapeutic optimization (PK, distribution, translational strategy) and discovery bioanalytics (ligand binding assays, mass spectrometry).
• Design, implement, and analyze in‑vitro and in‑vivo studies to understand the impact of drug disposition on disease biology, pharmacological response (PK/PD), and safety.
• Contribute to global PDMB strategy through close collaboration with project teams in Boston (MA), South San Francisco (CA), and West Point (PA) focusing on building highly efficient strategies to identify and optimize protein therapeutic drug candidates.

Education and Experience

• Ph.D. with 7+ years relevant experience. Degree in biochemistry, pharmacology, pharmaceutical sciences, protein engineering, molecular biology, bioengineering, or related STEM field.
• Proven record of increasing responsibility and independence in an industrial or academic setting.
• Demonstrated experience leading protein therapeutic discovery efforts as a group leader or independent project‑team representative within a highly collaborative environment.
• Strong understanding of protein therapeutic bioanalytical, ADME, FcRn biology, target‑mediated drug disposition (TMDD), and immunogenicity concepts for modalities such as monoclonal antibodies or engineered bispecifics.
• Track record of managing scientists and leading cross‑functional teams in a drug discovery or development setting.
• Experience contributing to development and execution of translational PK/PD efficacy relationships, human dose predictions and other quantitative pharmacology applications in a discovery setting.

Preferred Experience and Skills

• Hands‑on experience performing or interpreting data from translational PK/PD/efficacy or physiologically‑based pharmacokinetic (PBPK) models (e.g., Phoenix WinNonlin, Berkeley Madonna, MATLAB).
• Supporting immunology or oncology‑based programs with experience spanning from early discovery through IND‑enabling effort.
• Expertise in designing and troubleshooting ligand binding assays or hybrid‑LC/MS assays for the detection and quantitation of protein therapeutics in various matrices (non‑GLP).
• Experience working within a research‑driven pharmaceutical company.

Required Skills

• ADME, Assay Development, Bioanalysis, Bioanalytical Assays, Bispecific Antibodies, Communication, Cross‑Cultural Awareness, Drug Discovery Development, Drug Metabolism, Fast‑Paced Environments, Immunology, Immunotherapy, Innovation, Ligand Binding Assay, Modeling Simulations, Monoclonal Antibodies, Oncology, People Leadership, Pharmacokinetics, PKPD Modeling, Protein Engineering, Results‑Oriented, Scientific Leadership, Strategic Thinking, Therapeutic Proteins.

Salary and Benefits

Salary range: $194,100.00 – $305,600.00, based on education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs. Eligible for annual bonus and long‑term incentive, if applicable.

Benefits include medical, dental, vision, healthcare insurance for employee and family, retirement benefits including 401(k), paid holidays, vacation, compassionate and sick days.

Equal Opportunity Statement

Our company is an equal opportunity employer. We provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. We comply with all affirmative action requirements for protected veterans and individuals with disabilities.