Senior Scientist
Deciphr Health
About Us Deciphr Health is a seed-stage biotech developing programmable DNA nanostructures for next-generation point-of-care diagnostics. Our first clinical application targets preeclampsia screening — a condition that affects 1 in 25 pregnancies with no adequate rapid test. We're building from our R&D lab in San Carlos, CA.
The Role You'll own the aptamer discovery pipeline end-to-end: from SELEX campaign design through NGS-based candidate selection to biochemical characterization of lead binders. This is a hands-on bench role with high autonomy — you'll be the team's go-to expert on nucleic acid selection, modification, and bioconjugation. You'll also contribute to our broader DNA nanostructure platform (with internal training provided).
What You'll Do
- Design and run SELEX campaigns (affinity-based and capture-release formats) against clinically relevant protein targets
- Perform site-specific bioconjugation of oligonucleotides to proteins, fluorophores, and surface chemistries
- Purify and QC modified oligos and conjugates (HPLC, FPLC, spin-column)
- Prepare and manage NGS libraries to identify top aptamer candidates from selection rounds
- Monitor selections via qPCR/RT-PCR and develop binding validation assays
- Support fabrication and testing of DNA nanodevices following internal protocols
What We're Looking For
- PhD in Biochemistry, Molecular Biology, Chemistry, or related field — or MS with 3–5+ years of hands-on industry experience
- Deep, demonstrated expertise in SELEX (not just familiarity — you've run campaigns)
- Strong oligo handling skills: purification, chemical modification, conjugation chemistry
- Proficiency with HPLC, qPCR, and NGS library prep workflows
- Comfort working in a startup environment with minimal infrastructure and high ownership
Nice to Have
- Exposure to DNA nanotechnology or structural DNA assembly
- Experience with phage display, cell-SELEX, or tissue-based selections
- HPLC instrument maintenance and troubleshooting
Compensation Base salary commensurate with experience + meaningful early-stage equity.
Location San Carlos, CA (on-site; this is a lab-based role).
Vacancy posted 1 day ago
Similar jobs that could be interesting for youBased on the Senior Scientist in San Francisco, CA vacancy
- Celltheon Corporation in San Francisco is seeking a Scientist / Senior Scientist specialized in Cell Culture, Functional Assay Development, and Automation. This role involves developing and optimizing functional assays, authoring methods for liquid handlers, and collaborating...Senior
- ...build the next infrastructure for vision and intelligence in the physical world. About the Role We are seeking a Senior Geospatial Scientist to lead the development of algorithms and data pipelines that transform our ultraspectral imagery into actionable intelligence...SeniorPermanent employmentTemporary workRemote work
Matter Intelligence
San Francisco, CA4 days ago - A pioneering biotechnology firm in San Francisco is seeking a Senior Scientist to lead the organ preservation team. You will play a crucial role in advancing organ transplant research, utilizing your expertise in organ viability evaluation and cryopreservation. Ideal candidates...SeniorFlexible hours
- Freenome is seeking a Senior Research Associate in Brisbane, California, to grow their Genomics Assay Development team. The role involves developing assay technologies for early cancer detection using next-generation sequencing. Ideal candidates will have a Bachelor's...Senior
$257.4k - $330k
...Senior / Principal Machine Learning Scientist San Francisco Bay Area, CA; San Diego, CA Our Mission Our mission is to restore cell health and resilience through cell rejuvenation to reverse disease, injury, and the disabilities that can occur throughout life....SeniorContract workWork experience placementLocal areaAltos Labs
San Francisco, CA1 day ago$268k - $384k
...Senior / Principal ML Scientist, Foundation Models for Life Sciences San Francisco, CA USA Your Impact at LILA Lila is building a platform where AI and automation co-evolve to solve the hardest problems in medicine. Within Life Science AI (LSAI), the Foundation...SeniorFull timeWork at officeLocal areaFlexible hoursLila Sciences
San Francisco, CA1 day ago$120k - $160k
...with cross-functional colleagues in chemistry, pharmacology, biology, DMPK, and project teams. The ideal candidate is a rigorous scientist with strong molecular design & communication skills, sound scientific judgment, and a collaborative approach to advancing programs...SeniorLocal area$145k - $180k
...no terminal diagnosis is final because patients can safely wait for future medicine to arrive. About The Role We are seeking a Senior Scientist to join as a leader on our whole organ preservation team. You will have large domain of ownership and play a vital role in...SeniorFlexible hours$180k - $250k
A leading ML hardware company in San Francisco is seeking a Senior Research Engineer to pioneer developments in probabilistic machine learning models. Candidates should have a strong background in scientific Python, deep learning frameworks, and foundational mathematics...Senior- ...within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. Senior Scientist - Computational Discovery & Translational Analytics What you will do Let’s do this. Let’s change the world. We are seeking a...SeniorFlexible hours
$200k - $275k
...Job Description: Senior Machine Learning Scientist sf, ca Senior Machine Learning Scientist, you will play a leading role in designing the next generation of foundation models of gene regulatory networks powered by Tahoe's large scale single-cell datasets...SeniorWork at officeVisa sponsorshipFree visa3 days per weekESR Healthcare
San Francisco, CA4 days ago$110k - $155k
...breakthrough therapies faster. Join this digital transformation and help scientists around the world accelerate the pace of biopharma R&D. Learn... ...which makes everything possible. The Position: As a Senior Mass Spectrometry Scientist, you will work with leading...SeniorFull timeWork at officeWorldwideDanaher Corporation
San Francisco, CA4 days ago$200.9k - $257.5k
...Machine Learning Scientist / Senior Machine Learning Scientist, Virtual Cell San Francisco Bay Area, CA; San Diego, CA Our Mission Our mission is to restore cell health and resilience through cell rejuvenation to reverse disease, injury, and the disabilities...SeniorContract workWork experience placementLocal areaAltos Labs
San Francisco, CA1 day ago- A prominent biotechnology firm is seeking a skilled individual to join their team focused on CAR-T therapies. This role includes developing analytical methods, managing flow cytometry data, and collaborating with R&D groups to support clinical manufacturing processes. The...Senior
- EliseAI is looking for a Senior Research Scientist in San Francisco to advance machine learning research. The ideal candidate will have a Ph.D., five years of relevant experience, and a strong grasp of algorithm development and statistical modeling. Responsibilities include...Senior
$112.95k - $131.78k
Cytokinetics in South San Francisco seeks a Senior Research Associate to support preclinical cardiac research programs. Responsibilities include conducting experiments to evaluate compounds for treating cardiac diseases, maintaining iPSC banks, and collaborating with multidisciplinary...Senior$135k - $190k
A biopharma company in San Francisco seeks a Senior Scientist for their Discovery Biology Team. This role involves developing novel cellular assays, leveraging expertise in cancer biology to drive cutting-edge therapy research. The ideal candidate will have a PhD or equivalent...Senior$125k - $155k
A leading biotechnology company in South San Francisco is looking for a full-time laboratory Scientist/Senior Scientist for the Histology team. This role involves performing IHC, IF, and ISH experiments to validate novel targets and therapeutics. The ideal candidate holds...SeniorFull time$192.2k - $260k
...organization, including sales operations and business performance optimization. The ACES Sales Channels team is hiring an Applied Scientist (Senior or below) to advance our mission of providing rigorous, causal-inference-driven recommendations for AWS sales optimization....SeniorWork at officeLocal areaFlexible hoursAmazon
San Francisco, CA12 hours ago- Amgen SA is seeking a Senior Scientist in Computational Systems & Predictive Biology in San Francisco, California. The role involves developing and implementing computational systems for biological data analysis and target validation. Ideal candidates will have a PhD in...Senior
$173.78k - $246.75k
...About this opportunity: At Freenome, we are seeking a Senior Machine Learning Scientist to help grow the Machine Learning Science team, within the Computational Science department. The ideal candidate has a strong knowledge of artificial intelligence (AI), including...SeniorHourly payWork at officeLocal areaRemote work2 days per week3 days per weekFreenome
Brisbane, CA12 hours ago$215k - $235k
...insitro, we use machine learning to derive clinically relevant insights from rich datasets generated in-house. As an Imaging ML Scientist, you will develop ML-empowered computer vision pipelines to extract insights about disease mechanisms from multiple microscopy...SeniorHome officeFlexible hours3 days per weekinsitro
San Francisco, CA1 day ago$120k - $160k
Tenvie Therapeutics, located in Brisbane, California, is seeking a motivated medicinal chemist for the Small Molecule Discovery team. The successful candidate will design and execute experiments to advance innovative small molecule therapeutics. Responsibilities include...Senior- A leading transcription service provider in San Francisco is looking for a highly skilled Computer Scientist to enhance the performance of Large Language Models (LLMs), focusing on Retrieval Augmented Generation (RAG) models and optimization techniques. The position demands...Senior
$147.5k
Responsibilities Determine optimal product pricing and margin targets through complex economic analysis and modeling while identifying and controlling for correlations, errors, covariances, and other statistically significant economic indicators affecting pricing. ...SeniorLocal areaRemote workHome officeChipper Cash
San Francisco, CA4 days ago- Biogen, Inc. is looking for a Principal Scientist in Clinical Biomarkers based in San Francisco. In this hybrid role, you will design and implement biomarker strategies across clinical studies, collaborating closely with various teams to deliver high-quality data. The ideal...Senior
$190k - $211k
A leading transport technology company based in San Francisco is seeking a Data Scientist to join their Mobility Matching Science team. You will develop data-driven insights and collaborate with various stakeholders. The ideal candidate will have a Ph.D. in a quantitative...Senior- MixMode is seeking a highly skilled molecular dynamics expert to lead and contribute to projects involving enhanced sampling and free energy calculations. The ideal candidate holds a PhD in a relevant field and has strong experience with force-field/neural network potential...Senior
$145k - $160k
..., most selective targets for a variety of immunotherapeutic approaches. Cartography Biosciences is seeking a highly motivated Senior Scientist to join our Pharmacology team and play a pivotal role in in vitro development and characterization of novel T cell engagers across...Senior- ...and contribute to technical reports for regulatory filings and responses as appropriate. Regularly present data and strategies to scientists and management in internal and external venues, and publish in peer-reviewed journals as appropriate. Technical Skills Extensive...Senior
Do you want to receive more vacancies?
Subscribe and receive similar vacancies to Senior Scientist. Be the first to apply!
Related searches
- downstream processing scientist San Francisco, CA
- machine learning research scientist San Francisco, CA
- drug safety scientist San Francisco, CA
- remote scientist San Francisco, CA
- graduate scientist San Francisco, CA
- operations research scientist San Francisco, CA
- senior scientist San Francisco, CA
- research associate scientist San Francisco, CA
- scientist assay development San Francisco, CA
- r&d scientist San Francisco, CA