Scientist, Reagent Development

Sarmal, Inc. is a San Diego–based biotechnology company developing next-generation genomics and molecular detection platforms. Our work integrates molecular biology, chemistry, and advanced systems engineering to enable faster, more precise, and more accessible genomic insights. We are a highly collaborative, R&D-driven team operating in a fast-paced, early-stage environment. Our scientists and engineers work across disciplines to solve complex technical challenges and translate innovation into scalable, real-world applications. At Sarmal, we value scientific rigor, curiosity, and a builder mindset. We are looking for individuals who are energized by ambiguity, motivated by impact, and excited to help bring breakthrough technologies from concept to reality. About the Job The Reagent Development Scientist will lead formulation and optimization of diagnostic assay reagents used across Sarmal's molecular diagnostics assay workflows. This role requires extensive experience in reagent chemistry, assay optimization, stability studies, accelerated aging, shelf-life determination, and lyophilized reagent development. The successful candidate will work closely with assay development, quality, and engineering teams to translate research reagents into robust commercial products. Key Role and Responsibilities Design and optimize reagent formulations for molecular diagnostic assays. Develop stable reagent systems for PCR, isothermal amplification, and enzymatic reactions. Design and execute accelerated and real-time stability studies. Establish reagent shelf life using statistical analysis of stability data. Develop and optimize lyophilization cycles and reagent formulations for freeze-dried products. Evaluate stabilizers, excipients, cryoprotectants, and buffer systems to maximize reagent performance. Characterize reagent performance under varying environmental conditions including temperature, humidity, and shipping stress. Perform formulation optimization for enzymes, primers, probes, nucleotides, and other assay components. Design DOE (Design of Experiments) studies to optimize reagent composition and manufacturing robustness. Troubleshoot reagent performance issues observed during manufacturing or customer use. Maintain detailed experimental documentation and contribute to technical reports. Qualifications Extensive experience developing reagents for molecular diagnostics or IVD products. Hands‑on expertise in reagent formulation chemistry. Demonstrated experience designing and executing stability studies. Experience with accelerated aging protocols and shelf‑life modeling. Expertise in lyophilization process development and optimization. Knowledge of formulation strategies for enzymes and biological reagents. Experience evaluating reagent stability under thermal, shipping, and environmental stress. Strong understanding of assay performance metrics including sensitivity, specificity, precision, and robustness. Familiarity with Design of Experiments (DOE) methodologies. Experience transferring formulations into manufacturing. Knowledge of ISO 13485 and IVD development practices is highly desirable. Excellent experimental design, troubleshooting, and data analysis skills. Ability to thrive in a fast‑paced startup environment. Experience Ph.D. or M.S. in Biochemistry, Chemistry, Molecular Biology, Biomedical Engineering, Chemical Engineering, or related discipline. Ph.D. with 3–5+ years or M.S. with 7+ years of relevant industry experience. Demonstrated experience developing commercial diagnostic assay reagents. Proven experience conducting reagent stability and shelf‑life studies. Experience supporting transfer of reagent formulations into manufacturing. Experience with molecular diagnostics, PCR, qPCR, sequencing technologies is strongly preferred. Experience with FDA-regulated IVD products is a strong plus. Why Join Sarmal Work on cutting‑edge genomics and molecular detection technologies Collaborate with a deeply technical, cross‑functional team Contribute to foundational platform development at an early stage Have visibility into and impact on core technical and strategic decisions Help shape the infrastructure, culture, and future direction of the company Salary Range The anticipated salary range for this position is $80K–$135K depending on experience and qualifications. Final compensation will be determined based on a variety of factors including, but not limited to, location, relevant experience, skill set, and internal equity considerations. Benefits Medical (100% employee) coverage Dental and vision coverage Company‑paid life insurance Generous paid time off Holiday recharge period in addition to observed holiday schedule Access to additional voluntary benefits, employee perks, and discount programs Access to onsite gym We are committed to supporting the well‑being of our employees and providing a strong foundation for both professional and personal success. Additional Information Applicants must have legal authorization to work in the United States without the need for current or future employer sponsorship. All new hires will be required to verify identity and eligibility to work in the United States, and complete Form I‑9 upon hire. We do not accept unsolicited resumes from search firms. Any resume submitted without a signed agreement will be considered unsolicited, and Sarmal will not be obligated to pay any fees. Sarmal is an equal opportunity employer committed to building a diverse and inclusive team. We do not discriminate based on any protected characteristic under applicable federal, state, or local law. If you require reasonable accommodation during the application or interview process, please contact the Human Resources team at View email address on click.appcast.io. We are committed to ensuring equal access and opportunity for all applicants. Join us in advancing the next generation of genomic technologies and shaping the future of precision health. #J-18808-Ljbffr Sarmal