Scientist Oncology Drug Discovery (Cell-Based Assays)

Job Description

Job Description

Details for the position are as follows:

• 6-month contract to start with the strong possibility of extension or conversion depending on performance and business needs
• $60 hr
• Location: Cambridge, MA – 100% onsite
• Interview process: 1-hour virtual interview with a short scientific presentation and panel discussion
• Targeted Start date: November 16.

• We are seeking a highly motivated, lab-based Biologist to join a collaborative, cross-functional team supporting small molecule drug discovery programs within Oncology. This 6-month contract position will focus on advancing drug discovery projects from early research concepts toward clinical candidates.
• The ideal candidate will have strong hands-on experience with cell-based assays, assay development, and an understanding of compound mechanisms of action (MOA). This individual will be responsible for designing and executing experiments, developing and troubleshooting assays, and generating and interpreting data to better understand oncology target biology, compound activity, and potential biomarkers.
• This role offers the opportunity to work across diverse oncology research projects and collaborate with scientists from multiple disciplines to support the identification and advancement of promising drug candidates.
• Oncology Target Biology: Validate oncology targets using preclinical models, including cell lines and organoids, and develop derivative models using genetic approaches.
• Cell-Based Assay Development: Develop, optimize, and troubleshoot cell-based phenotypic assays, including proliferation, survival, cell cycle, and apoptosis assays using 2D/3D culture systems and clonogenic formats.
• Experimental Design & Execution: Design and conduct experiments to investigate compound mechanisms of action (MOA), evaluate biological responses, and identify potential biomarkers.
• Laboratory Techniques: Utilize techniques such as Western blotting, ELISA, flow cytometry, RT-PCR, and high-content imaging to support experimental studies and biological characterization.
• Data Analysis & Interpretation: Generate, analyze, and interpret experimental data to assess compound behavior, understand biological mechanisms, and support drug discovery decisions.
• Scientific Communication & Collaboration: Present experimental findings and communicate results effectively with cross-functional project teams to support ongoing oncology research programs.
• Documentation & Record Keeping: Maintain accurate and organized experimental records in accordance with laboratory best practices, including generating high-quality data to support AI applications and deployment.

• Bachelor’s or Master’s degree in biology or a relevant scientific field with 4-6 years post-graduation research experience, or PhD with 2+ years post-graduation research experience.
• Strong understanding of compound mechanisms of action (MOA) and cellular responses to drug treatment.
• Hands-on experience developing, performing, and troubleshooting cell-based assays.
• Experience with experimental design, data analysis, and interpretation in a laboratory research environment.
• Familiarity with molecular and cellular biology techniques such as Western blotting, ELISA, flow cytometry, RT-PCR, and high-content imaging.
• Experience working with cell lines, 2D/3D cell culture systems, or organoids is highly relevant.
• Ability to collaborate effectively with scientists across multiple disciplines and communicate scientific findings clearly.
• Experience in oncology research or small molecule drug discovery is highly desirable.

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