Sr. Clinical Bioinformatics Engineer

Sr. Clinical Bioinformatics Engineer Locations: Los Angeles, California Job Category: Professional Position Type: Full-Time Shift: Days Job Description Join a team that's shaping the future of pediatric care. Children’s Hospital Los Angeles is consistently ranked among the top 10 children's hospitals in the nation, delivering world-class care through more than 350 specialized programs and services. Here, world-class experts in medicine, research, and education work together to deliver family-centered care to more than 155,000 patients each year. At CHLA, your work will help build brighter tomorrows for the children and families we serve. Overview Schedule: Monday–Friday, 9:00 AM–5:00 PM This position offers a hybrid work arrangement, with the opportunity to work remotely up to 2 days per week. Purpose Statement/Position Summary: We are seeking a highly skilled and motivated Genomic Data Analyst/Scientist with a strong background in bioinformatics, including extensive experience in rare and common variant calling from whole‑genome sequencing data, variant classification, and genomic data management. The Scientist will serve as a subject matter expert, performing both independent and collaborative bioinformatics analyses, including methods research and methods development.The successful candidate will join a multidisciplinary research team focused on deeply phenotyping Hispanic families with one or more children diagnosed with autism spectrum disorder. Candidates should hold a Ph.D. in Genomics, Bioinformatics, Computational Biology, or a related field, with at least three years of postdoctoral or industry experience in genomic bioinformatics. The Sr. Clinical Bioinformatics Engineer serves as an expert who will lead the work on developing and utilizing new and existing computational tools and systems to assist with the analysis and interpretation of clinical data from various next-generation sequencing based assays and other laboratory developed tests. The Clinical Bioinformatics Engineer, Sr will not only be able to use established workflows and software packages, but also be able to develop customized pipelines, databases and novel methodologies as needed. The Clinical Bioinformatics Engineer, Sr is expected to play a leadership role in managing and mentoring junior bioinformatics engineers, and is encouraged to participate, to assist and to lead various clinical and research projects that will lead to novel clinical insights and publications. The Clinical Bioinformatics Engineer, Sr will serve in a project management capacity for projects across the team and will lead and manage diverse cross-disciplinary teams from initiation to implementation. He/she also provides research support to investigators and assists in training investigators and new users to use bioinformatics applications and databases. The Sr. Clinical Bioinformatics Engineer must be able to perform all responsibilities of the Clinical Bioinformatics Engineer II job description. All responsibilities listed in this description are additional. Minimum Qualifications/Work Experience: Required: Demonstrated ability to manage multiple large-scale projects and overlapping deadlines and dependencies. Excellent communication skills, both written and verbal is required. Familiarity with various publicly available databases such as HGMD, ClinVar, TCGA, ICGC, Ensembl, Refseq, UCSC, 1000 Genome and ExAC. Capable of designing and executing large-scale projects and programs. Demonstrated ability to implement and understand complex algorithms. Ability to develop and implement methods/algorithms and integrate multiple tools and software resources into software solutions/pipelines. Familiarity with laboratory testing methods and genomic and other laboratory data is desired. Proficiency in various open source and commercially available bioinformatics resources, platforms and software required Demonstrated ability to organize data and implement algorithms for the analysis of large-scale complex data sets including statistical tests, quality analysis, and machine learning, artificial intelligence, blockchain and or natural language processing. Preferred: Intermediate to advanced level linux background and bash scripting experience. Intermediate to advanced object-oriented programming and scripting language experience. Intermediate to advanced (structured and/or unstructured) database development experience. Beginner to intermediate level experience with developing and deploying CI/CD pipelines. Intermediate to advanced level experience with various Cloud Services such as AWS Code Pipeline, Code Commit, Fargate and Lambda. Intermediate to advanced high performance computing cluster experience and working with schedulers such as Slurm or LSF. Intermediate to advanced level experience with a workflow definition language such as Nextflow. Intermediate to advanced level experience working with containerization technology such as Docker or Singularity. Intermediate to advanced level experience developing and automating custom data processing pipelines for production environment. Experience developing web applications and dashboards desired. Education/Licensure/Certification: Bachelor’s degree highly desired with 7+ years of related work experience, or master’s degree with 5+ years of related work experience. Advanced degree preferred. Pay Scale Information

USD $124,488.00 - USD $165,984.00

CHLA values the contribution each Team Member brings to our organization. Final determination of a successful candidate’s starting pay will vary based on a number of factors, including, but not limited to, education and experience within the job or the industry. The pay scale listed for this position is generally for candidates who meet the specified qualifications and requirements listed on this specific job description. Additional pay may be determined for those candidates who exceed these specified qualifications and requirements. We provide a competitive compensation package that recognizes your experience, credentials, and education alongside a robust benefits program to meet your needs. About Us CHLA is a leader in pediatric and adolescent health, in our community, across the nation, and around the world . As a premier Magnet®-recognized teaching hospital, CHLA offers an environment rooted in learning, collaboration, and compassionate care. . We are home to groundbreaking research, clinical innovation, and a culture that supports personal and professional growth. Since 1932, CHLA has been affiliated with the Keck School of Medicine of the University of Southern California. Through this partnership and our own enduring mission, we remain committed to creating hope and building healthier futures. CHLA is an Equal Opportunity Employer At Children’s Hospital Los Angeles, our work matters. And so do each and every one of our valued team members. We consider qualified applicants for all positions without regard to race, color, religion, creed, national origin, sex, gender identity, age, physical or mental disability, sexual orientation, marital status, veteran or military status, genetic information or any other legally protected basis under federal, state or local laws, regulations or ordinances. We will also consider for employment qualified applicants with criminal history, in a manner consistent with the requirements of state and local laws, including the LA City Fair Chance Ordinance and SF Fair Chance Ordinance. Qualified Applicants with disabilities are entitled to reasonable accommodation under the California Fair Employment and Housing Act and the Americans with Disabilities Act. Please contact CHLA Human Resources if you need assistance completing the application process. Our various experiences, perspectives and backgrounds allow us to better serve our patients and create a strong community at CHLA. Children's Hospital Los Angeles