Senior Director, Clinical Operations, Global Clinical Vendor Contracts & Budgets

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS‑addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins, including daraxonrasib (RMC‑6236), elironrasib (RMC‑6291), zoldonrasib (RMC‑9805), and RMC‑5127, all currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. Opportunity This is a unique opportunity for a Clinical Operations Professional who brings innate leadership and organizational skills, technical expertise in clinical oncology drug development, and experience in negotiation, execution and management of clinical trial vendor agreements and budgets. The leadership role ensures alignment with strategic objectives, regulatory requirements and study timelines while drawing on deep expertise in managing complex trials, contract negotiations, budget development, risk mitigation and cross‑functional collaboration to deliver the highest quality, on‑time clinical studies for Revolution Medicines. Responsibilities Develop and execute the global clinical outsourcing strategy, aligning vendor governance, contracting and operational frameworks with company objectives and clinical development priorities. Provide strategic leadership and oversight for the Global Clinical Vendor Contracts function, driving operational excellence, scalable processes, standardized policies and continuous improvement across the end‑to‑end contract lifecycle. Act as the executive sponsor for global clinical vendor relationships, establishing governance models, performance metrics (KPIs), preferred provider strategies and risk management practices that optimize quality, cost and delivery. Lead cross‑functional partnerships with Clinical Operations, Biometrics, Data Management, Safety, Regulatory, Quality, Finance, Legal and IT to develop outsourcing strategies, negotiate commercial terms and ensure seamless execution of clinical programs. Direct strategic sourcing, RFP development, vendor evaluation, selection and contract negotiations, including Master Service Agreements, work orders, change orders, consulting agreements and clinical budgets. Build and sustain high‑performing vendor partnerships through proactive performance management, compliance oversight, issue resolution and executive‑level governance, ensuring vendors consistently meet contractual and operational expectations. Anticipate, assess and resolve complex business, operational and vendor relationship challenges, serving as the senior escalation point for critical outsourcing and contract execution issues. Champion innovation by monitoring industry trends, benchmarking best practices and implementing new technologies, contracting models and process improvements that enhance efficiency, scalability and business performance. Lead, mentor and develop a high‑performing Vendor Contracts organization by fostering collaboration, accountability, strategic thinking and continuous professional growth while building organisational capabilities for future business needs. Ensure appropriate vendor qualification, regulatory compliance, financial stewardship and contractual risk mitigation through strong collaboration with Quality Assurance, Legal, Finance and other key stakeholders. Represent Global Clinical Vendor Outsourcing in senior leadership discussions, contributing strategic expertise, data‑driven insights and executive recommendations that support enterprise decision‑making and successful delivery of the clinical development portfolio. Required Skills, Experience and Education BS, plus 17+ years of experience or equivalent and 10+ years in a leadership role. Advanced degree desirable: Master with 15+ years experience and 8+ years leadership or Doctoral with 13+ years experience and 6+ years leadership. Expertise in large, multi‑site, early/late phase and post‑marketing oncology clinical trials. Experience working in growing companies or departments that have created successful processes. Clear understanding of clinical contracting and budget process. Excellent organizational and time‑management skills with strong attention to detail and proven ability to handle multiple tasks efficiently. Comfortable in a fast‑paced company environment and able to adjust workload based on changing priorities. Experience leading strategic change‑management initiatives across clinical operations or equivalent. Excellent interpersonal, verbal and written communication skills, with the ability to interact with colleagues and partners at all levels of experience. Proven understanding of global site budget and contract negotiations to achieve optimal results and develop plans to meet strategic and operational targets in alignment with Revolution Medicines. Ability to produce, interpret and share complex performance information and communicate it to a wide variety of audiences. Experience with hiring, training, developing, mentoring and motivating team members to the highest level of performance. An innovative, driven and effective person with a "can do" attitude. A goal‑oriented person who can plan for the long‑term and execute stated objectives. Travel may be required (~25%). Preferred Skills Familiarity working with financial and legal systems/portals. Knowledge and/or familiarity with Ex‑US region(s) clinical trial operations. Working knowledge of applicable regulatory, ICH and GCP guidelines. Global project level budget builds. Advanced knowledge of Microsoft Word, Excel, PowerPoint and Smartsheet. Base pay salary range for full‑time position in Redwood City, CA: $244,000 – $305,000 USD. Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition and veteran status. Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using its website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact View email address on click.appcast.io. We are aware of recent recruitment scams in which individuals or organizations falsely represent themselves as being affiliated with Revolution Medicines. These scams may appear as false job advertisements or unsolicited contacts through communication or chat platforms, email, phone or text message. Please note that Revolution Medicines does not extend unsolicited employment offers and will never ask candidates to provide financial information, purchase equipment or pay fees as part of the hiring process. All legitimate communication from Revolution Medicines will come from an official @revmed.com email address. If you believe you have been contacted by someone impersonating a Revolution Medicines recruiter, please report it to View email address on click.appcast.io so we can share these impersonations with our IT team for tracking and awareness. #J-18808-Ljbffr Revolution Medicines