Staff, Full Stack Engineer

Enterprise AI (EAI) builds AI products that combine real modelling work with user-facing applications, and ships them to production. Full Stack Engineers move across data, models, platforms, APIs and interfaces in a single workflow. In our operating model, digital workers do much of the hands-on build. They generate services, APIs, interface components and tests, run evaluations and monitor what is in production. Our engineers set the architecture and standards that work is built to, and own the quality of what ships.EAI products and agents draw on a governed context layer that makes data, meaning, permissions and history retrievable at the moment they are needed. Full Stack Engineers build the products and agents that consume it, and decide how that context reaches users.The Staff Full Stack Engineer sets technical direction for the AI product stack across EAI. The role is accountable for the integration and orchestration architecture through which EAI products and agents draw on the governed context layer, and is EAI's internal authority on how AI capabilities reach users.Sets multi-quarter technical direction for the AI product stack across EAI: modelling workflows, platforms and APIs, AI-powered interfaces and the agentic systems that connect them.Owns the integration and orchestration architecture through which EAI products and agents draw on the governed context layer, and defines the standards engineers and digital workers build to.Defines EAI's agentic research and development practice for continuous experimentation, auto-research and agent-driven application development, and develops the senior engineers who carry it forward.Key Responsibilities:Technical Strategy & Research PracticeSet multi-quarter technical direction for the AI product stack across EAI, and lead the most ambitious end-to-end bets, turning vague, high-stakes problems into shipped systems with durable impact.Define EAI's agentic research practice for continuous experimentation and auto-research, evolving production models, and using agents to drive research and application iteration.Agent-Operated EngineeringSet the operating model for agent-generated engineering work: what digital workers build and change on their own, what requires human approval, which evaluation gates their work must pass and how incidents escalate.Set the AI-assisted development standard: the tooling, workflows and practices for coding and research agents, with measurable impact on velocity and quality.Platforms & APIsDefine API and platform architecture standards adopted across EAI engineering teams, covering contracts, authentication, versioning and non-functional requirements.Drive architectural coherence across modelling pipelines, evaluations, retrieval, agent orchestration, application services, frontends, data and observability, without becoming a bottleneck. Shape platform decisions that measurably improve reliability and developer productivity.AI Integration & ContextShape EAI's AI integration architecture: LLM selection, orchestration patterns, retrieval and tool use, and LLMOps standards.Own how EAI products and agents draw on the governed context layer over standard protocols such as MCP, with consistent patterns for retrieval, permissions and provenance.AI-Native ExperienceDefine EAI's frontend engineering standards and shape how AI capabilities reach users across the portfolio.Lead EAI's approach to AI-native UX: designing for non-deterministic, agent-driven interfaces, with confidence signals, error states, provenance and human-override paths that earn user trust.LLMOps & System HealthDefine EAI's LLMOps standards for observability, evaluation and governance of production AI systems, and lead enterprise-scale evaluation and monitoring infrastructure.Own long-term system health across reliability, performance, cost, security, model behaviour, safety and abuse, as EAI's authority on production AI system health.Standards & Technical LeadershipDefine full-stack engineering standards adopted across EAI pods, written to be followed by humans and digital workers alike.Shape EAI's developer tooling and shared component strategy, leading foundational investments such as evaluation frameworks, agent runtimes, experiment management, internal SDKs and shared components that reduce duplication and change how teams build.Develop senior engineers towards greater architectural independence, and partner with research, product, design, data engineering and platform teams on the hardest product problems.Why You?Basic Qualification We are seeking professionals with the following required skills and qualifications to help us achieve our goals: Bachelor's degree in Computer Science, Data Science, Statistics, Applied Mathematics or a related quantitative field, or equivalent practical experience. 10+ years of experience in applied machine learning (ML) or data science and full-stack engineering, including experience building and operating user-facing AI products.Experience across the AI product stack, including modelling pipelines, evaluations, platforms and APIs, modern web frameworks, and data and cloud infrastructure.Experience designing and operating production AI products, including large language model (LLM) selection and integration, orchestration and tool-use architectures, retrieval and context integration using protocols such as Model Context Protocol (MCP), safety, and cost, latency and quality optimisation.Experience defining API, platform and frontend engineering standards for multiple teams, including interfaces designed for non-deterministic, agent-driven behaviour.Experience building large language model operations (LLMOps), evaluation and monitoring infrastructure for production AI systems.Experience defining and scaling agentic research and product workflows, such as auto-research, continuous evaluation and agent-driven application development.Experience setting multi-quarter technical strategy across multiple engineering teams.Preferred Qualification If you have the following characteristics, it would be a plus: Master's or PhD strongly preferred, in Computer Science, Data Science, Statistics, Applied Mathematics or a related quantitative field, or equivalent practical experience.Prior Staff, or equivalent, experience at an organisation shipping non-trivial AI products that combine modelling and full-stack delivery.Defined organisation-wide engineering strategy, particularly for agentic research and product workflows, and seen it through to measurable outcomes.Experience in a regulated industry, such as life sciences, where data integrity and auditability are mandatory.Public technical contributions, such as talks, writing or open source, on AI-native, agent-augmented engineeringExperience defining API and platform architecture standards for multiple engineering teams and making platform decisions to improve reliability and developer productivity.Experience with AI integration architecture, including large language model (LLM) selection, orchestration patterns and LLM operations (LLMOps)and implementing evaluation pipelines and AI observability practices across multiple teams.Experience defining frontend engineering standards for AI products and designing non-deterministic, agent-driven user interfaces.Experience defining LLMOps standards, including AI system observability, evaluation and governance and building evaluation and monitoring infrastructure for production AI systems.Experience defining full-stack engineering standards, including standards for agent-generated code.Experience developing developer tooling and shared component strategies.What Success Looks LikeIn the first 12 months, the person in this role will have:Set and begun executing a multi-quarter technical strategy for the AI product stack across EAI.Established the operating model and standards under which engineers and digital workers build across platforms, APIs and interfaces, and led at least one platform investment that changed how teams build.Defined the integration and orchestration architecture through which EAI products and agents draw on the governed context layer, with evaluation and observability standards in production.Defined EAI's approach to agentic research and AI-assisted development, with measurable adoption and impact on velocity and quality.Raised the architectural independence of EAI's senior engineers through standards and coaching.Work Arrangement This role is hybrid and based in the United States. You will spend scheduled time on-site to collaborate and engage with your team. Fully remote arrangements are not available.#Li-GSK#AGTechSkillsAI Platforms, Change Management, Data Analysis, Feature Prioritization, Machine Learning Model Management, ML Platforms, Model Evaluation, Performance Analysis, Product Delivery, Product Design, Product Lifecycle Management (PLM), Product Roadmapping, Roadmap Development, Statistical Analysis, User Needs AnalysisPlease visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees. Why GSK?Uniting science, technology and talent to get ahead of disease together.GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases – to impact health at scale.People and patients around the world count on the medicines and vaccines we make, so we’re committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.If you require an accommodation or other assistance to apply for a job at GSK, please contact the appropriate Recruitment Staff by emailing us at - View email address on click.appcast.io is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.Important notice to Employment businesses/ AgenciesGSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK’s compliance to all federal and state US Transparency requirements. For more information, please visit the Centers for Medicare and Medicaid Services (CMS) website at SummaryLocation: USA - Pennsylvania - Philadelphia; Durham Blackwell StreetType: Full time