Senior / Principal Technical Program Manager, Life Sciences AI

Senior / Principal Technical Program Manager, Life Sciences AI

Cambridge, MA USA; San Francisco, CA USA

Your Impact at LILA

Lila is building a platform where AI and automation co-evolve to solve the hardest problems in medicine. Within Life Science AI (LSAI), Lila develops large-scale generative models and reasoning frameworks — spanning biological sequences, molecular structures, and multimodal experimental data — that power automated scientific discovery and feed Lila's closed-loop "Lab-in-the-Loop" discovery engine. As that work scales, the surface area of cross-functional coordination across model research, evaluation, experimental science, and downstream integration is growing fast.

We are looking for a Senior or Principal Technical Program Manager to join our AI Research team and bring structure, accountability, and delivery cadence to Life Sciences AI. You will be the connective tissue between model researchers, computational and wet-lab scientists, automation and software teams, and the broader Lila organization. The successful candidate thrives in ambiguity, communicates exceptionally well across audiences, and knows how to build clarity and momentum on a fast-paced, rapidly scaling team. In addition, you must be genuinely curious about how foundation models for biology drive scientific discovery and able to clearly articulate what each program is trying to deliver.

What You'll Be Building

• Establish and operate the delivery cadence and rhythm for the Life Sciences AI organization — driving program planning, status, milestone tracking, and risk management across foundation model research, evaluation, and integration with Lila's closed-loop discovery engine.
• Serve as the key communication interface between LSAI and partner organizations (model training, experimental science, automation, software, product, and leadership); set up the organizational information flows that allow this communication to happen with speed at scale.
• Drive accountability across distributed, cross-functional teams without relying on direct authority; build consensus through clear communication and sound judgment.
• Translate research priorities into structured, accountable program execution: define workstreams, milestones, dependencies, and risks across biological sequence design, structure prediction, multimodal scientific reasoning, and other LSAI program areas.
• Partner with experimental scientists and computational biologists to keep the Lab-in-the-Loop feedback cycle on schedule — ensuring data generation, model training, and experimental validation stay synchronized.
• Implement best practices for rapid experimentation and iteration, enabling new LSAI workstreams to ramp efficiently as the team grows.
• Develop clear documentation and reporting to communicate vision, track progress, and align LSAI work with broader AI Research and company-wide priorities; represent program status and risks accurately even when the picture is uncertain or evolving.

What You'll Need to Succeed

• Bachelor's or Master's degree in Computer Science, Engineering, Life Sciences, or a related field.
• 8+ years of program or project management experience in technology, AI/ML, or life sciences environments.
• Proven experience leading cross-functional programs and driving them to successful completion under tight delivery timelines.
• Strong analytical and problem-solving skills, with the ability to turn technical and scientific requirements into actionable program roadmaps.
• Track record of driving accountability without direct authority across engineering, research, and scientific stakeholders.
• Exceptional written and verbal communication skills; track record of producing executive-quality documents, roadmaps, and updates that drive decisions.

Bonus Points For

• Direct experience in AI/ML research or product organizations, ideally in a program management or research operations capacity.
• Working familiarity with foundation models, generative AI, or ML for biology — sufficient to engage credibly with researchers and ask good questions.
• Exposure to experimental science workflows or closed-loop discovery systems where computational and wet-lab work iterate together.
• Experience managing programs that span research, evaluation, and integration workstreams in fast-moving technical environments.
• Enthusiastic about emerging technologies and experienced in driving rapid experimentation and program iteration.

Compensation We offer competitive base compensation with bonus potential and generous early-stage equity. Your final offer will reflect your background, expertise, and expected impact. U.S. Benefits. Full-time U.S. employees receive a comprehensive benefits program including medical, dental, and vision coverage; employer-paid life and disability insurance; flexible time off with generous company wide holidays; paid parental leave; an educational assistance program; commuter benefits, including bike share memberships for office based employees; and a company subsidized lunch program. International Benefits. Full-time employees outside the U.S. receive a comprehensive benefits program tailored to their region. USD salary ranges apply only to U.S.-based positions; international salaries are set to local market.

Expected Base Salary Range

$192,000 - $306,000 USD

About LILA

Lila Sciences is building Scientific Superintelligence™ to solve humankind's greatest challenges. We believe science is the most inspiring frontier for AI. Rather than hard-coding expert knowledge into tools, LILA builds systems that can learn for themselves.

LILA combines advanced AI models with proprietary AI Science Factory™ instruments into an operating system for science that executes the entire scientific method autonomously, accelerating discovery at unprecedented speed, scale, and impact across medicine, materials, and energy. Learn more at

Guided by our core values of truth, trust, curiosity, grit, and velocity, we move with startup speed while tackling problems of historic importance. If this sounds like an environment you'd love to work in, even if you don't meet every qualification listed above, we encourage you to apply.

We're All In

Lila Sciences is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

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A Note to Agencies

Lila Sciences does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Lila Sciences or its employees is strictly prohibited unless contacted directly by Lila Science's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Lila Sciences, and Lila Sciences will not owe any referral or other fees with respect thereto.