Sign up to access all features of our service.
  • Job search
  • Favorites
  • Create a CV
    New
  • Salaries
  • Subscriptions

Research Leader / Senior Scientist (Computational Drug Design), Cambridge, MA

Isomorphic Labs

Isomorphic Labs seeks a Research Leader or Senior Scientist in computational drug design to provide scientific expertise and strategic direction for drug discovery projects. The role combines computational chemistry leadership with AI platform enhancement, working at the intersection of machine learning and rational drug design.

Responsibilities

  • Provide scientific leadership and strategic direction for portfolio drug discovery programs
  • Guide projects from early stage through clinical candidate selection
  • Enhance the computational drug design platform using technical expertise
  • Partner with machine learning scientists to refine algorithms and models
  • Apply innovative computational approaches to design novel molecules

Requirements

  • Advanced degree in computational chemistry, chemistry, or related field
  • Extensive experience in computational drug design and molecular modeling
  • Demonstrated expertise in applying computational methods to drug discovery projects
  • Strong understanding of machine learning applications in chemistry
  • Ability to think critically and innovate in complex scientific environments
  • Experience guiding projects from initiation through candidate selection
  • Collaborative mindset with cross-functional team engagement
Vacancy posted a month ago
Similar jobs that could be interesting for youBased on the Research Leader / Senior Scientist (Computational Drug Design), Cambridge, MA in Cambridge, MA vacancy
  • Research Leader / Senior Scientist (Computational Drug Design), Cambridge, MA Cambridge, MA Isomorphic Labs is applying frontier AI to help unlock deeper scientific insights, faster breakthroughs, and life-changing medicines with an ambition to solve all disease. The... 
    Senior
    Contract work
    Work at office
    3 days per week

    Isomorphic Labs

    Cambridge, MA
    4 days ago
  • $149k - $237k

     ...TitleSenior Clinical Scientist (Cambridge, MA)Job DescriptionSenior...  ...in the Innovation & Design Department reporting...  ...participate in cutting-edge research in robotics and the...  ...with key opinion leader physicians, including...  ...Vets and maintains a drug-free workplace.Job SummaryJob... 
    Senior
    Full time
    Work at office
    Immediate start
    Work visa
    Relocation package
    3 days per week

    Philips

    Cambridge, MA
    2 days ago
  • $157k - $249k

    Job TitleSenior Scientist - Physical AI for Surgical Robotics (Cambridge, MA)Job DescriptionSenior...  ...(VLA) models.Design and evaluate AI solutions...  ...to translate research concepts into...  ...PhD in Robotics, Computer Science, Artificial...  ...and maintains a drug-free workplace.Job... 
    Senior
    Full time
    Work at office
    Immediate start
    Work visa
    Relocation package
    3 days per week

    Philips

    Somerville, MA
    2 days ago
  • ## Senior Scientist, Cancer Immunology Translational ResearchCambridge Crossing - MA - US* Design and develop biomarker, pharmacodynamic, and target...  ...assays to understand drug mechanism of action and response...  ...1+ year in translational research / translational medicine.*... 
    Senior
    Full time
    Contract work
    Temporary work

    Bristol-Myers Squibb

    Cambridge, MA
    5 days ago
  • $136k - $264k

    (Senior) Scientist, Multimodal Biological Reasoning Cambridge, MA USA Pioneering Intelligence builds on Flagship...  ...-edge science and computational ventures, harnessing...  ...fundamental research and create a portfolio...  ...Key Responsibilities Design technical architecture... 
    Senior

    Flagship Pioneering

    Cambridge, MA
    3 days ago
  • $168k - $252k

     ...seeking a scientific leader to accelerate the...  ...systems across drug discovery....  ...intersection of Computational Drug Design, project teams, Data...  ...scientifically rigorous AI co-scientists that enhance...  ...across Discovery Research.Lead Platform...  ...scientists, and senior leaders across a... 
    Senior
    Full time
    Summer work
    Remote work
    Flexible hours
    2 days per week
    3 days per week

    Vertex Pharmaceuticals

    Boston, MA
    1 day ago
  • $144.8k - $217.2k

     ...highly motivated and experienced computational chemist to join our Computational Drug Design group in Boston. This...  ...skills and the ability to guide scientists in drug discovery.This is a Boston...  ...with medicinal chemists and other research team members to generate design... 
    Full time
    Summer work
    Remote work
    Flexible hours
    2 days per week
    3 days per week

    Vertex Pharmaceuticals

    Boston, MA
    2 days ago
  • $125k - $175k

     ...pioneering the integrative design and deployment of fully programmable...  ...delivery, and advanced computational approaches to design...  ...and scientifically rigorous Senior Scientist to join the Analytical Sciences...  ...analytical methods for RNA drug substance, lipid nanoparticle... 
    Senior
    Contract work
    Local area

    Sail Biomedicines, Inc.

    Cambridge, MA
    3 days ago
  • $126k - $159.5k

    FL114: Senior Scientist, Therapeutics Engineering Cambridge, MA USA About FL114: FL114 is an...  ...experimental and computational scientists...  ...cutting-edge assays. Design, procurement, and...  ...scientific data to senior leaders, teams and...  ...Industry experience in drug discovery or... 
    Senior

    Flagship Pioneering

    Cambridge, MA
    1 day ago
  • $100k - $181.5k

    Pioneering Medicines: Scientist / Sr. Scientist,...  ...(T-cell focused) Cambridge, MA USA About...  ...Pioneering’s in-house drug development unit,...  ...collaborative Scientist/Senior Scientist to join...  ...supports translational research and immunological...  ...by scientific leaders to develop experience... 
    Senior

    Flagship Pioneering

    Cambridge, MA
    1 day ago
  • $100k - $180k

    (Senior) Scientist, Optical Technologies Cambridge, MA USA Help Expand What We Can See in Biology At Flagship Pioneering...  ...collaborations. Responsibilities Design and execute experiments using advanced...  ..., or highly interdisciplinary research environments. Why Join FL120?... 
    Senior
    Full time
    Part time
    H1b
    Local area
    Relocation
    Work visa

    Flagship Pioneering

    Cambridge, MA
    2 days ago
  • $180k - $258.5k

     ...to enable generative design. Expedition...  ...motivated and innovative (Senior) Scientist, Machine Learning to...  ...quantum chemistry, and computational drug discovery to drive...  ...projects in a fast-paced research environment.KEY...  ...collaboration skillsLOCATION: Cambridge, MAABOUT FLAGSHIP... 
    Senior

    Seres Therapeutics

    Somerville, MA
    3 days ago
  • $141k - $171k

     ...with AWS/cloud computing, version control...  ...team to design, analyze, and interpret...  ...variety of research and preclinical...  ...with experimental scientists to ensure that...  ...audiences, including senior leadership, to...  ...in Somerville, MA, with an...  ...group supports drug candidate programs... 
    Senior
    Local area
    2 days per week
    3 days per week

    Tessera Therapeutics

    Somerville, MA
    2 days ago
  • $46 - $60 per hour

    Cambridge, MA USA COMPANY DESCRIPTION Mirai Bio is a privately-held, Flagship...  ..., modular targeted particle design, and integrated translation...  ...a contract Associate Scientist/Scientist I to join the Translational...  ...support in vivo laboratory research activities toward the... 
    Hourly pay
    Contract work
    For contractors

    Flagship Pioneering

    Cambridge, MA
    3 days ago
  • $220k - $270k

    Principal or Senior Principal Scientist - Peptide & Bioconjugate Drug Discovery Does it excite you...  ...is establishing new research units in Cambridge, Massachusetts. We...  ...functional stakeholders in computational chemistry, protein...  ...in peptide design, solid‑phase peptide... 
    Senior

    Zealand Pharma U.S., Inc.

    Cambridge, MA
    3 days ago
  • $144.8k - $217.2k

     ...Vertex Pharmaceuticals seeks a computational chemist to lead drug design initiatives using molecular modeling, cheminformatics, and AI methods. The role...  ...hit/lead identification programs, mentoring junior scientists, and collaborating across discovery teams in Boston on... 

    Vertex Pharmaceuticals

    Boston, MA
    24 days ago
  • Isomorphic Labs is hiring a Research Leader / Senior Scientist (Computational Drug Design) in Cambridge, MA. You will guide AI-enhanced drug discovery, orchestrating projects across computational chemistry and ML teams while mentoring 2-3 scientists. The role emphasizes... 

    Isomorphic Labs

    Cambridge, MA
    4 days ago
  • $142.5k - $256.5k

     ...s Therapeutics Research group is seeking...  ...Principal Scientist to support computational protein design across therapeutic...  ...and technical leader for computational...  ...partners, and senior scientific stakeholders...  ...-free, and drug-free work...  ...SummaryLocation: Cambridge, Massachusetts;... 
    Permanent employment
    Full time
    Work at office
    Work from home

    Moderna

    Somerville, MA
    4 days ago
  • Alsym Energy is seeking a Computational Materials Scientist to design cathode and anode materials for sodium‑ion batteries. You will join the Materials Simulation team and shape research priorities by combining atomistic modeling with materials chemistry to improve energy... 
    Senior

    Alsym Energy

    Malden, MA
    2 days ago
  •  ...unmet medical needs. Our Cambridge, MA site is dedicated to cutting-edge research aligned with the...  ...requires an independent bench scientist and strategic thinker...  ...delivery, including the design, engineering, and...  ...industry experience in drug discovery. Demonstrated... 
    Senior

    Simcere Pharmaceutical Group

    Cambridge, MA
    5 days ago
  • Alsym Energy seeks a Computational Physical Chemist to shape electrolyte discovery and development. You will blend physical chemistry with...  ...safety. Join the Discovery and Early Prototyping team to own research questions from hypothesis to experimental validation, driving... 
    Senior

    Alsym Energy

    Malden, MA
    4 days ago
  • $138k - $184.5k

     ...This Role Biogen is presently looking to fill a Senior Scientist position within its Parenteral Formulation and Drug Product Development group. The candidate will be...  ...communication skills.   What You'll Do Design and execute formulation and process development... 
    Senior
    Full time
    Temporary work
    Local area

    Biogen

    Cambridge, MA
    2 days ago
  • $168k - $252k

     ...seeking an accomplished Senior Principal Scientist with proven record of...  ...deploying scientific computational methods and agentic AI systems for drug discovery. In this...  ...computational sciences, research teams, and Digital...  ...firm grasp of system design principlesExpertise in... 
    Senior
    Full time
    Summer work
    Remote work
    Flexible hours
    2 days per week
    3 days per week

    Vertex Pharmaceuticals

    Boston, MA
    1 day ago
  • $117k - $157k

     ...are seeking a highly motivated Scientist II to join our Technical Development team in Cambridge, MA, focused on oligonucleotide (Antisense...  ...is an exciting opportunity to design and develop robust, scalable...  ...new medicines across various drug modalities. We are driven by... 
    Full time
    Temporary work
    Local area

    Biogen

    Cambridge, MA
    2 days ago
  • $137k - $215.27k

     ...seeking a skilled cheminformatic scientist to join Takeda’s...  ...integrating cheminformatics, computational chemistry, and machine learning to accelerate drug design. The candidate will collaborate...  ...cycle.This role is based in Cambridge, MA.Takeda Compensation and Benefits... 
    Senior
    Minimum wage
    Local area

    Takeda

    Boston, MA
    1 day ago
  •  ...are seeking an experienced Senior Scientist to join the Computational Biology, Pharma R&D team....  ...actionable insights for drug discovery and development...  ...building next-generation research tools that enhance the...  ...technical requirements to design well-scoped analytical plans... 
    Senior
    Full time

    Tempus

    Boston, MA
    2 days ago
  • $216k

     ...Boston, MA Full time REQ-0000137632...  ...outstanding opportunity for a Senior Principal Scientist to join the...  ...Scientist will support research that is focused on advancing...  ...encompass the design, modeling, calibration...  ...with theoretical and computational approaches, and evaluating... 
    Senior
    Full time
    Temporary work
    Work at office
    Remote work
    Shift work
    Day shift

    University of Washington

    Boston, MA
    2 days ago
  • $108k - $162k

     ...Vertex Pharmaceuticals seeks a computational chemist to advance drug discovery through molecular modeling, cheminformatics, and AI-enabled design methods. The role involves collaborating with interdisciplinary teams to identify and optimize drug candidates while contributing... 

    Vertex Pharmaceuticals

    Boston, MA
    10 days ago
  • $114.6k - $234.6k

     ...responsible AI. As a Senior Applied Scientist on the team, you will...  ...benchmarks, design experiments, build evaluation...  ...at the point where research results become product...  ...PhD in Computer Science, Machine Learning...  ...health mandates, and/or drug testing requirements.... 
    Senior
    Temporary work
    Flexible hours

    Oracle

    Boston, MA
    4 days ago
  • $216k - $297k

    Principal ML Scientist, Multimodal Biological...  ...Reasoning Cambridge, MA USA The Role...  ...‑scale model design and ensure the...  ...experience in computational biology, AI‑for...  ..., AI‑enabled drug discovery, translational...  ...with ML researchers, data...  ...venture creation leaders. Comfort operating... 

    Flagship Pioneering

    Cambridge, MA
    5 days ago

Do you want to receive more vacancies?

Subscribe and receive similar vacancies to Research Leader / Senior Scientist (Computational Drug Design), Cambridge, MA. Be the first to apply!