Sign up to access all features of our service.
  • Job search
  • Favorites
  • Create a CV
    New
  • Salaries
  • Subscriptions

Principal Scientist I

Novartis AG

PK Sciences Project Team Representative

We are seeking an enthusiastic and motivated PK Sciences project team representative to develop and implement translational or clinical pharmacology strategies to support the pursuit of transformative new medicines through late clinical development. Our unique organizational structure enables colleagues to work seamlessly in the translational and/or clinical space, offering opportunities for development and bench-to-bedside-to-bench translation. Experience in late discovery into clinical development is preferred. The scope of the role potentially includes small molecules, biologics/therapeutic proteins, antibody drug-conjugates, radioligand therapies and/or cell therapies across major therapeutic areas in Novartis, including oncology, immunology, cardiovascular renal metabolism, neuroscience, and global health. This position drives close interdisciplinary collaboration among the PK Science disciplines, Drug Disposition (ADME, BA), Modeling & Simulation (M&S), and Operations through PK science sub-teams to achieve a holistic and integrative perspective of the ADME/clinical pharmacology properties of candidates and drugs. Collaborates effectively with broader, cross disciplinary project teams to ensure PKS strategies are well integrated into project plans and scientific discussions.

Vacancy posted 23 hours ago
Similar jobs that could be interesting for youBased on the Principal Scientist I in Cambridge, MA vacancy
  • $208k - $286k

     ...Flagship Pioneering is looking for a Principal Scientist specializing in Machine Learning to lead AI projects that impact early-stage ventures. Ideal candidates will possess a strong background in AI/ML and hold a Master’s or PhD. Responsibilities include overseeing technical... 
    Principal

    Flagship Pioneering

    Cambridge, MA
    2 days ago
  • $138.6k - $257.4k

     ...Description SummaryWe are seeking a highly motivated and experienced scientist to lead a small group of biologists with advanced imaging...  ...for patients.Job DescriptionInternal Job Title: Senior Principal Scientist/Associate DirectorPosition Location: Cambridge, MA,... 
    Principal
    Full time

    Novartis

    Somerville, MA
    4 days ago
  • $115k - $215k

     ...quantitative proteomics data analysis tools.Domain leadership with cross-functional drug discovery:Highly organized, solutions-oriented scientist with the ability to manage multiple priorities simultaneously while driving innovation in targeted proteomics workflows and... 
    Principal

    Kymera Therapeutics

    Watertown, MA
    19 hours ago
  • $160k - $235k

     ...Sr. Scientist/Principal Scientist, Translational Research and Clinical Biomarkers (Immunology) Boston, MA Salary Band: $160,000-$235,000 Location: Downtown Boston, MA Position Summary Antares Therapeutics is seeking to add an enthusiastic and highly motivated... 
    Principal

    Antares Therapeutics

    Boston, MA
    3 days ago
  • $148.5k - $214.5k

    Job title: Senior Principal Scientist Type 2 ImmunologyLocation:Cambridge, MAAbout the JobImmunology and Inflammation Therapeutic AreaWe have an exciting opportunity to join Sanofi's Translational Biology team as a Senior Principal Scientist within the Type 2 Immunology... 
    Principal
    Full time

    Sanofi

    Somerville, MA
    4 days ago
  • $112.02k - $118.4k

     ...Principal Associate Scientist (Boston, MA) Principal Associate Scientist sought by Ascidian Therapeutics, Inc. to design, validate, execute, and interpret experiments to improve therapeutic performance of designer RNA editing molecules & contribute to characterization... 
    Principal

    Ascidian Therapeutics

    Boston, MA
    23 hours ago
  • $175k - $225k

     ...follow @ScholarRock on X and on LinkedIn.Summary of Position:Scholar Rock is seeking an accomplished and highly collaborative Principal Scientist, Biomarker Development, to provide scientific leadership for biomarker strategy and execution across preclinical programs in... 
    Principal
    Full time

    Scholar Rock

    Somerville, MA
    1 day ago
  • $160k - $224k

    The Role: Generate is seeking an accomplished Principal Scientist to lead Target Binding efforts within our Protein Analytics & Biophysics (PAB) department.This individual will provide scientific and strategic leadership for protein-protein interaction, target-binding,... 
    Principal
    Shift work

    Generate Biomedicines

    Somerville, MA
    19 hours ago
  • $168k - $252k

    Job DescriptionVertex is seeking an accomplished Senior Principal Scientist with proven record of developing, testing and deploying scientific computational methods and agentic AI systems for drug discovery. In this role, you will work across modalities with emphasis on... 
    Principal
    Full time
    Summer work
    Remote work
    Flexible hours
    2 days per week
    3 days per week

    Vertex Pharmaceuticals

    Boston, MA
    1 day ago
  • $146k - $236k

    About Pioneering IntelligencePioneering Intelligence builds on Flagship Pioneering’s legacy of founding cutting-edge science and computational ventures, harnessing recent advances in AI, machine learning, and data to accelerate fundamental research and create a portfolio...
    Principal

    Seres Therapeutics

    Cambridge, MA
    1 day ago
  • $179k - $236k

     ...nonclinical and clinical programs, operating as a hands-on scientific leader. We are looking for an accomplished DMPK and bioanalytical scientist with experience in PK study design, bioanalytical method development, and translational biomarker strategy. This person will... 
    Principal

    Seres Therapeutics

    Cambridge, MA
    2 days ago
  • $146k - $236.5k

    About the Role:FL117, a venture-backed stealth AI x bio company, is seeking a Sr. Scientist / Principal Scientist, Molecular Simulations. Here you will build the physics layer of a drug development AI platform. You will characterize how binders engage their targets and... 
    Principal

    Seres Therapeutics

    Somerville, MA
    2 days ago
  • $168k - $252k

     ...high-value opportunities across the design-make-test-analyze (DMTA) cycle and translate them into scientifically rigorous AI co-scientists that enhance compound design, knowledge synthesis, data interpretation, hypothesis generation, and decision-making. Although the... 
    Principal
    Full time
    Summer work
    Remote work
    Flexible hours
    2 days per week
    3 days per week

    Vertex Pharmaceuticals

    Boston, MA
    1 day ago
  • $108.5k - $201.5k

    Description:Mariana Oncology is seeking a Principal Scientist I, Medicinal Chemistry to join our Discovery Chemistry team. The successful candidate will play a key role in advancing innovative radiopharmaceutical and precision medicine programs, with a focus on peptide-... 
    Principal

    Mariana Oncology

    Watertown, MA
    4 days ago
  • $188k - $259k

    About This Role Biogen is seeking a Sr. Principal Scientist, Oral Drug Product Development to provide scientific and strategic leadership for the development of small molecule oral drug products. This role leads scientific and engineering efforts supporting formulation... 
    Principal
    Full time
    Temporary work
    Local area

    Biogen Idec

    Somerville, MA
    19 hours ago
  • $198.9k - $269k

     ...range of science and engineering domains within Amazon, and you will join the team at the forefront of this research.As a Principal Applied Scientist, you will play a pivotal role in shaping the definition, vision, and development of product features from beginning to... 
    Principal
    Flexible hours

    AmazonWebServices

    Boston, MA
    4 days ago
  • $122.25k - $176.58k

    Job Title: Principal Scientist, Quantitative Systems PharmacologyLocation: Cambridge, MAAbout the job:We are an innovative global healthcare company with one purpose: to chase the miracles of science to improve people’s lives. We’re also a company where you can flourish... 
    Principal
    Full time
    Internship

    Sanofi

    Somerville, MA
    8 hours ago
  • $108.5k - $201.5k

    Job Description SummaryAs a Principal Scientist, you will lead and execute formulation development and characterization strategies for complex biologics—including monoclonal antibodies (mab’s), multispecifics, antibody-drug conjugates (ADCs), and other modalities. You will... 
    Principal
    Full time

    Novartis

    Cambridge, MA
    2 days ago
  • $108.5k - $201.5k

     ...Description SummaryWe are seeking a highly curious, hands-on scientist to help build the next generation of opportunities for Frontier...  ...setting to advance project goals.Job DescriptionInternal Job Title: Principal Scientist IPosition Location: Cambridge, MA, onsiteWe are... 
    Principal
    Full time
    Traineeship

    Novartis

    Somerville, MA
    19 hours ago
  • Sanofi US Cambridge is seeking a Senior Principal Scientist in Type 2 Immunology to lead preclinical programs and translate insights into early clinical strategies across dermatology, gastroenterology, respiratory and rheumatology. You will operate at the interface of cutting... 
    Principal

    Mass Digital Health

    Cambridge, MA
    4 days ago
  • $126k - $234k

     ...of treatment approaches including targeted therapies, immunotherapies, CAR-T, and radioligand therapy. NIBR is seeking an in vivo scientist to join our Oncology Pharmacology team in Cambridge, MA. The successful candidate will join a dynamic, multi-disciplinary team and... 
    Principal
    Full time
    Remote work

    Novartis

    Somerville, MA
    4 days ago
  • $119.7k - $222.3k

     ...preferably in a lead role overseeing ADME/DMPK project strategy in clinical development, or in AI strategy, to be considered for Principal Scientist II. 4+ years of experience to be considered for Senior Principal Scientist.Extensive and in-depth knowledge of... 
    Principal
    Full time

    Novartis

    Cambridge, MA
    3 days ago
  • $208k - $286k

     ...cycles, continuously improving their performance while maintaining exploration of novel directions. We are looking for a Senior Principal Scientist to invent and build the next generation of evolutionary algorithms.In this role you will develop methods that enable... 
    Principal

    Seres Therapeutics

    Somerville, MA
    3 days ago
  • $216k - $297k

     ...reasoning efforts on both the technical and application levels. You will be a hands-on lead for a team of talented machine learning scientists innovating on model architectures that will create best-in-class biological reasoning engines. You will be responsible for... 
    Principal

    Seres Therapeutics

    Cambridge, MA
    4 days ago
  • $142.5k - $256.5k

    The RoleModerna is seeking an accomplished and highly motivated Principal Scientist to join the Antibody Discovery team within Therapeutics Research. Therapeutics Research generates innovative therapeutic concepts and advances them from early scientific idea through First... 
    Principal
    Permanent employment
    Full time
    Work from home

    Moderna Therapeutics

    Cambridge, MA
    2 days ago
  •  ...Principal Scientist Our mission at Asimov is to advance humanity's ability to design living systems, enabling biotechnologies with outsized benefit to society. We're developing a mammalian synthetic biology platform––from cells to software––to enable the design and... 
    Principal

    Asimov

    Boston, MA
    1 day ago
  •  ...therapeutic platform with the potential to address significant unmet medical needs. We are seeking an accomplished and highly collaborative scientist to lead the Cellular Biology function. The ideal candidate will bring deep scientific and technical expertise in bone marrow... 
    Principal

    Trimaren Human Capital Partners, LLC

    Watertown, MA
    19 hours ago
  • $121.28k - $202.13k

     ...success. We’re uniting science, technology, and talent to get ahead of disease together.Find out more:Our approach to R&DPrincipal Scientist (m/f/d) Genomic Technologies, Human Genetics and GenomicsThis position may be based at a GSK R&D site in UK (Stevenage), in USA (... 
    Principal
    Full time
    Work at office
    Local area

    GSK

    Cambridge, MA
    2 days ago
  • $142.5k - $256.5k

    The RoleModerna is seeking a highly motivated Principal Scientist, Mass Spectrometry to join the Cancer Vaccine and Bioinformatics Research (CVBR) team and support preclinical research.This role combines significant hands-on laboratory work with scientific and technical... 
    Principal
    Permanent employment
    Full time
    Work from home

    Moderna Therapeutics

    Cambridge, MA
    4 days ago
  • $176.2k - $277.3k

     ...DescriptionBoston Pharmacokinetics, Dynamics, Metabolism and Bioanalytics - Principal ScientistOur company is a global health care leader with a...  ...a dynamic, strategic thinking and collaborative Principal Scientist (director-level equivalent) to contribute to our company’s... 
    Principal
    Full time
    For contractors
    Local area
    Worldwide
    Flexible hours

    Merck Sharp & Dohme (MSD)

    Boston, MA
    1 day ago

Do you want to receive more vacancies?

Subscribe and receive similar vacancies to Principal Scientist I. Be the first to apply!