Principal Scientist I
Novartis
PK Sciences Project Team Representative
We are seeking an enthusiastic and motivated PK Sciences project team representative to develop and implement translational or clinical pharmacology strategies to support the pursuit of transformative new medicines through late clinical development. Our unique organizational structure enables colleagues to work seamlessly in the translational and/or clinical space, offering opportunities for development and bench-to-bedside-to-bench translation. Experience in late discovery into clinical development is preferred. The scope of the role potentially includes small molecules, biologics/therapeutic proteins, antibody drug-conjugates, radioligand therapies and/or cell therapies across major therapeutic areas in Novartis, including oncology, immunology, cardiovascular renal metabolism, neuroscience, and global health. This position drives close interdisciplinary collaboration among the PK Science disciplines, Drug Disposition (ADME, BA), Modeling & Simulation (M&S), and Operations through PK science sub-teams to achieve a holistic and integrative perspective of the ADME/clinical pharmacology properties of candidates and drugs. Collaborates effectively with broader, cross disciplinary project teams to ensure PKS strategies are well integrated into project plans and scientific discussions.
- ...MassachusettsCompany: Planet Pharma GroupContact: ApplicationsEmail: ****@*****.*** are seeking a highly skilled Scientist to join our Biologics Discovery team and lead antibody discovery efforts. We are looking for someone who thinks carefully about...Principal
$137k - $215.27k
...information I submit in my employment application is true to the best of my knowledge.Job DescriptionAbout the role:The Pharmacovigilance Scientist, Senior Scientist ensures regulatory compliance and safety of Takeda's products by managing large projects, developing innovative...PrincipalMinimum wageLocal area$138.6k - $257.4k
...Description SummaryWe are seeking a highly motivated and experienced scientist to lead a small group of biologists with advanced imaging... ...for patients.Job DescriptionInternal Job Title: Senior Principal Scientist/Associate DirectorPosition Location: Cambridge, MA,...PrincipalFull time$115k - $215k
...quantitative proteomics data analysis tools.Domain leadership with cross-functional drug discovery:Highly organized, solutions-oriented scientist with the ability to manage multiple priorities simultaneously while driving innovation in targeted proteomics workflows and...Principal$148.5k - $214.5k
Job title: Senior Principal Scientist Type 2 ImmunologyLocation:Cambridge, MAAbout the JobImmunology and Inflammation Therapeutic AreaWe have an exciting opportunity to join Sanofi's Translational Biology team as a Senior Principal Scientist within the Type 2 Immunology...PrincipalFull time$160k - $235k
...Position Summary Antares Therapeutics is seeking to add an enthusiastic and highly motivated scientist to its growing Translational Research team. The ideal candidate will have a strong background in immunology/auto-immune diseases, and have prior experience as a subject...Principal$175k - $225k
...follow @ScholarRock on X and on LinkedIn.Summary of Position:Scholar Rock is seeking an accomplished and highly collaborative Principal Scientist, Biomarker Development, to provide scientific leadership for biomarker strategy and execution across preclinical programs in...PrincipalFull time$179k - $236k
...nonclinical and clinical programs, operating as a hands-on scientific leader. We are looking for an accomplished DMPK and bioanalytical scientist with experience in PK study design, bioanalytical method development, and translational biomarker strategy. This person will...Principal$168k - $252k
Job DescriptionVertex is seeking an accomplished Senior Principal Scientist with proven record of developing, testing and deploying scientific computational methods and agentic AI systems for drug discovery. In this role, you will work across modalities with emphasis on...PrincipalFull timeSummer workRemote workFlexible hours2 days per week3 days per week$146k - $236k
About Pioneering IntelligencePioneering Intelligence builds on Flagship Pioneering’s legacy of founding cutting-edge science and computational ventures, harnessing recent advances in AI, machine learning, and data to accelerate fundamental research and create a portfolio...Principal$168k - $252k
...high-value opportunities across the design-make-test-analyze (DMTA) cycle and translate them into scientifically rigorous AI co-scientists that enhance compound design, knowledge synthesis, data interpretation, hypothesis generation, and decision-making. Although the...PrincipalFull timeSummer workRemote workFlexible hours2 days per week3 days per week$214.1k - $337k
Job DescriptionSenior Principal Scientist - Boston, MAOverviewWe are seeking a Senior Principal Scientist to provide scientific and strategic leadership for mass spectrometry-enabled discovery within the Quantitative Biosciences group in Boston. This role will help shape...PrincipalFull timeFor contractorsLocal area$146k - $236.5k
About the Role:FL117, a venture-backed stealth AI x bio company, is seeking a Sr. Scientist / Principal Scientist, Molecular Simulations. Here you will build the physics layer of a drug development AI platform. You will characterize how binders engage their targets and...Principal$188k - $259k
About This Role Biogen is seeking a Sr. Principal Scientist, Oral Drug Product Development to provide scientific and strategic leadership for the development of small molecule oral drug products. This role leads scientific and engineering efforts supporting formulation...PrincipalFull timeTemporary workLocal area$198.9k - $269k
...range of science and engineering domains within Amazon, and you will join the team at the forefront of this research.As a Principal Applied Scientist, you will play a pivotal role in shaping the definition, vision, and development of product features from beginning to...PrincipalFlexible hours$119.7k - $222.3k
Job Description SummaryLocation: Cambridge MAInternal: Principal Scientist I/IILI#-HybridThe individual will provide scientific and operational support to Study Quality and Compliance group within the Toxicology line function of Preclinical Safety (PCS). Key areas of responsibility...PrincipalPermanent employmentFull time$126k - $234k
...of treatment approaches including targeted therapies, immunotherapies, CAR-T, and radioligand therapy. NIBR is seeking an in vivo scientist to join our Oncology Pharmacology team in Cambridge, MA. The successful candidate will join a dynamic, multi-disciplinary team and...PrincipalFull timeRemote work$220k - $270k
Zealand Pharma U.S., Inc. in Cambridge is seeking a Principal or Senior Principal Scientist for Peptide & Bioconjugate Drug Discovery. This role involves leading the development of peptide drug discovery capabilities, with significant responsibilities for strategy and execution...Principal$122.25k - $176.58k
Job Title: Principal Scientist, Systems and Disease BiologyLocation: Cambridge, MAAbout the JobAs a Principal Scientist within our Systems and Disease Biology Cluster, you will decode disease mechanisms at cellular resolution and pioneer AI-powered workflows that accelerate...PrincipalFull time$190.8k - $300.3k
Job DescriptionWe are seeking an accomplished and highly motivated Principal Scientist to provide strategic and scientific biomarker leadership across programs within the Cardiovascular & Metabolic and Infectious Diseases/Vaccines portfolios.This role will lead the design...PrincipalFull timeFor contractorsLocal areaFlexible hours$142.5k - $256.5k
..., as a shared discovery resource. This role is intended for a scientist ready to own and evolve a core discovery capability, led by scientific... ...independence, judgment, and ownership consistent with a Principal Scientist role.Here’s What You’ll Bring to the Table (...PrincipalPermanent employmentFull timeWork at officeWork from home$147.2k - $220.8k
...therapeutics and other emerging modalities. The candidate will work closely with colleagues across Research and Development as a Principal Scientist within Drug Metabolism and Pharmacokinetics (DMPK), providing scientific leadership and strategic guidance to advance...PrincipalFull timeTemporary workWork at officeLocal areaFlexible hours$150.5k - $245.5k
Oncology Imaging Scientific LeadClinical ImagingBuild our future together:The successful candidate will lead the strategy and execution of complex early and late phase oncology imaging in clinical trials where imaging plays a critical role. Imaging includes all modalities...PrincipalFull time$119.7k - $222.3k
...preferably in a lead role overseeing ADME/DMPK project strategy in clinical development, or in AI strategy, to be considered for Principal Scientist II. 4+ years of experience to be considered for Senior Principal Scientist.Extensive and in-depth knowledge of...PrincipalFull time$208k - $286k
...cycles, continuously improving their performance while maintaining exploration of novel directions. We are looking for a Senior Principal Scientist to invent and build the next generation of evolutionary algorithms.In this role you will develop methods that enable...Principal- Sanofi is seeking a Senior Principal Scientist in Cambridge, MA to lead preclinical immunology programs and shape translational strategies that inform clinical development and lifecycle management. You will drive collaborations with Development, Medical Affairs, and Commercial...Principal
- Lila Sciences in Cambridge, MA is looking for a Senior/Principal Scientist specializing in Small Molecule Therapeutics. This role focuses on leading hit identification through DNA-encoded libraries (DEL) and executing robust screening methodologies in collaboration with...Principal
$138.4k - $207.6k
Job DescriptionGeneral Summary:Vertex Pharmaceuticals is seeking a Principal Scientist, Microbiology to join the Analytical Science & Technology (AS&T) organization supporting biologics, cell therapy, and gene therapy programs. This role serves as the microbiology technical...PrincipalFull timeContract workSummer workRemote workFlexible hours2 days per week$216k - $297k
...reasoning efforts on both the technical and application levels. You will be a hands-on lead for a team of talented machine learning scientists innovating on model architectures that will create best-in-class biological reasoning engines. You will be responsible for...Principal$142.5k - $256.5k
The RoleModerna is seeking an accomplished and highly motivated Principal Scientist to join the Antibody Discovery team within Therapeutics Research. Therapeutics Research generates innovative therapeutic concepts and advances them from early scientific idea through First...PrincipalPermanent employmentFull timeWork from home
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