Principal Scientist I
Novartis AG
PK Sciences Project Team Representative
We are seeking an enthusiastic and motivated PK Sciences project team representative to develop and implement translational or clinical pharmacology strategies to support the pursuit of transformative new medicines through late clinical development. Our unique organizational structure enables colleagues to work seamlessly in the translational and/or clinical space, offering opportunities for development and bench-to-bedside-to-bench translation. Experience in late discovery into clinical development is preferred. The scope of the role potentially includes small molecules, biologics/therapeutic proteins, antibody drug-conjugates, radioligand therapies and/or cell therapies across major therapeutic areas in Novartis, including oncology, immunology, cardiovascular renal metabolism, neuroscience, and global health. This position drives close interdisciplinary collaboration among the PK Science disciplines, Drug Disposition (ADME, BA), Modeling & Simulation (M&S), and Operations through PK science sub-teams to achieve a holistic and integrative perspective of the ADME/clinical pharmacology properties of candidates and drugs. Collaborates effectively with broader, cross disciplinary project teams to ensure PKS strategies are well integrated into project plans and scientific discussions.
$208k - $286k
...Flagship Pioneering is looking for a Principal Scientist specializing in Machine Learning to lead AI projects that impact early-stage ventures. Ideal candidates will possess a strong background in AI/ML and hold a Master’s or PhD. Responsibilities include overseeing technical...Principal$138.6k - $257.4k
...Description SummaryWe are seeking a highly motivated and experienced scientist to lead a small group of biologists with advanced imaging... ...for patients.Job DescriptionInternal Job Title: Senior Principal Scientist/Associate DirectorPosition Location: Cambridge, MA,...PrincipalFull time$115k - $215k
...quantitative proteomics data analysis tools.Domain leadership with cross-functional drug discovery:Highly organized, solutions-oriented scientist with the ability to manage multiple priorities simultaneously while driving innovation in targeted proteomics workflows and...Principal$160k - $235k
...Sr. Scientist/Principal Scientist, Translational Research and Clinical Biomarkers (Immunology) Boston, MA Salary Band: $160,000-$235,000 Location: Downtown Boston, MA Position Summary Antares Therapeutics is seeking to add an enthusiastic and highly motivated...Principal$148.5k - $214.5k
Job title: Senior Principal Scientist Type 2 ImmunologyLocation:Cambridge, MAAbout the JobImmunology and Inflammation Therapeutic AreaWe have an exciting opportunity to join Sanofi's Translational Biology team as a Senior Principal Scientist within the Type 2 Immunology...PrincipalFull time$112.02k - $118.4k
...Principal Associate Scientist (Boston, MA) Principal Associate Scientist sought by Ascidian Therapeutics, Inc. to design, validate, execute, and interpret experiments to improve therapeutic performance of designer RNA editing molecules & contribute to characterization...Principal$175k - $225k
...follow @ScholarRock on X and on LinkedIn.Summary of Position:Scholar Rock is seeking an accomplished and highly collaborative Principal Scientist, Biomarker Development, to provide scientific leadership for biomarker strategy and execution across preclinical programs in...PrincipalFull time$160k - $224k
The Role: Generate is seeking an accomplished Principal Scientist to lead Target Binding efforts within our Protein Analytics & Biophysics (PAB) department.This individual will provide scientific and strategic leadership for protein-protein interaction, target-binding,...PrincipalShift work$168k - $252k
Job DescriptionVertex is seeking an accomplished Senior Principal Scientist with proven record of developing, testing and deploying scientific computational methods and agentic AI systems for drug discovery. In this role, you will work across modalities with emphasis on...PrincipalFull timeSummer workRemote workFlexible hours2 days per week3 days per week$146k - $236k
About Pioneering IntelligencePioneering Intelligence builds on Flagship Pioneering’s legacy of founding cutting-edge science and computational ventures, harnessing recent advances in AI, machine learning, and data to accelerate fundamental research and create a portfolio...Principal$179k - $236k
...nonclinical and clinical programs, operating as a hands-on scientific leader. We are looking for an accomplished DMPK and bioanalytical scientist with experience in PK study design, bioanalytical method development, and translational biomarker strategy. This person will...Principal$146k - $236.5k
About the Role:FL117, a venture-backed stealth AI x bio company, is seeking a Sr. Scientist / Principal Scientist, Molecular Simulations. Here you will build the physics layer of a drug development AI platform. You will characterize how binders engage their targets and...Principal$168k - $252k
...high-value opportunities across the design-make-test-analyze (DMTA) cycle and translate them into scientifically rigorous AI co-scientists that enhance compound design, knowledge synthesis, data interpretation, hypothesis generation, and decision-making. Although the...PrincipalFull timeSummer workRemote workFlexible hours2 days per week3 days per week$108.5k - $201.5k
Description:Mariana Oncology is seeking a Principal Scientist I, Medicinal Chemistry to join our Discovery Chemistry team. The successful candidate will play a key role in advancing innovative radiopharmaceutical and precision medicine programs, with a focus on peptide-...Principal$188k - $259k
About This Role Biogen is seeking a Sr. Principal Scientist, Oral Drug Product Development to provide scientific and strategic leadership for the development of small molecule oral drug products. This role leads scientific and engineering efforts supporting formulation...PrincipalFull timeTemporary workLocal area$198.9k - $269k
...range of science and engineering domains within Amazon, and you will join the team at the forefront of this research.As a Principal Applied Scientist, you will play a pivotal role in shaping the definition, vision, and development of product features from beginning to...PrincipalFlexible hours$122.25k - $176.58k
Job Title: Principal Scientist, Quantitative Systems PharmacologyLocation: Cambridge, MAAbout the job:We are an innovative global healthcare company with one purpose: to chase the miracles of science to improve people’s lives. We’re also a company where you can flourish...PrincipalFull timeInternship$108.5k - $201.5k
Job Description SummaryAs a Principal Scientist, you will lead and execute formulation development and characterization strategies for complex biologics—including monoclonal antibodies (mab’s), multispecifics, antibody-drug conjugates (ADCs), and other modalities. You will...PrincipalFull time$108.5k - $201.5k
...Description SummaryWe are seeking a highly curious, hands-on scientist to help build the next generation of opportunities for Frontier... ...setting to advance project goals.Job DescriptionInternal Job Title: Principal Scientist IPosition Location: Cambridge, MA, onsiteWe are...PrincipalFull timeTraineeship- Sanofi US Cambridge is seeking a Senior Principal Scientist in Type 2 Immunology to lead preclinical programs and translate insights into early clinical strategies across dermatology, gastroenterology, respiratory and rheumatology. You will operate at the interface of cutting...Principal
$126k - $234k
...of treatment approaches including targeted therapies, immunotherapies, CAR-T, and radioligand therapy. NIBR is seeking an in vivo scientist to join our Oncology Pharmacology team in Cambridge, MA. The successful candidate will join a dynamic, multi-disciplinary team and...PrincipalFull timeRemote work$119.7k - $222.3k
...preferably in a lead role overseeing ADME/DMPK project strategy in clinical development, or in AI strategy, to be considered for Principal Scientist II. 4+ years of experience to be considered for Senior Principal Scientist.Extensive and in-depth knowledge of...PrincipalFull time$208k - $286k
...cycles, continuously improving their performance while maintaining exploration of novel directions. We are looking for a Senior Principal Scientist to invent and build the next generation of evolutionary algorithms.In this role you will develop methods that enable...Principal$216k - $297k
...reasoning efforts on both the technical and application levels. You will be a hands-on lead for a team of talented machine learning scientists innovating on model architectures that will create best-in-class biological reasoning engines. You will be responsible for...Principal$142.5k - $256.5k
The RoleModerna is seeking an accomplished and highly motivated Principal Scientist to join the Antibody Discovery team within Therapeutics Research. Therapeutics Research generates innovative therapeutic concepts and advances them from early scientific idea through First...PrincipalPermanent employmentFull timeWork from home- ...Principal Scientist Our mission at Asimov is to advance humanity's ability to design living systems, enabling biotechnologies with outsized benefit to society. We're developing a mammalian synthetic biology platform––from cells to software––to enable the design and...Principal
- ...therapeutic platform with the potential to address significant unmet medical needs. We are seeking an accomplished and highly collaborative scientist to lead the Cellular Biology function. The ideal candidate will bring deep scientific and technical expertise in bone marrow...Principal
$121.28k - $202.13k
...success. We’re uniting science, technology, and talent to get ahead of disease together.Find out more:Our approach to R&DPrincipal Scientist (m/f/d) Genomic Technologies, Human Genetics and GenomicsThis position may be based at a GSK R&D site in UK (Stevenage), in USA (...PrincipalFull timeWork at officeLocal area$142.5k - $256.5k
The RoleModerna is seeking a highly motivated Principal Scientist, Mass Spectrometry to join the Cancer Vaccine and Bioinformatics Research (CVBR) team and support preclinical research.This role combines significant hands-on laboratory work with scientific and technical...PrincipalPermanent employmentFull timeWork from home$176.2k - $277.3k
...DescriptionBoston Pharmacokinetics, Dynamics, Metabolism and Bioanalytics - Principal ScientistOur company is a global health care leader with a... ...a dynamic, strategic thinking and collaborative Principal Scientist (director-level equivalent) to contribute to our company’s...PrincipalFull timeFor contractorsLocal areaWorldwideFlexible hours
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