Senior Python Backend Engineer
3Pillar Global
Accomplished Tech Visionary
Elevate your expertise to new heights at 3Pillar, the premier destination for trailblazing senior engineers like yourself. Picture collaborating with industry leaders and spearheading transformative projects that directly impact global clinical trial outcomes. Our mission is to revolutionize healthcare technology, and your skills are integral to achieving this ambitious goal.
Your role extends beyond writing code; you will architect scalable backend services for the BX platform and guide a team of engineers in delivering cloud-native, Python-based systems built for the demands of clinical research. Join us and spearhead the charge toward a tech future that transcends the ordinary.
You will be focused on leading the development of Python backend services running on AWS, managing PostgreSQL databases, architecting Kubernetes-based infrastructure, and ensuring seamless cloud-to-cloud integrations critical to the BX platform.
Key Responsibilities
- Facilitate effective communication with client project stakeholders regarding project status and technical recommendations.
- Lead the design and development of backend services and APIs using Python and the Pyramid framework on AWS.
- Architect and manage PostgreSQL schemas, queries, and performance optimizations for clinical-grade data.
- Build and maintain AWS infrastructure including Kubernetes (EKS), Lambda, API Gateway, and cloud-to-cloud integration patterns.
- Define backend coding standards, API design patterns, security best practices, and testing strategies.
- Mentor and guide backend engineers, driving engineering excellence across the team.
- Engage in agile software development including stand-ups, sprint planning, retrospectives, and estimation.
- Independently drive project delivery within defined architecture, demonstrating autonomy from conceptualization to deployment.
Minimum Qualifications
- Experience/expertise in the following areas specified below:
- Design and implement scalable backend services and APIs using Python
- Architect PostgreSQL databases with strong skills in schema design, query optimization, and data integrity
- Utilize AWS services: Kubernetes (EKS), Lambda, API Gateway, RDS, S3, IAM, and cloud-to-cloud integrations
- Mentor engineers, conduct code reviews, and enforce engineering standards across the team
- Deliver production systems with high reliability, observability, and security
- Must-Have Skills & Tools:
- Languages: Python, JavaScript, SQL, REST API
- OAUTH 2
- Docker
- Database: PostgreSQL (advanced — schema design, performance tuning, stored procedures)
- Cloud: AWS – Kubernetes (EKS), Lambda
- Tools: Jira, Bitbucket/GitHub, Slack/Teams
- Good to Have Skills:
- Framework: Pyramid (Python web framework)
- VsCode
- Typescript
- Snowflake
- SQL Alchemy (ORM)
- Strong understanding of SOLID principles, OOP, and clean architecture patterns.
- Familiarity with OWASP security practices.
- English proficiency.
Additional Experience Desired
- Experience with clinical or healthcare data systems (HL7, FHIR, GxP, 21 CFR Part 11).
- Knowledge of microservices and serverless architectural patterns.
- Experience with Docker, container orchestration, and modern CI/CD tooling.
- Proficiency with unit testing, integration testing, and TDD practices.
What is it like working for 3Pillar Global?
At 3Pillar, we offer a world of opportunity:
- Imagine a flexible work environment – whether it's the office, your home, or a blend of both. From interviews to onboarding, we embody a remote-first approach.
- You will be part of a global team, learning from top talent around the world and across cultures, speaking English everyday.
- We're big on your well-being – as a company, we spend a whole trimester in our annual cycle focused on wellbeing. Whether it is taking advantage of fitness offerings, mental health plans (country-dependent), or simply leveraging generous time off, we want all of our team members operating at their best.
- Our professional services model enables us to accelerate career growth and development opportunities – across projects, offerings, and industries.
- We are an equal opportunity employer. It goes without saying that we live by values like Intrinsic Dignity and Open Collaboration to create cutting-edge technology AND reinforce our commitment to diversity – globally and locally.
Join us and be a part of a global tech community! Check out our Careers page to learn more about what it's like to be part of our #oneteam!
Benefits
- Medical Insurance benefits as per company policy.
- Dental insurance as per company policy.
- Vision insurance as per company policy.
- Employer paid Disability, Life, and AD&D insurance
- Unlimited PTO
- Paid parental leave
- 401K
- Flexible work policy
- 12 Paid Holidays
- ...Senior Python Backend Engineer We are seeking a talented and experienced Senior Python Backend Engineer to join our dynamic team. This role is perfect for an individual who thrives in a fast-paced environment and is passionate about developing high-quality, scalable...SeniorRemote work
- A leading software solutions company is looking for a seasoned backend developer with expertise in Python to design and maintain cutting-edge serverless architectures. This fully remote role requires over 8 years of experience, strong skills in functional programming,...SeniorRemote jobFlexible hours
- ...Senior Python Backend Engineer Quevera is seeking a highly skilled Senior Python Backend Engineer with an active TS/SCI clearance with Polygraph to support mission-critical programs in Linthicum, Maryland. As part of the Secure the Enterprise initiative, you will help...SeniorTemporary work
- Northbeam is seeking a senior software engineer with a backend emphasis to take product problems from first principles through implementation. You’ll spend about 70% on backend and distributed systems and 20-30% on frontend, owning features across the stack when needed....SeniorRemote job
- ...Science or a related field. ~Strong Python coding skills - 7+ years. ~2+ years of... ...production LLM systems. ~Experience building backend APIs with FastAPI, async patterns, rate... ..., AWS or GCP; ~Experience in data engineering in Big Data systems including: Large-...SeniorFlexible hours
$148.03k - $222.04k
...to both our team and our customers. We are looking for a Sr Backend Python Developer to join our team. You will be responsible for planning... ...performance metrics. Provide guidance and support to other engineers. Integrate knowledge of business and functional priorities. Act...SeniorFull timeNight shiftWeekend work- ...Senior Backend Developer Work on the largest structured social graph, X / Reddit Enterprise Data APIs & Internal APIs, cloud infrastructure... ..., Amazon, and many more. What we use: Linux Python, Postgres, Redis AWS, Hetzner, Docker, Kubernetes (Openshift...SeniorRemote work
$180k - $220k
...Senior Backend Engineer (Python) Title of Role: Senior Backend Engineer (Python) Location: San Francisco, CA, On-site Company Stage of Funding: A - Administrative and Support Services Office Type: On-site Salary: $180K-$220K Company Description...SeniorWork at office- ...environments. Strong experience with asynchronous Python, APIs, and data-heavy workloads is highly... ...You'll build – data models, core backend infrastructure and services, as well as... ...that feed our proprietary AI extraction engine. You'll brainstorm – We're not looking...SeniorSummer workWork at office
- Motion Recruitment Partners LLC in Woodland Hills, California, is seeking a backend engineer for a full-time, hybrid role focused on Python, APIs, and scalable backend systems within an AI-first/enterprise SaaS context. You will design and implement high-performance services...SeniorFull time
- Zego is seeking a Software Engineer to strengthen backend systems with Python and cloud-native microservices. You’ll own complex problems, write clean, scalable code, and contribute to architectural decisions that drive reliability and performance. This role is remote...SeniorRemote jobWork at office
- ...Senior Backend Engineer (Python) Remote - United States Our mission at Oura is to empower every person to own their inner potential. Our award-winning products help our global community gain a deeper knowledge of their readiness, activity, and sleep quality by using...SeniorTemporary workWork experience placementWork at officeLocal areaRemote workFlexible hours
$210k - $220k
...Requirements: ~14 years of experience as a software engineer ~ Bachelor’s degree in a technical discipline ~4... ...Description: Provides support to the UI Team looking at backend work. Solid experience with Python required. Will support the transition to cloud...SeniorFull timeImmediate startRemote work- DaySmart Software is seeking a Senior Software Engineer to evolve our TeamUp platform. You will design, develop, and maintain core API services and backend systems using Python, Django, and FastAPI, while building Vue-based frontends for customers. This AI-first environment...SeniorRemote job
- ...Palo Alto Networks, Inc. is seeking a Senior Principal Backend Engineer for the Cortex group. You will lead backend development for Cortex XSOAR, XDR, and XSIAM, shaping data models, APIs, and scalable services in collaboration with cross-functional teams. The role...Senior
- Motion Recruitment in Pleasanton, CA seeks a senior backend engineer for a full-time hybrid role focused on Python, agentic AI, and scalable backend systems. You will contribute to high‑impact distributed architectures and AI‑driven product innovation. You will mentor others...SeniorFull time
- EPAM Systems, Inc. is seeking a Senior Java Developer with Python skills to join our team in Spain in a remote working mode. You will design, develop, and maintain scalable backend applications using Java and Python/Django across the full software lifecycle. You will work...SeniorRemote job
$165k - $215k
...APM post-launch monitoring. ~Uphold engineering excellence by conducting thorough code reviews... ...mid-level and junior engineers in async Python best practices, pydantic-ai agent design... ...~6+ years of professional backend development experience with expert-level...SeniorFull timeTemporary workWork experience placement- Role Description As a Senior Backend Engineer on the Flow Components functional team, you'll help build GitLab's Flow Registry, which provides... ...Platform. Your primary focus will be backend engineering in Python, using LangChain and LangGraph to develop secure, reliable,...SeniorFull timeRemote workFlexible hours
$160k - $260k
...remote team as well. About the role We are looking for a Senior Backend engineer passionate about building robust, scalable distributed systems... ...Expertise in Kubernetes (K8s) and Docker Proficiency in Python and Node.js for building and maintaining APIs and services...SeniorFull timeWork at officeRemote work- ...designed and constructed. If you enjoy solving "real-world" problems where code meets concrete, this is your spot. As a Senior Python Backend Engineer at AIAEC, you will be a key architect and builder of ChatAEC and our suite of AI-driven civil engineering tools. You...Senior
- Northbeam is building the world's most advanced marketing intelligence platform. We’re seeking a senior software engineer who leans backend to design scalable systems and deliver full-stack features across the stack. You’ll spend most time on backend and data processing...SeniorRemote job
$163k - $246.5k
...Dropbox. Learn more at semgrep.dev. About the role As a Backend Engineer, you'll work on our backend and infrastructure systems to... ...Our stack utilizes Typescript and React on the Frontend, Python, Flask and SQLAlchemy on the Backend, is deployed via Kubernetes...SeniorFull timeCurrently hiringLocal areaRemote workWeekend work3 days per week- ...improve society, and can demonstrate the right set of software engineering skills to effectively develop robust and scalable applications... ...Minimum 6 years of demonstrable experience building intricate backend systems Solid SQL and noSQL database experience (Postgres,...SeniorRemote jobFull time
$165k - $195k
...SITE Technologies is seeking a thoughtful and versatile Senior Backend Software Engineer to help build and evolve SITE's platform and related customer... ...maintain core backend APIs and services, primarily in Python and FastAPI ~ Translate complex product workflows into...SeniorRemote jobFull timeTemporary work- ...workflows today. We are a passionate team of engineers, physicists, and cryptographers... ...communications! Qrypt is looking for a Senior Backend Software Engineer to own the services... ..., primarily in Rust, with some C++ and Python. ~ Own significant parts of the...SeniorFull timeWork experience placementWork at office
$180k - $210k
...Millennial Software is seeking a Senior Backend Software Developer to join our collaborative... ...reliability while partnering with frontend engineers, analysts, and users. The ideal... ...in at least one backend language (e.g., Python, Java, Go, C#, Node.js) and common frameworks...SeniorFull time- ...About The RolePolymarket is looking for a backend engineer to build the systems that power how... ...individual contributor working with other senior engineers to design, implement, and... ...experience, with strong proficiency in Python or Go (preferred), or another language...Senior
- ...operators get patients the right care, at the right time, in the right setting. Role Description We’re seeking a Senior Backend Engineer with a passion for systems architecture, data modeling, and large-scale workflow orchestration . In this role, you’ll...SeniorFull timeWork at office
$96.9k - $247.9k
...built a culture that’s passionate about developing software engineers. Software doesn't build itself. People do. In fact, teams of... ...the Washington Business Journal. We’re looking for multiple Backend Python Engineers to join our growing team, and we have opportunities...Full timeImmediate start
Do you want to receive more vacancies?
Subscribe and receive similar vacancies to Senior Python Backend Engineer. Be the first to apply!
- python developer data analytics United States
- python developer internship United States
- work from home python developer United States
- python programmer United States
- python sql developer United States
- full stack / python developer (remote) United States
- freelance python developer United States
- c++-python developer United States
- python developer remote United States
- python automation engineer United States



