Senior Director, Biostatistics

Senior Director, Biostatistics

Your mission is to provide expert strategic and statistical leadership for Bicycle's clinical development portfolio. You will lead a team of biostatisticians, providing quantitative deep thinking to shape study designs, guide program strategy, and ensure the integrity of our clinical data. As a key leader in the Biometrics function, you will be instrumental in translating complex data into clear, actionable insights that drive our innovative therapies forward for patients.

Your Responsibilities

Team Leadership & Development

• You will lead, coach, and mentor your team of biostatisticians, investing in their professional growth and fostering a culture of high performance and psychological safety.
• You will set clear goals and strategic priorities for the biostatistics function, ensuring its work is directly aligned with departmental and organizational objectives.
• You will champion the Bicycle Values in all that you do, acting as a role model and embedding a culture of collaboration, accountability, and innovation within your team.

Statistical Strategy & Program Leadership

• Serve as the program-level biostatistical lead for key development assets, providing strategic input and quantitative expertise to shape the clinical development plan.
• Collaborate with senior leaders in Medical, Clinical Research, and Regulatory Affairs to address critical questions and support data-driven clinical decision-making.
• Represent the biostatistics function in all regulatory interactions, including providing statistical expertise for meetings and authoring key sections of regulatory documents.

Study Execution & Technical Oversight

• Provide senior oversight for all study-level biostatistical activities, including work conducted by vendors, to ensure the highest standards of quality and timeliness.
• Apply advanced statistical methods, including modeling and simulation, to solve challenging issues in study design, analysis, and interpretation.
• Provide expert review and approval for key statistical documents, including protocols and Statistical Analysis Plans (SAPs), ensuring they are fit for purpose.

Qualifications

• Extensive experience and a record of senior leadership in biostatistics within the biopharmaceutical industry, with a deep focus on oncology clinical trials.
• Proven experience in people management and leading high-performing technical teams.
• Demonstrated ability to develop and execute the statistical strategy for clinical development programs and translate complex data into clear, impactful insights.
• Authoritative knowledge of advanced statistical methods, regulatory guidelines (GCP), and their application to all phases of clinical development.
• Proficiency with statistical programming languages (e.g., R, SAS) and a deep understanding of simulation and modeling techniques.

Competencies & Values

• Core Expertise: You guide the statistical and quantitative strategy across multiple functions, shaping the company's approach to clinical study design and data analysis.
• Data / Insight: You provide foresight and strategic interpretation of complex clinical trial data, simulations, and statistical models to guide long-term development strategy.
• Knowledge Sharing: You represent the Biostatistics function externally and internally as a thought leader, promoting best practices and enhancing Bicycle's scientific reputation.

Job Complexity

• Task / Project Delivery: You oversee a portfolio of clinical programs, ensuring that all biostatistical strategies are aligned, resourced, and executed to meet organizational goals.
• Problem-Solving: You solve systemic, organization-wide challenges, such as defining the statistical strategy for a pivotal trial or addressing complex regulatory questions.
• Strategic Impact: You contribute directly to organizational strategy and direction by ensuring a cutting-edge, statistically robust approach is embedded across our clinical pipeline.

Independence

• Autonomy: You shape the cross-functional direction of clinical programs, participating in key strategic decisions on study design and data interpretation.
• Decision-Making: You make enterprise-level decisions on statistical strategy and methodology that have organization-wide implications for our clinical programs.
• Leadership / Mentorship: You develop future organizational leaders, providing coaching to senior statistical professionals and ensuring robust succession planning for your function.

Values & Behaviours

One Team

• Collaboration: You create alignment across multiple senior teams (Biometrics, Clinical, Medical, Regulatory), ensuring biostatistics is a seamless and strategic partner in our development engine.
• Inclusive Leadership: You embed inclusivity and collaboration into the culture, acting as a role model for how to integrate diverse scientific and quantitative perspectives.
• Mentorship / Support: You coach senior leaders and statistical experts, actively engaging in succession planning to build our future leadership pipeline.

Adventurous

• Innovation: You champion the adoption of innovative statistical methodologies and practices that have the potential to transform our approach to clinical development.
• Risk-Taking: You take calculated, high-level risks, such as using novel study designs or advanced simulation techniques, to position our programs for success.
• Change Leadership: You lead the organization confidently through major data readouts and regulatory submissions, providing clear direction and fostering enterprise-wide alignment.

Dedicated to our Mission

• Accountability: You ensure organizational priorities for your programs remain directly aligned with our core mission, holding the wider team accountable for data integrity and quality.
• Resilience: You sustain focus and determination during high-stakes challenges, providing a steadying influence through key clinical milestones and regulatory reviews.
• Inspiration: You inspire organization-wide commitment to our purpose, articulating a compelling quantitative vision that connects robust data directly to patient outcomes.

Additional Information

• Flexible working environment
• Competitive reward including annual company bonus
• Medical, dental, and vision insurance for eligible employees and their families with 100% of the premiums covered by the Company
• Health and Dependent Care Flexible Spending Accounts
• 401(k) plan with a 4% Company match and immediate vesting
• Eligibility to accrue up to 23 paid time off days per full year worked, plus the option to buy up to 5 additional days
• Employee assistance program
• Employee recognition schemes
• 10 Company holidays
• Competitive Family Leave Policy
• Eligibility for an option grant to subscribe to shares in Bicycle Therapeutics plc.

Compensation:

• Salary Range: $235,000 - $295,000

We have shared the expected recruitment base pay range for this full-time position based on the anticipated location. The actual base pay will depend on several factors unique to each candidate, including skills, qualifications, experience, and the actual location of the role. At Bicycle, base pay is just one component of the total reward package. This role is also eligible for Bicycle's discretionary annual bonus program (or sales incentive program), its comprehensive health and retirement benefit programs, and equity grants. During the hiring process, your Bicycle recruiter can share more about the Company's total reward package.

Bicycle Therapeutics is committed to building a diverse workforce that is representative of the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, color, gender, sexual orientation, age, disability status, marital status, or veteran status.