Research Scientist, Immunology and/or Musculoskeletal Biology, Levi Lab

WHY UT SOUTHWESTERN?

With over 75 years of excellence in Dallas-Fort Worth, Texas, UT Southwestern is committed to excellence, innovation, teamwork, and compassion. As a world-renowned medical and research center, we strive to provide the best possible care, resources, and benefits for our valued employees. Ranked as the number 1 hospital in Dallas-Fort Worth according to U.S. News & World Report, we invest in you with opportunities for career growth and development to align with your future goals. Our highly competitive benefits package offers healthcare, PTO and paid holidays, on-site childcare, wage, merit increases and so much more. We invite you to be a part of the UT Southwestern team where you'll discover a culture of teamwork, professionalism, and a rewarding career!

JOB SUMMARY

Plans, coordinates, directs, and participates in work of smaller research project or major unit of large research project in field of specialization for which incumbent is particularly qualified in terms of extensive training and/or experience. The Research Scientist will lead and support mechanistic and translational studies of osteosarcoma, with emphasis on tumor cell signaling, the tumor microenvironment, neural and neuroimmune regulation, angiogenesis, treatment response, and pulmonary metastasis. The position requires substantial scientific independence, rigorous experimental execution, and the ability to integrate in vitro, in vivo, imaging, and multiomic approaches. The Levi laboratory in the Division of Burn, Trauma, Acute and Critical Care Surgery in the Department of Surgery has an opening for a Research Scientist with expertise in Immunology and/ or Musculoskeletal Biology. The Levi lab’s mission is to improve the lives of people living with skin and musculoskeletal injuries and diseases through rigorous science and compassion. Current projects in the Levi laboratory are related to the molecular biology behind tissue fibrosis and the repair and regeneration process in tendon, muscle, and bone. The laboratory integrates multiomics-based approaches with investigations of musculoskeletal development, homeostasis, repair, and regeneration. The laboratory uses transgenic animal models combined with bioinformatic approaches to understand the cell‑cell interactions that occur within the stem cell niche under physiological conditions and strives to understand how these divergent signaling mechanisms may guide future therapeutic strategies to promote faithful repair of damaged tissue. The Research Scientist will work under general direction to support the long‑term research goals of the PI, perform sophisticated procedures to meet project needs by applying high‑quality research methods and will improve existing ones as needed. Job duties include: Participates in experimental design, data collection, and data analysis. Carries out routine molecular bench work combined with the use of animal models (animal handling, injections, surgeries, sample collection) as well as downstream processing (histology, immunofluorescent stain and confocal imaging, flow cytometry, cell culture, single cell and bulk RNA sequencing) under supervision of the PI. Histology, immunofluorescent stain and confocal imaging, flow cytometry, and work with cell cultures and single-cell and bulk RNA sequencing · Supervises laboratory personnel including students, technicians, and advanced degree holders in research techniques and protocols. · Develops and/or advises on the development of new approaches for achieving research goals. · Helps prepare data for, and assists with, writing/editing grants and manuscripts. · Performs other duties as assigned. The ideal candidate will have experience with flow cytometry and spectrometry. Animal experience, with particular emphasis on animal breeding, genotyping, and animal surgery is needed. Ability to utilize a variety of molecular biology techniques, including but not limited to PCR, qPCR, western blotting, RNA/DNA extraction, cloning, CRISPR/Cas9 gene editing, and next generation sequencing will be preferred. Additionally, experience with single‑cell transcriptomic analyses would be highly beneficial.

BENEFITS

UT Southwestern is proud to offer a competitive and comprehensive benefits package to eligible employees. Our benefits are designed to support your overall wellbeing, and include: PPO medical plan, available day one at no cost for full‑time employee‑only coverage 100% coverage for preventive healthcare-no copay Paid Time Off, available day one Retirement Programs through the Teacher Retirement System of Texas (TRS) Paid Parental Leave Benefit Wellness programs Tuition Reimbursement Public Service Loan Forgiveness (PSLF) Qualified Employer Learn more about these and other UTSW employee benefits!

EXPERIENCE AND EDUCATION

Required Education PhD with major course work in the field of assignment or Master's Degree with major course work in the field of assignment or Bachelor's Degree with major course work in the field of assignment Experience 5 years of research experience in the field of assignment with PhD including 2 years at the level of Senior Research Associate or its equivalent or 7 years of research experience in the field of assignment with Master's degree including 3 years at the level of Senior Research Associate or its equivalent or 9 years of research experience in the field of assignment with Bachelor's degree including 4 years Level of Senior Research Associate or its equivalent.

JOB DUTIES

Plans, organizes coordinates, directs, and personally participates in assigned scientific or medical research project. Selects or assists in selection of key research personnel. Determines specific goals or objectives to be attained. Assigns and reviews work of subordinates. Plans experimental protocols. Reviews and analyzes resulting research data. Revises techniques or approaches to work problems as indicated necessary by research data. Compiles, writes, and submits research results to supervisor. Prepares or assists in preparation of research papers, reports, and abstracts for publication as one of co‑authors. Designs, develops, or adapts equipment used in experiments or research to obtain desired results. Plans and supervises training of technicians and other laboratory personnel with respect to proper laboratory techniques, use of laboratory equipment, and safety procedures. Supervises group of employees of lower grade engaged in performance of technical and professional work, which vary from routine to complex laboratory work tasks. May confer with industrial, governmental, or other groups concerning progress or results of research project. Performs other duties as assigned.

SECURITY AND EEO STATEMENT

Security This position is security‑sensitive and subject to Texas Education Code 51.215, which authorizes UT Southwestern to obtain criminal history record information. EEO UT Southwestern Medical Center is committed to an educational and working environment that provides equal opportunity to all members of the University community. As an equal opportunity employer, UT Southwestern prohibits unlawful discrimination, including discrimination on the basis of race, color, religion, national origin, sex, sexual orientation, gender identity, gender expression, age, disability, genetic information, citizenship status, or veteran status. #J-18808-Ljbffr The University of Texas Southwestern Medical Center