Lead System Engineer
System One
Title: Lead Design Engineer
Location: Onsite, Pittsburgh, PA 15213
Type: Direct-Hire/Permanent
Hours: Standard business hours
Start: May
Overview: Join a cutting-edge lab to discover novel therapeutics that are seeking a highly motivated Lead Engineer to support the development, integration, and operation of advanced aerosol delivery, sensing, and exposure systems for human-relevant experimental platforms. This role focuses on ensuring precise, reproducible generation and delivery of airborne agents, as well as integration of instrumentation and multi-system platforms to enable controlled and standardized experimental workflows. The position will contribute to system optimization, performance validation, and operational readiness in complex laboratory environments.
Responsibilities:
- Design, prototype, and refine biomedical devices and components supporting advanced experimental system
- Develop and optimize fabrication processes to ensure consistency, quality, and scalability
- Contribute to selection and evaluation of materials, fabrication methods, and assembly workflows
- Perform testing and validation of device performance, including durability, reproducibility, and functional integrity
- Collaborate with scientific and engineering teams to align device design with experimental requirements
- Maintain documentation related to design iterations, fabrication processes, and quality control
- Troubleshoot device-related issues and implement design improvements
- Support coordination of engineering activities across multidisciplinary teams and contribute to project execution
- Contribute to preparation of technical documentation, reports, and related materials
Requirements:
- Bachelor’s degree in Biomedical Engineering, Mechanical Engineering, Electrical / System Engineering, or a related field
- Minimum of 3 years of relevant experience in device design, prototyping, or fabrication
- Experience with engineering design tools (e.g., CAD software)
- Strong problem-solving skills and attention to detail
- Ability to work effectively in multidisciplinary research and engineering environments
Preferred Qualifications
- Master’s or Ph.D. in a relevant engineering discipline
- Experience with fabrication of small-scale or precision-engineered devices, including Organs-on-Chips, injection molding, and CNC milling
- Familiarity with polymer-based materials and manufacturing processes
- Experience with iterative prototyping and design-for-manufacturing principles
- Experience working at the interface of engineering and biological systems
#M3
#LI-DS2
Ref: #558-Scientific
- ...Job Description Job Description The Systems Engineering group fosters a collaborative working environment where each member of the team has... ..., and cost-effectiveness. We are seeking a highly skilled Lead Systems Engineer to head our Xodiac vehicle programs. Job...Suggested
$142.6k - $261.5k
...data scientists, designers, and software engineers enable our clients to solve their most complex... ...Design and Development, you will lead the effective management and delivery of... ...and testing practices. Knowledgeable in system development lifecycle and technology integration...SuggestedSummer holidayFlexible hours- ...Title: Lead Design Engineer Location: Onsite, Pittsburgh, PA 15213 Type: Direct-Hire/Permanent Hours: Standard business hours... ...operation of advanced aerosol delivery, sensing, and exposure systems for human-relevant experimental platforms. This role focuses...SuggestedPermanent employmentLocal area
$125k - $167k
...Description Mission Summary: The Senior Safety Engineer supports the management of our safety... ...the execution of our safety management systems for our autonomous robotaxi organization.... ..., ISO 26262, ISO 21448/SOTIF, UL 4600) Lead cross-functional reviews of safety...SuggestedWork at office$90k - $110k
...Job Description Job Description Site Reliability Engineer About the job To ensure our operations run with exceptional precision... ...Preventative Maintenance Engineer. Responsibilities ● Leads or participates in Equipment Criticality Assessments, Critical...SuggestedWorldwide- ...solutions combine wall-climbing robots, industry-leading sensors, and an AI-powered data platform to... ...at a Glance We are hiring a Test & Reliability Engineer focused on building and scaling automated testing systems for our robotics platform. This role is responsible...Work at officeLocal areaWork from homeFlexible hours
- ...Job Description Job Description Space Systems, Launch Vehicles and Ground Ops The Systems Engineering group fosters a collaborative working environment where each member of the team has a high degree of freedom, responsibility, and expectations. We serve as the...
- ...Lead Software Engineer Pittsburgh, Pennsylvania, United States Company Description Govini transforms Defense Acquisition from an outdated manual process to a software-driven strategic advantage for the United States. Our flagship product, Ark, supports Supply...Full timeWork at office
- ...metros, monorails, and trams, to turnkey systems, services, infrastructure, signalling and... ...the industry. Every day, 80,000 colleagues lead the way to greener and smarter mobility... ...Position Could you be the full-time System Engineer in West Mifflin, PA, (Pittsburgh area)?...Full timeWorldwide
- Confidential is seeking an Audio Visual Engineer to design and document commercial audiovisual systems. This role involves creating detailed engineering packages, supporting project execution, and delivering reliable AV solutions to meet client expectations. The ideal...
- ...Hitachi Rail STS USA, Inc., headquartered in Pittsburgh, PA, seeks a Principal System RAMS Engineer to be responsible for developing, updating and maintaining a RAMS (Reliability, Availability, Maintainability and Safety) specific schedule of activities in connection...Relocation
- ...INC. Profession (Job Category): Engineering & Science Job Schedule: Full time... ...headquartered in Pittsburgh, PA, seeks a Principal System RAMS Engineer to be responsible for... ...feedback to RAMS Manager, Work Package Lead (WPL) and project team during all program...Full timeRemote workRelocation
- ...Job Title: Lead Software Engineer (Must Be US Citizen Or Green Card Holder...no OPT) Location: Pittsburgh, PA (onsite) Employment Type: Full-time, Direct Hire Pay: Commensurate with experience About the role (Must Be US Citizen Or Green Card Holder.....Full timeVisa sponsorship
- ...The Systems Engineer position is responsible for providing full cycle implementation and support of customer systems, while working across multiple company departments to ensure full client satisfaction. Under the direction of a manager or dispatcher, coordinates the...Full timeFor contractorsWork at officeLocal areaRemote workMonday to FridayShift workNight shift
- ...decisions. Job Description We are seeking an experienced Lead AI Engineer to lead our Agentic AI team as we scale our agentic offerings... ...them to do complex tasks. Experience leading agentic system development from ideation through production, including...Full timeWork at office
$130k - $160k
...safe, secure, and dynamic control that surpasses legacy systems and next-generation AI capabilities. While autonomous... ...machines—ensuring they remain safe and secure. The Lead Customer Solutions Engineer is a player-coach role — part principal technical authority...Remote work$144k - $191.25k
...team is seeking a highly motivated Staff Engineer to assume ownership of the development and... ...the program development lifecycle. Lead technical collaboration with component suppliers... ...targets and goals. Collaborate with Systems Engineers to confirm that component...Work at office- ...Fraud Hub Lead Engineer We're seeking a future team member for the role of Fraud Hub Lead Engineer to join our Corporate Engineering team... ...solutions, and delivering secure, resilient, and scalable systems. As part of Corporate Engineering, you will lead the engineering...
$57.1k - $154.3k
...Lead Database Engineer Category: Software Development/ Engineering Main location: United States, Texas, Dallas Alternate Location... ...Skills: Banking Database Administration Database Mgmt Systems DBMS Oracle SQL What you can expect from us:...Permanent employmentFull timeLocal area- ...metros, monorails, and trams, to turnkey systems, services, infrastructure, signalling... ...Every day, more than 80 000 colleagues lead the way to greener and smarter mobility... ...help you succeed and grow in this role: Engineering degree or diploma in Electronics, Electrical...Full timeWorldwide
$144k - $192k
...Mission Summary: We are looking for a Machine Learning Systems Engineer to join our ML Acceleration team. In this role, you will be responsible for the core systems that enable our researchers to train frontier models at scale, focusing obsessively on speed, cost...Work at officeRemote work- ...territories. Essential Responsibilities: Application Engineering responsibility for the Power Conversion General Industrial,... ...technical solutions for large Medium Voltage Variable Frequency Drive Systems up to 80MW, large Static Frequency Converters of 100MVA+,...Work at office
- ...and empowering the people who make water work every day. As a leading water technology company with 23,000 employees operating in over... ...USA LLC's Pittsburgh, PA, office seeks a Sr. Lead Application Engineer (Engineer-III). This is a hybrid office-based/work-from-home position...Work at officeRemote workWork from home2 days per week
- ...Senior Lead Engineer The primary function of the Senior Lead Engineer is to provide technical assistance and expertise for the DES Networking... ...Responsibilities Provide technical assistance for our systems engineers and technicians Develop implementation standards...Full timeWork at office
$100.22k - $111.18k
...Basic Qualifications Requires a Bachelor's degree in Systems Engineering, or a related Science, Engineering, Technology or Mathematics field... ...typically work in the following areas: Participate/Lead customer requirements analysis, develop system requirements...For subcontractorSecond jobWork at officeFlexible hours- ALSTOM Gruppe is looking for a full-time System Engineer based in West Mifflin, PA. In this role, you will leverage your traction system expertise... ...transport, you will guide the engineering studies and lead technical discussions to meet performance targets. A degree in...Full time
$103.71k - $138.28k
...requiring the selected candidate to both lead and participate in multiple team environments... ...independent efforts to all aspects of system integration including design, analysis,... ...and experience in system architecture and engineering disciplines. Specific technical knowledge...Full timeTemporary workRemote work- Career Opportunities with Thermo Systems LLC Careers At Thermo Systems LLC Current job opportunities... .... Our diverse leadership and dedicated engineering team are committed to excellence and... ...Works on control system projects; leads in hardware and software design,...Full timeCasual workWork at officeNight shift
- A global automation solutions provider in Allegheny County is seeking a Control System Engineer. This role involves leading hardware and software design, and it requires 2+ years of relevant experience along with a degree in engineering. The company values integrity, teamwork...Casual work
$97k - $143k
Eaton’s ES AMER ARS division is currently seeking a Lead Mechanical Design Engineer. This role is based at our Moon Township, PA facility and offers... ...concept ideation, design, testing of the components plus systems as well as product qualification for performance,...H1bLocal areaRelocationVisa sponsorship
Do you want to receive more vacancies?
Subscribe and receive similar vacancies to Lead System Engineer. Be the first to apply!
- lead engineer Pittsburgh, PA
- lead operating engineer Pittsburgh, PA
- systems engineer Pittsburgh, PA
- senior linux systems engineer Pittsburgh, PA
- healthcare systems engineer Pittsburgh, PA
- senior staff systems engineer Pittsburgh, PA
- advanced systems engineer Pittsburgh, PA
- senior windows systems engineer Pittsburgh, PA
- computer system validation engineer Pittsburgh, PA
- application system engineer Pittsburgh, PA



