Researcher 3-Medical Oncology

Job Title: Researcher 3-Medical Oncology Department: Medicine | IM Screen reader users may encounter difficulty with this site. For assistance with applying, please contact View email address on click.appcast.io. If you have questions while submitting an application, please review these frequently asked questions. Current Employees and Students: If you are currently employed or enrolled as a student at The Ohio State University, please log in to Workday to use the internal application process. Welcome to The Ohio State University's career site. We invite you to apply to positions of interest. In order to ensure your application is complete, you must complete the following: Ensure you have all necessary documents available when starting the application process. You can review the additional job description section on postings for documents that may be required. Prior to submitting your application, please review and update (if necessary) the information in your candidate profile as it will transfer to your application. Researcher responsible for performing experiments and managing projects in a clinical/translational lung cancer research lab. Planned projects are translationally important from clinical perspective and will employ cutting edge laboratory and analytical techniques. This role will focus on tumor signaling and interactions with the immune microenvironment in lung tumors that have loss of the LKB1 tumor suppressor, with goals of gaining mechanistic insight into the important clinical question of why these tumors are resistant to immunotherapy treatments, and identification and testing of candidate pathways that could be targeted to enhance immune sensitivity. Using in vitro (tumor cell lines, and a T-cell co-culture system) and in vivo model systems (murine cell lines from an LKB1 deficient GEMM that can be used for immunocompetent allograft experiments, as well as the GEMM model itself), to test hypotheses on pathways responsible for immune resistance. Conduct cutting edge high throughput experiments with functional genomics screens (e.g. CRISPRi based screens), proteomics and phosphoproteomics, single cell RNAseq, to help dissect out the mechanisms that may be responsible for these effects, which can both strengthen conclusions from hypothesis based mechanistic studies, and also can be used to gain novel insights and identify new hypotheses. Results from preclinical work will be integrated with analyses from existing multi-omic data, and also access to clinical trial specimens and or OSU clinical cohorts to test ideas in specimens from lung cancer patients. MINIMUM REQUIRED QUALIFICATIONS Master's Degree in Biological Sciences or relevant field, or equivalent experience required; 5 years of relevant experience required with Bachelor's Degree, or 3 years of relevant experience required with Master's Degree. A background in cancer biology and or immunology is a plus. Function Research and Scholarship Sub Function: Research Career Band: Individual Contributor - Specialized Career Level: S3 Additional Information The Ohio State University is a dynamic community of diverse resources, where opportunity thrives and where individuals transform themselves and the world. The Ohio State University is one of the nation's largest and most comprehensive public universities and a top employer in Ohio. As one of only 57 designated comprehensive cancer centers in the nation, The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute is dedicated to the creation of knowledge in laboratory, clinical and population-based cancer research. We apply those discoveries to develop more effective approaches to cancer prevention, diagnosis, and therapies - providing tomorrow’s standard of care today. A Cancer-Free World Begins Here. The OSUCCC - James is the only cancer program in the United States that features a National Cancer Institute (NCI)-designated comprehensive cancer center aligned with a nationally ranked academic medical center and a freestanding cancer hospital on the campus of one of the nation's largest public universities. The OSUCCC - James is the only cancer program in the United States that features a National Cancer Institute (NCI)-designated comprehensive cancer center aligned with a nationally ranked academic medical center and a freestanding cancer hospital on the campus of one of the nation's largest public universities. Location Biomedical Research Tower (0112) Position Type Regular Scheduled Hours: 40 Shift: First Shift Benefits Ohio State benefits give you options to take care of what matters most to you - and opportunities to make adjustments as your life and needs change, including: Medical, dental and vision coverage, with Ohio State paying a significant portion of the cost. Paid time off, including sick and vacation time and 11 holidays. State retirement plan or an alternative retirement plan, both with generous employer contributions. Additional Information & Promotion As Buckeyes, we accomplish more together. No matter your role, you’ll be part of creating what people need now: pathways to education, research and health care. Working at Ohio State means you’re part of a team with a strong sense of community and an unwavering commitment to excellence - and, of course, incomparable Buckeye spirit. We bring out the best in people, help each other succeed and learn together. By joining Ohio State, you become part of a top-20 public university with one of America’s leading academic health centers. We’re a team of dedicated colleagues with access to boundless resources that support you. Review the Frequently Asked Questions for details on using Workday and submitting your application. #J-18808-Ljbffr Ohio State University