Post Doctoral Scientist - AAV Gene Therapy/Extracellular Vesicles/Translational Research

Overview:Dr. Nizar Saad’s lab is seeking a postdoctoral scientist to join a translational research program advancing RNA-based and genome-editing therapies for rare genetic diseases. The lab develops RNA-, and CRISPR-based approaches for laminopathies and muscular dystrophies, using viral and non-viral delivery platforms (i.e., AAV and extracellular vesicles (EVs)). The lab also leads EV-based biomarker discovery efforts in muscular dystrophies. This position will require experience in EV and/or AAV isolation, purification, and characterization, -omics workflows, mouse work, including dosing and tissue collection. Experience in EV and/or AAV engineering is desired. Experience in cardiovascular or skeletal muscle biology is preferred. Additional details: NIH-funded grant and Saad Lab page .Job Description Summary:Conducts research, designs experiments, analyzes data, and presents findings under the mentorship of an established RI principal investigator or Senior Research Scientists. Appointment is a maximum of 7 years in length.Job Description:Essential Functions:Designs experiments, develops protocols, and conducts research under the guidance of a faculty mentor.Assists in the training and supervision of technical support staff in performing specific techniques essential to carrying out the research program.Records and analyzes data generated by the research study. Assists in the development of hypotheses for further investigation from the results of the studies performed.Assists with the preparation of scientific and technical papers for publication in peer-reviewed journals. Presents findings at local and national research forums.Collaborates with other ongoing research efforts either at NCH or at The Ohio State University.Works toward research independence, preparing to submit proposals to and obtain funding from external granting agencies.Education Requirement:PhD or equivalent degree in relevant field of science, required.Licensure Requirement:(not specified)Certifications:(not specified)Skills:Effective interpersonal skills required in interactions with scientists, physicians, and laboratory colleagues.Excellent laboratory technical skills.Excellent computer skills.Skills in qualitative and quantitative research methods.Ability to proactively manage and drive projects.Experience:Research experience from PhD program, required.Physical Requirements:OCCASIONALLY: Bend/twist, Climb stairs/ladder, Lifting / Carrying: 11-20 lbsFREQUENTLY: Lifting / Carrying: 0-10 lbs, Standing, WalkingCONTINUOUSLY: Audible speech, Color vision, Computer skills, Decision Making, Depth perception, Flexing/extending of neck, Hand use: grasping, gripping, turning, Hearing acuity, Interpreting Data, Peripheral vision, Problem solving, Reaching above shoulder, Repetitive hand/arm use, Seeing – Far/near, Sitting, Squat/kneelAdditional Physical Requirements performed but not listed above:Pressure in this position will vary depending on the workload. The workload will be heavy but manageable most of the time. Pressure may arise in the face of deadlines associated research and manuscript writing."The above list of duties is intended to describe the general nature and level of work performed by individuals assigned to this classification. It is not to be construed as an exhaustive list of duties performed by the individuals so classified, nor is it intended to limit or modify the right of any supervisor to assign, direct, and control the work of employees under their supervision. EOE M/F/Disability/Vet" #J-18808-Ljbffr Nationwide-Children