Director, Human Resources Business Partner

Job Description Director, HR Business Partner We are seeking a strategic, influential, and agile HR Business Partner Director to lead talent strategies for key G&A functions at Vertex. This Director will play a critical role in achieving the vision of enhancing leadership, driving innovation, enabling top‑tier execution, and integrating technology to achieve superior performance across a diverse development pipeline. This role will serve as a trusted advisor to G&A leaders and their teams, shaping organizational design, culture, and workforce strategies that enable innovation, execution and long‑term success. Reporting to the Lead HRBP for the G&A Functions, this individual will sit on functional leadership teams and play a critical role in driving enterprise‑wide HR initiatives and change leadership, enabling organizational effectiveness across clinical development functions. This role shapes and executes talent strategies that strengthen leadership, enable excellence, and supports Vertex’s mission to bring transformative therapies to patients. Key Responsibilities Acts as a strategic advisor and coach to senior leaders, influencing business and talent decisions through deep understanding of the operating environment, enterprise priorities, and external trends. Uses advanced data, analytics, and external insight to identify emerging workforce and capability trends; translates complexity into clear, compelling narratives that inform decision‑making, challenge assumptions, and drive action. Architects and leads integrated talent and organizational strategies that proactively address future capability needs, leadership gaps, and operating model evolution. Advises leaders on complex organization design, workforce transformation, and change leadership initiatives to enable agility, scale, and sustained performance. Shapes and executes enterprise‑aligned talent strategies to attract, develop, and retain critical skills and diverse leadership pipelines at all levels. Leads strategic workforce planning to align near‑ and long‑term talent supply with business strategy, including capability forecasting, succession planning, and scenario planning. Partners with HR Centers of Excellence (Total Rewards, Talent Acquisition, Talent Management, Strategic People Analytics, Employee Services & Global Operations) to deliver cohesive, high‑impact solutions and elevate the overall employee experience. Oversees and evolves core people processes (e.g., performance, talent reviews, compensation planning) to ensure they drive accountability, growth, and business outcomes—not just compliance. Partners with Talent Acquisition to shape forward‑looking hiring strategies aligned to critical capability builds, with a strong focus on diverse talent, pivotal roles, and board‑approved hires. Knowledge and Skills Proven ability to design and activate enterprise‑level HR and talent strategies that drive measurable business impact. Expert capability in strategic workforce planning, from insight generation and scenario modeling through execution. Deep expertise in talent management, succession planning, leadership development, and career architecture. Demonstrated leadership in large‑scale organizational change, culture evolution, and enterprise transformation initiatives. Advanced understanding of leadership effectiveness, employee relations, inclusive talent practices, and the application of workforce analytics to business decisions. Education and Experience Bachelor's degree in human resources or related, relevant discipline. 10 years of progressive HR experience or the equivalent combination of education and experience. Pay Range $187,200 - $280,800 Disclosure Statement The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job‑related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market‑leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week‑long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation Hybrid‑Eligible or On‑Site Eligible Flex Eligibility Status Hybrid: work remotely up to two days per week; or select. On‑Site: work five days per week on‑site with ad hoc flexibility. Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non‑discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E‑Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at View email address on click.appcast.io. #J-18808-Ljbffr