Principal Scientist - RGM Chemistry

We are looking for a visionary Principal Scientist – RGM Chemistry to lead the discovery, development, and optimization of antibody-oligonucleotide conjugation technologies that power next-generation targeted therapeutics. Sitting at the intersection of bioconjugation chemistry, RNA science, and process innovation, you will set scientific strategy, guide a multidisciplinary team, and translate ground breaking concepts into scalable solutions that advance our therapeutic pipeline. Your deep expertise, collaborative attitude, and passion for mentoring will drive breakthrough medicines from bench to preclinical validation and beyond.

In this role, a typical day might include the following:
- Designing and completing experiments to refine linker chemistry, payload stability, and delivery efficiency for antibody-oligo conjugates
- Analyzing conjugates with HPLC, LC-MS, and bioassays to ensure purity, identity, and functional potency
- Leading project stand-ups, mentoring scientists and research associates, and troubleshooting technical challenges in real time
- Partnering with Process Development and Manufacturing to scale promising conjugation methods for preclinical supply
- Scouting and evaluating emerging bioconjugation or RNA delivery technologies, then proposing data-driven innovation projects
- Presenting program updates and strategic recommendations to senior R&D leadership and cross-functional partners

This job might be for you if you:
- Thrive on pushing the boundaries of antibody and oligonucleotide conjugation science
- Enjoy mentoring and developing talent in a collaborative, fast-paced research environment
- Translate sophisticated data into clear, actionable insights and strategic plans
- Demonstrate a strong record of innovation, publications, and/or patents in bioconjugation or RNA therapeutics
- Excel at balancing deep scientific rigor with pragmatic process development and scale-up considerations
- Are motivated by cross-functional collaboration that accelerates breakthrough medicines to the clinic

In order to be considered for this role, you must have:
- A Ph. D. in Chemistry, Biochemistry, Molecular Biology, or related field with 5+ years of postdoctoral or industry experience in antibody/oligonucleotide conjugation
- Validated expertise in bioconjugation, oligonucleotide therapeutics, and advanced analytical techniques (HPLC, LC-MS, bioassays)
- Proven leadership of multidisciplinary teams and successful track record in advancing therapeutic candidates toward preclinical or clinical development

Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We have an inclusive culture that provides comprehensive benefits, which vary by location. In the U.S., benefits may include health and wellness programs (including medical, dental, vision, life, and disability insurance), fitness centers, 401(k) company match, family support benefits, equity awards, annual bonuses, paid time off, and paid leaves (e.g., military and parental leave) for eligible employees at all levels! For additional information about Regeneron benefits in the US, please visit For other countries’ specific benefits, please speak to your recruiter.
Please be advised that at Regeneron, we believe we are most successful and work best when we are together. For that reason, many of Regeneron’s roles are required to be performed on-site. Please speak with your recruiter and hiring manager for more information about Regeneron’s on-site policy and expectations for your role and your location.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. The Company will also provide reasonable accommodation to the known disabilities or chronic illnesses of an otherwise qualified applicant for employment, unless the accommodation would impose undue hardship on the operation of the Company's business.

For roles in which the hired candidate will be working in the U.S., the salary ranges provided are shown in accordance with U.S. law and apply to U.S.-based positions. For roles which will be based in Japan and/or Canada, the salary ranges are shown in accordance with the applicable local law and currency. If you are outside the U.S, Japan or Canada, please speak with your recruiter about salaries and benefits in your location.

Please note that certain background checks will form part of the recruitment process. Background checks will be conducted in accordance with the law of the country where the position is based, including the type of background checks conducted. The purpose of carrying out such checks is for Regeneron to verify certain information regarding a candidate prior to the commencement of employment such as identity, right to work, educational qualifications etc.

Salary Range (annually)