Principal Software Engineer

Responsibilities

• Own the architecture, implementation, and delivery of major initiatives across cloud infrastructure, workflow platforms, and data platforms.
• Lead architecture and design reviews and influence technical decisions across the engineering team.
• Mentor mid-level engineers through code reviews, design documents, and pairing.
• Build and improve AI-coding tooling, including agent-driven software development tools.
• Partner with the team lead on roadmap, prioritization, and complex technical decisions.
• Collaborate with bioinformaticians, scientists, and R&D engineers to translate needs into platform capabilities.
• Ship production software for internal or external end users and own multi-quarter technical initiatives.

Requirements

• 10+ years of professional software engineering experience across a range of systems and problem types.
• Production experience designing for a major cloud platform, with AWS preferred or GCP/Azure equivalent.
• Production experience with Kubernetes or an equivalent container orchestration platform, including cluster design, scheduling, networking, and workload patterns.
• Production experience with Terraform or an equivalent infrastructure-as-code tool, including shared modules and multi-environment deployments.
• Strong proficiency in at least one general-purpose programming language such as Python, Go, or Java.
• Experience shipping end-user software and understanding product requirements, user feedback, and competing priorities.
• Previous engineering team leadership and mentorship of junior engineers.
• Experience working in fast-moving, startup-like environments and delivering quickly.
• Familiarity with AWS, Kubernetes, Python, Go, Groovy, Terraform, Helm, Nextflow, WDL, Django, and React.
• Interest in AI-native development and building tooling that improves engineering productivity.
• Preferred experience includes scientific or bioinformatics computing, LIMS or laboratory data systems, workflow orchestration, ETL or data pipelines, and HPC or batch-compute platforms.

Benefits

• Competitive base salary and benefits.
• Annual performance incentive bonus and long-term equity awards.
• Comprehensive medical, dental, vision, life, and disability benefits.
• 401(k) with company match, paid time off, company holidays, commuter benefits, wellness and work-life benefits, and referral program.
• Eligible employees and immediate family members receive free testing and fertility care benefits.
• South San Francisco, California is preferred; remote work is optional.
• Full-time position.