Senior Manager, Commercial Technology & Digital Solutions

Arrowhead Pharmaceuticals, Inc. (Nasdaq ARWR) is a commercial stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.

Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.

Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.

The Position

Arrowhead Pharmaceuticals is seeking a highly motivated Senior Manager to lead the execution, optimization, and continuous improvement of the technology platforms, analytics, reporting, and digital capabilities that enable our Commercial organization.

Working in close partnership with the Director of Commercial Technology and business owners across Commercial, Marketing, Medical Affairs, Pricing & Market Access, and Trade & Distribution, this individual will translate business requirements into scalable technology solutions that improve efficiency, enhance decision-making, and support Arrowhead's rapidly expanding commercial organization.

This role combines hands-on platform ownership with project leadership, vendor management, analytics development, and AI-enabled process improvement. The successful candidate will help improve Arrowhead's commercial technology ecosystem while supporting U.S. operations, future product launches, and international expansion.

This is an exciting opportunity to play a key role in shaping the future of Commercial Technology at Arrowhead by helping scale systems, analytics, AI capabilities, and digital solutions that support the company's continued growth and commercialization efforts.

This role is based in Pasadena, California, with an expectation to be in office 5 days a week.

Responsibilities

Commercial Technology Leadership

• Drive the day-to-day administration, enhancement, optimization, and operational support of ZS ZAIDYN, partnering with business owners to evaluate needs, prioritize enhancements, resolve issues, and continuously improve platform capabilities.
• Manage platform configuration, releases, testing, integrations, and production support across CRM, Specialty Pharmacy, MMIT, Marketing Cloud, and other commercial data sources.
• Own Master Data Management (MDM) processes within ZAIDYN, ensuring accurate and consistent customer data across commercial applications and reporting.
• Provide secondary administration and operational support for Veeva Commercial CRM, PromoMats, and MedComms, including interface monitoring, release management, testing, and issue resolution.
• Translate business requirements into scalable technology solutions by partnering closely with business owners, IT teams, and external vendors.

Analytics, Reporting & Business Intelligence

• Develop and maintain Power BI dashboards, reports, and self-service analytics that improve business decision-making and reduce dependence on external consulting partners.
• Ensure the delivery of reliable, high-quality commercial data and reporting that supports operational and executive decision-making.
• Continuously improve reporting capabilities, data quality, and analytics processes to enhance the user experience and business insights.

AI, Digital Transformation & Operational Excellence

• Partner with the Executive Director of AI & Enterprise Data Management to evaluate, pilot, and implement AI-enabled solutions, automation, and data strategies that improve efficiency and business outcomes.
• Drive adoption of new technologies by partnering with business stakeholders, promoting best practices, supporting training, and ensuring successful implementation.
• Continuously evaluate opportunities to simplify processes, strengthen internal capabilities, optimize vendor services, and reduce total cost of ownership.

Project Delivery & Business Partnership

• Lead cross-functional technology initiatives, coordinating project plans, resources, risks, testing, vendor activities, and stakeholder communications.
• Coordinate commercial technology readiness for international expansion, future product launches, and enhancements supporting the continued growth of the U.S. commercial organization.
• Build trusted relationships with Commercial, Marketing, Medical Affairs, Pricing & Market Access, and Trade & Distribution teams by delivering responsive, reliable technology solutions.

Vendor & Financial Management

• Manage technology vendors, consultants, contracts, budgets, and service performance.
• Identify opportunities to transition appropriate capabilities in-house while maintaining high-quality support and improving operational efficiency.
• Support annual budget planning, forecasting, and ongoing cost management for commercial technology platforms and services.

Requirements

• Bachelor’s degree in Computer Science, Information Systems, Life Sciences, Engineering, or a related field.
• 8+ years of experience supporting commercial technology, commercial operations, analytics, or business systems within the biotechnology, pharmaceutical, or life sciences industry.
• Strong Power BI reporting and dashboard development experience.
• Experience managing technology vendors, budgets, and cross-functional projects.
• Knowledge of AI, automation, and digital technologies supporting commercial organizations.
• Excellent communication, project management, and relationship-building skills.
• Demonstrated ability to independently drive execution while collaborating effectively with leadership and business owners in a fast-paced, growing organization.

Preferred

• Experience with ZS ZAIDYN or comparable commercial intelligence platforms preferred.
• Experience supporting Veeva Commercial CRM, PromoMats, and MedComms.

California pay range

$160,000—$185,000 USD

Arrowhead provides competitive salaries and an excellent benefit package.

Candidates must have current, valid authorization to work in the country where this role is located.

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