Research Associate - In Vivo Biology

6‑month contract-to-hire role, with the potential to convert to full-time based on performance and business needs Help invent the future of lipid metabolism-based therapies for cancer and beyond Lime Therapeutics is a venture-backed biotech startup pioneering therapies that target lipid-metabolic pathways in cancer, metabolic, and neurodegenerative diseases. We are advancing novel therapeutic concepts toward IND-enabling studies and clinical development. We are seeking a highly motivated Research Associate – In Vivo Biology to join our growing biology team and advance our oncology drug development programs. You will work closely with experienced scientists to execute preclinical studies, evaluate novel therapeutic candidates, and generate high-quality data that directly informs our drug development decisions. This hands‑on role is ideal for an early-career scientist who is passionate about experimental biology, eager to build new technical skills, and excited to make a meaningful contribution at an early‑stage biotech company. What You’ll Do Research Associate – In Vivo Biology 6‑month contract-to-hire role, with the potential to convert to full-time based on performance and business needs Help invent the future of lipid metabolism-based therapies for cancer and beyond Lime Therapeutics is a venture-backed biotech startup pioneering therapies that target lipid-metabolic pathways in cancer, metabolic, and neurodegenerative diseases. We are advancing novel therapeutic concepts toward IND-enabling studies and clinical development. We are seeking a highly motivated Research Associate – In Vivo Biology to join our growing biology team and advance our oncology drug development programs. You will work closely with experienced scientists to execute preclinical studies, evaluate novel therapeutic candidates, and generate high-quality data that directly informs our drug development decisions. This hands‑on role is ideal for an early-career scientist who is passionate about experimental biology, eager to build new technical skills, and excited to make a meaningful contribution at an early‑stage biotech company. Preclinical Oncology Studies: Conduct pivotal studies in relevant cancer models to evaluate the efficacy and tolerability of novel therapeutic candidates. Animal Handling and Dosing: Perform routine mouse handling, restraint, and compound administration by oral gavage and intraperitoneal (IP), subcutaneous (SC), and intravenous (IV) injection. Tissue Collection and Processing: Collect and process tissues for downstream molecular, biochemical, histological, and flow cytometry-based analyses. In Vitro Biology: Establish and maintain mammalian cell cultures, including cancer cell lines, primary cells, and organoids, and support cell-based assays and molecular biology experiments. Data Integrity and Analysis: Keep accurate experimental records, analyze study data in GraphPad Prism and Excel, and clearly communicate results to the scientific team. Operational Excellence: Prepare experimental materials, maintain lab equipment and supplies, and ensure compliance with IACUC-approved protocols and lab safety standards. Collaboration and Flexibility: Work collaboratively in a fast‑paced startup, adapt to evolving research priorities, and support time‑sensitive experiments, including occasional evening or weekend work as animal study schedules require. What We’re Looking For Education and Experience: BS or MS in Biology or a related field, with hands‑on rodent in vivo experience and exposure to molecular assays in an academic, biotech, pharmaceutical, or CRO setting. In Vivo Skills: Demonstrated proficiency in mouse handling, restraint, and dosing, with working knowledge of IACUC protocols and animal welfare standards. Mammalian Cell Culture: Strong aseptic technique and experience maintaining cancer cell lines and preparing cells for in vivo implantation. Attention to Detail: The discipline to follow protocols precisely and manage multiple concurrent studies. Eagerness to Learn: A drive to master new techniques and grow your skillset as our programs advance. High Agency: A self‑starter who takes ownership and thrives in a high‑accountability environment. Why Join Lime Real Impact: Your work will shape first‑in‑class therapeutics for patients with high unmet need. Founder Access: Work directly with company leadership and world‑class advisors. Growth Path: Opportunity to build and eventually lead scientific teams as Lime expands. Mission‑Driven Culture: High ownership, strategic focus, and fast execution. Compensation and Location This is a fully in‑person, hourly contract role paying $35–50/hour, commensurate with skills and experience. Lime is headquartered at the Ford Center Incubator, a vibrant hub for early‑stage life science companies at The Rockefeller University on Manhattan’s Upper East Side. Start Date: January 2027. We are actively interviewing and aim to fill this role as soon as possible. Lime Therapeutics is an equal opportunity employer. #J-18808-Ljbffr Lime Therapeutics, Inc.