Postdoctoral Scientist

Position Overview Postdoctoral scientist (Global PKPD) developing Quantitative Systems Pharmacology (QSP) models; collaborate with cross-functional teams to develop and apply AI-powered QSP models integrating biology, pharmacology, and preclinical/clinical data. Primary Responsibilities Conduct literature, regulatory, and database searches to compile preclinical/clinical data for model design and parameterization. Design and implement ODE-based QSP model structures capturing drug PK, target/receptor biology, and cellular/physiological dynamics. Perform parameter estimation, simulations, and model analysis to support timely drug discovery/development decisions. Use validated models to generate insights for dosing strategies, risk stratification, and translational/clinical questions. Communicate results to technical and non-technical audiences; collaborate cross-functionally. Maintain documentation; present at scientific conferences; author peer-reviewed articles. Basic Qualifications / Required PhD in quantitative pharmacology, systems biology, biomedical engineering, applied mathematics, or related field. Experience developing QSP/mechanistic PKPD or ODE-based biological system models. Experience developing virtual patient populations. Proficiency in R, Matlab/Simbiology, Python, NONMEM, Monolix, or related modeling software. Experience with parameter estimation and sensitivity analysis. Authorized to work in the United States full-time; Lilly does not sponsor visas/work authorization. Preferred Skills Knowledge of T cell engager bispecifics and immunology; PK/PD and drug discovery/development. Interest in AI/ML integration; strong problem-solving, organization, communication; strong publication record. Additional Information / Benefits Fixed-term 2 years (potential to extend to 3 years). Anticipated wage: $58,000–$123,200; full-time roles may be eligible for bonus and comprehensive benefits (e.g., 401(k), medical/dental/vision, life insurance, time off, well-being). #J-18808-Ljbffr