Principal Scientist - PKDM, Modeling and Simulation

Principal Scientist-PKDM, Modeling and Simulation What You Will Do Contribute to Amgen’s drug discovery and development portfolio with a focus on understanding pharmacokinetics (PK) and pharmacodynamics (PD) for small and large molecule drug candidates across therapeutic areas. Support PK/PD-related and mathematical modeling activities in the PKDM space through target/compound evaluation, preclinical study design, exposure-response investigations, translational strategies, and influencing clinical study design. Key Responsibilities Devise and implement quantitative analyses and strategies for drug development decision-making using mechanistic and translational modeling Collaborate with PKDM and multi-disciplinary teams to generate knowledge that informs quantitative strategies Build hands-on fit-for-purpose models (PK-PD, QSP, PBPK) using specialized modeling tools; apply AI/ML to modernize PK-PD modeling Document and archive data analyses, models, presentations, and reports Summarize findings and communicate conclusions to project and cross-functional teams Build collaborations with peers and stakeholders (e.g., chemistry, biology, toxicology, biomarkers, protein scientists) Basic Qualifications PhD OR PharmD OR MD with 2 years applying quantitative PK/PD principles; or Master’s with 5 years; or Bachelor’s with 7 years. Preferred Qualifications/Skills PhD in relevant fields with 2+ years in drug discovery/development Systems modeling/simulation track record for strategic decisions Proficiency with mechanistic modeling approaches (e.g., differential equations, nonlinear mixed effects, stochastic/agent-based) Hands-on experience with tools/programming (e.g., R, Simbiology, MATLAB, R, C) Critical thinking and ability to communicate across disciplines; self-driven and flexible. Application Instructions Apply via careers.amgen.com. No application deadline; applications accepted until a sufficient number are received or a candidate is selected. #J-18808-Ljbffr Scorpion Therapeutics