ADC Development: Organic and Conjugation Chemist

Senior Scientist - Protein Engineering (ADC Development: Organic & Conjugation Chemist) We are seeking a highly motivated organic chemist to join the hybrid Modality Group in the Protein Engineering Department at Amgen located in Thousand Oakes, CA. The role involves working at the interface of synthetic chemistry, biochemistry, and chemical biology to develop antibody‑drug conjugates (ADCs) and novel modalities. Responsibilities Design, synthesis, purification, and characterization of novel organic linkers, peptides, and payloads for antibody drug conjugates. Design, synthesis, purification, and characterization of antibody drug conjugates for therapeutic discovery. Review, analyze, and interpret scientific data and results; provide regular updates, documentation, and communication on project results. Basic Qualifications Doctorate degree specializing in organic chemistry, biochemistry, chemical biology, or medicinal chemistry. Or Master’s degree and 3 years of laboratory experience. Or Bachelor’s degree and 5 years of laboratory experience. Preferred Qualifications Postdoctoral or 2+ years of synthetic chemistry experience. Experience in the synthesis and purification of ADC linker and payloads. Experience in bioconjugation processes. Experience with peptide synthesis and purification. Robust understanding of structural determination using NMR and MS techniques and proficiency with chromatography methods (HPLC, RP HPLC, ion exchange, size exclusion). Demonstrated good laboratory practices, with particular attention to safety. Strong written and verbal communication skills. Ability to work comfortably within a large team of scientists and engineers from diverse backgrounds. Benefits Full support and career‑development resources to expand your skills, enhance your expertise, and maximize your potential along your career journey. A diverse and inclusive community where teammates are empowered to bring ideas to the table and act. Equal Opportunity Statement Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status. We will ensure that individuals with disabilities are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request an accommodation. #J-18808-Ljbffr BioSpace