Senior Scientist, Delivery Biology-Tissue Lead

Overview The Research Department at Alnylam is seeking a highly motivated Sr. Scientist in Delivery Biology to support and advance targeted delivery strategies for oligonucleotides. This role will focus on discovering delivery solutions in priority tissue/cell types with compelling therapeutic targets. The successful candidate will have experience working on multiple tissue/cell types, and can apply to new tissues of interest. The focus will be on solving delivery for therapeutic targets of interest that advance as programs in clinical development. The individual will need excellent collaboration and communication skills, connecting interdisciplinary team members from medicinal chemistry, core delivery technology group and targets team. Expertise in oligonucleotide conjugate delivery is essential. This is a lab-based role at our Cambridge site. Key Responsibilities Develop and apply assays and experimental strategies to enable tissue specific delivery of oligonucleotides conjugates Design, execute, and interpret in vitro and ex vivo assaysto evaluate delivery efficiency and biological outcomes Collaborate extensively with crossfunctional partners focused on expanding targeted delivery into new cell types and tissues. Transparently communicate data, conclusions, and experimental rationale to team members and leadership Mentor and support the scientific development of junior scientists or research associates Qualifications PhD in Cell Biology, Molecular Biology, Immunology, Biochemistry or related field. 2-3 years of experience in biophparma setting Expertise in tissues/cell biology with experience in working with multiple tissue types for cell/tissue specific delivery Experience in the field of nucleic acids or antibody drug conjugates aimed at tissue specific delivery will be a plus Demonstrated scientific rigor, attention to detail and data reproducibility Excellent communication and interpersonal skills, with the ability to effectively collaborate across multidisciplinary teams.

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U.S. Pay Range $126,400.00 - $189,600.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: AboutAlnylam We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer. #J-18808-Ljbffr Alnylam Pharmaceuticals