Senior Director, Value and Access

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH. Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c). Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way. About the Role The Senior Director, Value and Access will serve as a strategic leader within Madrigal Pharmaceuticals, driving payer value communication, access strategy, and innovation across the U.S. payer landscape for therapies in Metabolic Dysfunction-associated Steatohepatitis (MASH). This role integrates traditional payer marketing responsibilities with forward-looking horizon scanning and payer innovation to ensure both near-term access success and long-term market leadership. The Senior Director is accountable for developing and executing strategic value communication platforms that clearly articulate the differentiated value of Rezdiffra to Commercial, Medicare, and Medicaid payers. This includes the creation of tailored tools and resources—payer value decks, cost-impact claims, objection handlers, and training programs—that empower field teams (NADs, RADs, KADs) to effectively communicate Madrigal's clinical and economic value story. Simultaneously, the role is responsible for proactively identifying, evaluating, and responding to emerging payer trends, competitive threats (e.g., GLP-1s, FGF21s, etc.), evolving value frameworks, and innovative reimbursement models. The Senior Director will lead initiatives to develop and pilot value-based agreements and risk-sharing strategies in collaboration with cross-functional stakeholders. Through integration of payer marketing excellence and strategic foresight, the Senior Director will ensure Madrigal maintains its first-mover advantage in MASH while preparing the organization for future payer dynamics. This position plays a critical role in shaping both current access execution and future access innovation, in alignment with brand, HEOR, and policy teams. Key Responsibilities Value Communication Strategy & Execution • Develop and execute comprehensive value communication strategies to drive payer coverage, reimbursement, and pull-through across Commercial, Medicare, and Medicaid markets. • Lead the development of payer value stories and other messaging resources supported by clinical evidence and health economics data to demonstrate the differentiated value of Madrigal’s therapies. • Integrate brand strategy into payer messaging by partnering closely with Brand Marketing to ensure alignment across patient, HCP, and payer communication channels. • Tailor value narratives to specific payer archetypes and coverage scenarios, anticipating access barriers and articulating clear justifications for formulary inclusion. • Continuously refine the overall value proposition based on evolving payer needs, policy shifts, and competitor developments. • Collaborate with HEOR and Medical to ensure alignment of payer messaging with evidence generation and scientific narratives. • Work with the commercial team to embed access and affordability messaging into HCP engagement plans and marketing tactics. • Design omnichannel content strategies that reinforce the product value proposition via digital, email, portal, journal, and conference-based touchpoints. Payer Tools & Field Enablement • Create payer engagement materials for National Access Directors (NADs), Regional Access Directors (RADs), and Key Account Directors (KADs), including objection handlers, FAQs, and scenario-based field tools. • Develop and lead training initiatives to ensure NADs, RADs, and KADs are confident in communicating the clinical and economic value of Madrigal’s therapies. Monitoring Market Evolution • Anticipate and interpret trends in U.S. payer evidence requirements. • Support the development of strategies that adapt Madrigal’s value communication in response to new competitive entrants and payer management approaches. • Serve as a strategic thought partner in identifying emerging threats and opportunities in value demonstration. • Lead proactive horizon scanning initiatives to monitor evolving payer evidence requirements, value frameworks, and reimbursement models (e.g., ICER, CMS innovation). • Analyze competitor market access strategies and pipeline disruptions (e.g., GLP-1s, FGF21s) to inform defensive positioning. • Design and pilot innovative payer engagement approaches including value-based agreements, with tailored constructs per payer archetype. • Advise internal stakeholders on forward-looking risks and strategic opportunities to sustain access leadership. Strategic Initiative Support • Collaborate with Market Access, Pricing, and Trade teams to ensure consistency and synergy across all access-related strategies. • Contribute insights and evidence inputs to strategic planning and pricing committee discussions as needed. Compliance / Governance • Ensure all payer-facing materials are accurate, fair-balanced, and compliant with legal, regulatory, and industry standards. • Collaborate with Legal, Regulatory, and Compliance teams to review and approve value communication content. About You Key Competencies & Leadership Attributes • Proven ability to synthesize clinical, economic, and market data into compelling payer narratives. • Strong understanding of U.S. payer dynamics, field access operations, and the interplay between brand and market access strategy. • Experience collaborating with commercial and field teams to drive access pull-through and payer engagement. • Proven ability to lead cross-functional teams and manage external partners/vendors. • Strong communication skills, with experience crafting messages for both internal field teams and external payer audiences. • Detail-oriented with strong project management skills and the ability to execute against tight timelines. • Strategic mindset with a proactive approach to addressing market access challenges and opportunities. Education & Experience • Advanced degree preferred (PharmD, MPH, MHA, PhD, or MBA). • Minimum 15+ years of experience in the pharmaceutical/biotech industry, with at least 5 years in payer value communications or market access. • Track record of developing impactful payer materials in support of field execution. • Therapeutic experience in metabolic, hepatic, or cardiovascular disease strongly preferred. • Experience in adjacent functions such as Market Access Strategy, Deal Evaluation, Payer Account Management, etc. highly preferred. Travel Requirement: Approximately 20% travel for cross-functional collaboration, training, and field engagement. Madrigal’s Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay, bonus and equity. Our equity offers meaningful opportunity allowing our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization. All employees receive equity, which we believe reinforces our ownership culture. Base salary is determined by several factors including the candidate’s qualifications, skills, education, experience, business needs and market demands. As of the date of this posting, a good faith estimate of the current pay scale for this position, applicable to all candidates, is $263,000 to $321,000 per year. We comply with all applicable minimum wage laws. All full-time employees receive equity, which reinforces our ownership culture and offers meaningful opportunity for our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization. Full-time employees are also eligible for comprehensive benefits, including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) offerings (i.e., traditional, Roth, and employer match) in accordance with applicable plans. We also offer additional voluntary benefits like supplemental life insurance, legal services, and other offerings. In addition, we offer mental health benefits through our Employee Assistance Program for employees and their family. The company also provides other benefits in accordance with applicable federal, state, and local laws. We are committed to providing reasonable accommodations for individuals with disabilities throughout the hiring process. If you need assistance, please contact View email address on click.appcast.io. Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law. Unsolicited resumes from agencies should not be forwarded to Madrigal. Madrigal will not be responsible for any fees arising from the use of resumes through this source. Madrigal will only pay a fee to agencies if a formal agreement between Madrigal and the agency has been established. Applications are being accepted on an ongoing basis and can be submitted through our Madrigal Careers site. Please be aware that we have received reports of individuals misrepresenting themselves as Madrigal Pharmaceuticals’ Hiring Managers, seeking to engage with job candidates through fraudulent online advertisements or job posting sites. These unauthorized individuals are using Madrigal’s name and logo in an attempt to solicit up-front fees and obtain personal information from interested job candidates. Please know that Madrigal does not conduct interviews via text or in chat rooms; conduct interviews via Skype, RingCentral or solely via telephone; charge candidates an advance fee of any kind (e.g., fees for purchasing equipment); nor does it offer positions of employment without undergoing a thorough recruiting process. Please also note that any correspondence with regard to employment would come from an authorized madrigalpharma.com email address or from an email address from one of our trusted search firm partners. We are aware that incorrect/fraudulent email addresses, with Madrigal misspelled, have been utilized in these most recent fraud attempts. If you receive unsolicited employment offers from people claiming to work for or on behalf of Madrigal, we recommend that you: do not respond to their questions; do not open any attachments; and do not click on any hyperlinks. Any questions regarding the legitimacy of job-related contacts can be directed to View email address on click.appcast.io. Join our growing team focused on transforming the treatment of people with liver diseases. Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law.