Vice President, U.S. Market Access

Key Accountabilities / Core Job Responsibilities Lead U.S. market access strategy for Denali’s portfolio, including launch and post-launch optimization for AVLAYAH and future pipeline assets. Develop integrated payer engagement, coverage, reimbursement, and patient support strategies tailored to rare disease and specialty infusion/orphan markets. Shape access strategy for accelerated approval pathways and label expansion (e.g., sBLA, lifecycle management). Partner with Commercial leadership on go-to-market strategy (patient segmentation, site-of-care, provider access). Provide executive leadership for U.S. market access functions (payer field team, patient access/experience, pricing, contracting, channel operations/strategy, government price reporting). Lead payer/pricing/policy strategy: engage commercial and government payers; execute pricing/contracting (incl. gross-to-net and value‑based where appropriate); navigate payer policies for gene/enzyme therapies, biomarkers, and surrogate endpoints; advise leadership on reimbursement risks. Evidence & value: define payer value proposition (clinical/biomarker/RWE); build HEOR models and access-focused evidence for coverage and AA‑to‑full conversion; ensure endpoints/RWE strategies are embedded in studies; support publication/value communication. Patient support: design HUB/prior authorization/affordability programs; ensure onboarding/therapy initiation; oversee compassionate use/early access; optimize patient experience. Trade/distribution/site‑of‑care: manage specialty pharmacy/distribution and site‑of‑care optimization; partner with supply chain to ensure access; align channel strategy to patient journey and payer needs. Operations/analytics: track access metrics (time‑to‑therapy, onboarding, payer approval rates); drive data‑driven optimization; lead continuous improvement. Pipeline/global alignment: partner to assess access strategy for pipeline/external assets; scale infrastructure for global expansion; align U.S. access with global evidence/regulatory where appropriate. Lead and influence cross‑functionally; serve as CMPA Leadership Team member and strategic advisor. Qualifications / Skills Bachelor’s degree and 20+ years biotech/pharma experience; senior market access leadership; 15+ years people leadership. Advanced degree (MBA/MPH/PharmD/PhD) preferred. Deep U.S. payer/reimbursement expertise for specialty/orphan drugs. Strong biomarker‑driven/surrogate endpoint understanding for payer acceptance. HEOR/RWE and value‑based access experience. Strategic + hands‑on execution; strong leadership, communication, and stakeholder management. Ability to operate in fast‑paced, evolving environments; high integrity and compliance/patient‑centric decision‑making. Experience launching therapies in rare disease, neurology, or specialty markets. Strong experience with accelerated approval, lifecycle management, and evidence‑based access strategies. Pre‑commercial/emerging biotech experience preferred. #J-18808-Ljbffr Scorpion Therapeutics