Principal Clinical Scientist

Principal Clinical Scientist What if your career's worth of clinical trial expertise could directly shape how AI understands and reasons about biomedical evidence? We're partnering with the world's leading AI research labs to build next-generation models — and we need senior clinical scientists to ensure those models get the science right. As a Principal Clinical Scientist, you'll bring regulatory-grade rigor to AI training workflows, helping frontier systems reason accurately about clinical trial design, data interpretation, and real-world evidence. Your work won't sit in a drawer — it will directly influence how AI approaches one of the most consequential domains in science. This is a fully remote, flexible contract role built for experienced clinical professionals who want to work at the cutting edge of AI without leaving their scientific roots behind. Organization: Alignerr Type: Hourly Contract Location: Remote Commitment: 10–40 hours/week Design and review clinical trial protocols used to generate high-quality, regulator-ready training datasets for AI systems Interpret and audit clinical trial results to ensure accuracy, consistency, and regulatory relevance Evaluate AI-generated clinical analyses for scientific soundness and alignment with FDA, EMA, or equivalent regulatory expectations Provide expert structured feedback that directly improves how AI models reason about clinical evidence, outcomes, and methodology Help establish quality standards for how clinical data is represented and evaluated within AI training pipelines Senior clinical scientist with hands-on experience designing clinical trial protocols for regulatory submission Deep expertise interpreting clinical data for regulatory agencies such as the FDA, EMA, or equivalent bodies Strong grounding in clinical research methodology, biostatistics, or translational science Highly detail-oriented — you catch the inconsistencies others miss and know exactly why they matter Clear and precise written communicator able to document feedback in structured, actionable formats Self-directed and comfortable working independently in an asynchronous environment Prior experience with data annotation, data quality review, or AI evaluation workflows Background in regulatory affairs, medical writing, or clinical data management Familiarity with AI tools or interest in how machine learning intersects with biomedical research Experience across multiple therapeutic areas or regulatory jurisdictions Work directly on frontier AI systems that are reshaping clinical and biomedical research Fully remote and flexible — work when and where it suits you Freelance autonomy with the structure of meaningful, technically rigorous work Influence how AI understands and evaluates real-world clinical evidence at a global scale Collaborate with leading AI research teams on problems that genuinely matter Potential for ongoing work and contract extension as new projects launch Alignerr