Lead Scientist: Amyloid Biophysics & Protein Structure
Pioneering Medicines
Flagship Pioneering seeks a Principal Scientist to build an amyloid research platform from the ground up in Cambridge, MA. This hands-on role spans protein biophysics, chemical biology, structural biology and drug discovery, producing assay-grade amyloid proteins and qualifying rigorous assays. The candidate will lead experimental strategy, train a team, coordinate CROs, and translate data into actionable insights for advancing therapies in amyloid diseases. #J-18808-Ljbffr Pioneering Medicines
- Flagship Pioneering in Cambridge, MA seeks a Principal Scientist to build FL132’s amyloid research platform from the ground up. This hands-on role interfaces protein biophysics, chemical biology, structural biology, and drug discovery to produce assay‑grade amyloid proteins...Suggested
$146k - $236.5k
...bio company, is seeking a Sr. Scientist / Principal Scientist,... ...will work at the interface of structure-based modeling and generative... ...in computational chemistry, biophysics, chemical physics, structural... ...target classes such as: GPCRs, protein-protein interactions,...Structures$163k - $214.5k
Principal Scientist, Structural Biology / Protein Biophysics Cambridge, MA USA Company Summary Flagship Labs 132 (FL1... ...Principal Scientist to help build FL132’s amyloid research platform from the ground... ...thinks critically and wants to lead the efforts to build experimental...SuggestedContract work$208k - $286k
...Principal Scientist, Machine Learning - Biomolecules... ...ML/Computational) to lead multiple AI/ML or computational... ..., systems biology, protein design, LLM/agentic... ...cheminformatics/docking/ADMET, biophysics/MD, and LLM/agentic... ..., graphs, or 3D structures; docking rescoring (e....StructuresInterim role- Metaphore Biotechnologies, Inc. is seeking a Sr. Scientist to lead the Protein Sciences team, focusing on expression, purification, and analytical characterization to support platform development and therapeutic discovery programs. The ideal candidate brings strong hands...Suggested
- C4 Therapeutics is seeking a Lead Scientist to oversee biochemical and biophysical assay strategies for the early discovery of targeted protein degraders. The role involves designing and optimizing assays to characterize protein interactions and to drive compound prioritization...
$126k - $181.5k
...antibodies. We are seeking an accomplished protein scientist and leader to run and continually... ...molecular biology, chemical engineering, structural biology, analytical chemistry, or a... ...quality and function. Experience with biophysical characterization methods such as BLI,...Structures$150k - $170k
...The company integrates deep protein engineering expertise with artificial... ...disorders. The company’s lead oncology program, RPTR-1-201,... ...is seeking a Deep Learning Scientist II to join the Artificial... ...spanning protein language models, structural modeling, and multi-modal...StructuresTemporary workWork experience placementFlexible hours- Digital Biology, Watertown MA, is hiring a Senior Scientist to lead our partnered high-throughput protein binder screening operation. You will champion standardized protocols, hands-on optimization, and end-to-end workflow management from library construction through data...
- Generate Biomedicines seeks a Senior Scientist I to lead analytical and biophysical workflows within Protein Analytics & Biophysics. You will drive stability, aggregation, and developability assessments, and guide mass spectrometry and SPR-based analyses while collaborating...
- ...Biomedicines is looking for a talented Senior Scientist I to join the Protein Analytics & Biophysics team within Protein Sciences. This role will lead and contribute to analytical... ...general mass spectrometry, proteomics, structural mass spectrometry, molecular barcoding...Shift work
$132k - $142k
...motivated and innovative Senior Scientist of Protein Sciences to join our... ...founding role will establish and lead protein science... ...Establish biochemical, biophysical, and cell-based assays to evaluate... ...Strong understanding of protein structure-function relationships, sequence...StructuresFull time- ...diverse team of AI engineers, computational scientists, and bench scientists. We hold ourselves... ...London, UK. The role You’ll engineer proteins to carry out useful chemistry, combining... ...of enzyme mechanism, kinetics, and structure-function relationships, and the ability...StructuresVisa sponsorship
$166.77k - $202.09k
...seeking an exceptional Principal Scientist to join our Small Molecule... ...excited about building a structural model as they are to build the... ..., computational biophysics, chemistry, or a related discipline... ...of biological targets (e.g., proteins, DNA, RNA) and familiarity with...StructuresHourly payFull timeSummer workLive inLocal areaRemote workFlexible hours- ...and rapid sintering to produce alloys with ultra-fine grain structures and exceptional properties. We are already deploying initial... ...you'll be working on: Foundation Alloy is seeking a R&D Group Lead Scientist to join our team. As the R&D Group Lead, you will lead a multidisciplinary...StructuresWork at officeRelocationFlexible hours
$119.7k - $222.3k
...PK Sciences representative to lead the development and use of... ...organization. Our unique organizational structure enables colleagues to work... ..., biologics/therapeutic proteins, antibody drug-conjugates,... ...be considered for Principal Scientist II. 4+ years of experience to...Structures$179k - $200k
...advance programs from hit identification to lead selection to development candidate... ...including computational chemistry, biophysics, structural biology, and biology teams to provide... ...with a talented and passionate team of scientists Be a part of a cutting-edge company that...Structures- ...Director for DNA-Encoded Library (DEL) Selection to lead DEL campaigns, design screening strategies,... ...across medicinal chemistry, biology, biophysics, structural biology, and computational chemistry, mentor scientists, and help establish best practices for DEL data...
$147k - $210k
Research Scientist, Science AI, Google Research Share Research Scientist... ...Biology, Bioinformatics, Biophysics, Physics, Computer Science,... ...: 2 years of experience leading a research agenda in computational... ...(e.g., genomics pipelines, structure prediction, physics-based...Structures- ...biology, a field focused on proteins that regulate muscle... ...scholar rock to protein structures. Our commitment to unlock... ...collaborative Senior Scientist to join the Antibody Discovery... ...advance high-quality leads through biochemical and biophysical characterization. Hands-...Structures
$80k - $95.9k
...Cancer Institute is a Structural and Chemical Biology lab... ...the pathways and protein complexes involved in... ...research team as a Cryo-EM SCIENTIST who will work on... ...crystallography, NMR), chemistry, biophysics, cellular imaging, etc... ...as needed. Takes a lead role in the...StructuresFull time- Bristol Myers Squibb is seeking a Principal Scientist for the Small Molecule Computational Design team. You will... ...that advance discovery programs, balancing structure-based and data-driven approaches. You will lead projects across multidisciplinary teams, curate data...Structures
- C4 Therapeutics is seeking a Principal Scientist, Biology (Immunology) in Watertown, MA to drive mechanism-based immunology programs using our TORPEDO platform and lead targets from discovery through IND-enabling studies. You will work with primary human immune cells and...
- ...through late clinical development. Our unique organizational structure enables colleagues to work seamlessly in the translational and... ...role potentially includes small molecules, biologics/therapeutic proteins, antibody drug-conjugates, radioligand therapies and/or cell...Structures
- ...Proteomics Scientist Location: This role is based in-person at... ...proximity therapeutics by making protein interactions programmable.... ...collaborations across the world’s leading biopharma and tech... ...that combines state-of-the-art structure prediction and molecular generation...Structures
$175k - $225k
...biology, a field focused on proteins that regulate muscle mass, the... ...of a scholar rock to protein structures. Our commitment to unlock fundamentally... ...collaborative Principal Scientist, Biomarker Development, to... ...Leadership Develop and lead biomarker strategies for neuromuscular...Structures$90k
...intersection of nanopore sensing, protein analysis, polymer-enabled... ...collaborators, including leading researchers in polymer chemistry... ...relationships between molecular structure, nanopore transport behavior,... ...Engineering, Nanotechnology, Biophysics, Biomedical Engineering,...Structures$108.5k - $201.5k
Principal Scientist - Analytics Team Lead Job ID REQ-10082679 Oct 04, 2026 USA Summary The Biologics Research Center (BRC) at Novartis BioMedical... ...a diverse biologics pipeline (e.g. antibodies, fusion proteins, ADCs, bi- and trispecifics, AAVs, Lentiviruses) transitioning...- Repertoire Immune Medicines is seeking a Deep Learning Scientist II to join the Artificial Immune Intelligence Team to accelerate... .... The role focuses on developing DL methods spanning protein language models and structure-prediction, collaborating with wet-lab scientists in a...Structures
- ...intellectually agile scientist to join our stealth-mode... ...-functional team to lead candidate optimization... ...selected RNA-based and protein-based assays to support... ...using biochemical, biophysical, and cell-based assays... ...affinity maturation, and structure-activity relationships...Structures
Do you want to receive more vacancies?
Subscribe and receive similar vacancies to Lead Scientist: Amyloid Biophysics & Protein Structure. Be the first to apply!
- genomics scientist Cambridge, MA
- principal scientist Cambridge, MA
- scientist 1 Cambridge, MA
- bioanalytical scientist Cambridge, MA
- applied scientist Cambridge, MA
- decision scientist Cambridge, MA
- health scientist Cambridge, MA
- graduate scientist Cambridge, MA
- hplc scientist Cambridge, MA
- image scientist Cambridge, MA



