Senior Medical Director, Clinical Development Rare Cardiology

The Senior Medical Director Clinical Development will lead the clinical team for a high-visibility program and report to the Global Clinical Head. This is an excellent opportunity for an experienced and motivated drug developer to advance an innovative, late-stage study. The SD will provide medical leadership across late stage. Acting as a key medical expert on the study team(s), the SD may also serve as medical monitor as needed. In this role, the SD will work cross-functionally and mentor Physicians, Clinical Directors, and Clinical Development Scientists. The position may include direct and indirect managerial responsibilities for team members across the Clinical Development organization. The SD will also contribute to the development of regulatory, therapeutic area, and functional strategies. This position offers the opportunity to collaborate closely with enterprise-level, cross-functional teams, including AstraZeneca Business Units, CVRM, and strategic development partners. The ideal candidate will thrive in a fast-paced, proactive, and collaborative culture—demonstrating strong communication skills, scientific leadership, and the ability to drive impact across both internal and external teams. You will be responsible for: Lead cross-functional clinical program teams to deliver high-quality studies and research strategies, ensuring scientific rigor and optimal benefit–risk management. Serve as the clinical authority for assigned programs, overseeing study design, execution, data interpretation, and regulatory deliverables in compliance with GCP. Provide strategic medical and scientific input across R&D, translational science, commercial, and business development activities, including due diligence and collaborations. Mentor and develop Medical Directors, Clinical Development Scientists, and fellows to build organizational scientific and leadership capability. Represent the program internally and externally through governance presentations, regulatory interactions, scientific publications, and engagement with key opinion leaders. You will need to have: MD with specialty training in Internal Medicine. 7+ years of experience in clinical development; clinical research, global regulatory, and product development expertise Has prepared documents and attended regulatory meetings with FDA and other regulatory agencies. Experience designing and executing multinational clinical trials required Demonstrated ability to lead cross-functional teams to define clinical strategy and clinical study design. Experience supporting business development activities. Ability to learn rapidly, think critically, and operate effectively in a fast-paced environment. The duties of this role are generally conducted in an office environment. As is typical of an office-based role, employees must be able, with or without an accommodation to: use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving and non-linear thought, analysis, and dialogue; collaborate with others; maintain general availability during standard business hours. We would prefer for you to have: Board Certification. Experience in ATTR amyloidosis Preferred: Advanced knowledge of the assigned therapy area is desired, with the capability to interpret, discuss and represent trial or program level data. PhD in related discipline desirable. Experience with BLA/MAA submissions. Demonstrated experience as a clinical trialist with a strong external network, including relationships with key investigators, sites, and patient partners. Experience operating at the clinical-commercial interface and shaping clinical strategies with commercial insight. Broad awareness of the global therapeutic landscape and regulatory environment within rare or cardiometabolic diseases. Willingness and ability to travel nationally and internationally. Working at AlexionWe’re inspired to think differently, to create better outcomes. By creating an unparalleled employee experience, our organization is equipped to adapt and enrich employees with a productive, engaging, and enjoyable work experience, while accelerating world-class leadership and innovation capabilities that can deliver on our mission. Each of us is accountable for delivering innovative medicines and supportive technology with integrity so we can truly understand and better the lives of people affected by rare diseases. Together, we can transform lives every day The Highest Standards By operating with the highest standards of ethics and integrity, we aspire to live up to the expectations of patients, physicians, and ourselves, and to earn trust in our communities. Diversity We encourage diversity of backgrounds and ideas. We genuinely care for and respect each other, working together as a high-performing team to deliver extraordinary results while embracing different perspectives. Dedication The dedication and passion of our employees enable us to stay focused on what matters most. We push ourselves to achieve the highest level of medical innovation, and to redefine what it means to live with a rare disease. In-Office Hybrid This role has an expectation of working in the office a minimum of 3 days a week. When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. Inperson working give us the platform we need to connect, work at pace and challenge perceptions. That’s why we work, on average, a minimum of three days per week from the office. But that doesn’t mean we’re not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics.We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.Alexion is proud to be an Equal Employment Opportunity and Affirmative Action employer. We are committed to fostering a culture of belonging where every single person can belong because of their uniqueness. The Company will not make decisions about employment, training, compensation, promotion, and other terms and conditions of employment based on race, color, religion, creed or lack thereof, sex, sexual orientation, age, ancestry, national origin, ethnicity, citizenship status, marital status, pregnancy, (including childbirth, breastfeeding, or related medical conditions), parental status (including adoption or surrogacy), military status, protected veteran status, disability, medical condition, gender identity or expression, genetic information, mental illness or other characteristics protected by law.The annual base pay for this position ranges from 280,895.20 to 421,342.80 USD Annual . Our positions offer eligibility for various incentives—an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans.Date Posted30-Jul-2026Closing Date12-Aug-2026Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.SummaryLocation: US - Boston - MAType: Full time