Senior Director, Clinical Pharmacology
Centessa Pharmaceuticals
Role: Senior Director, Clinical Pharmacology (Translational) at Centessa Pharmaceuticals, providing strategic leadership across neuroscience drug development from early to late stages, focusing on CNS exposure, dose optimization, and translational biomarkers. Responsibilities develop and execute clinical pharmacology strategies; lead model-informed drug development including PK/PD and exposure-response analyses; oversee clinical pharmacology studies (FIH, DDI, biopharmaceutics); author regulatory documents and interact with health authorities; partner with cross-functional teams (DMPK, Clinical Development, Biomarkers, Regulatory); manage CROs and external vendors; mentor pharmacology talent. Qualifications PhD/MD/PharmD in relevant discipline; 8–12+ years in biopharma with impact in translational science; expertise in PK, PD, modeling tools (NONMEM, Phoenix WinNonlin, SimCyp); experience in early-to-late stage and regulatory submissions; strong understanding of CNS exposure and biomarkers; excellent communication and leadership skills. High-value: neuroscience, CNS, translational pharmacology, biomarker integration, regulatory engagement, remote work with occasional travel. #J-18808-Ljbffr Centessa Pharmaceuticals
Vacancy posted 5 days ago
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