Principal Scientist

Principal Scientist, Protein Sciences, Analytical Characterizations

September 2025

Department: Technology

Position Summary:

TCG Labs-Soleil is seeking a highly experienced and driven Principal Scientist to lead our analytical efforts and join our multidisciplinary Protein Sciences group within the biologics Technology team. This critical role will lead the developability assessment efforts for our biologics research programs. They will design, execute, and interpret analytical and biophysical characterizations in support of a diverse protein and antibody focused pre-clinical therapeutic pipeline. The ideal candidate will have a proven track record of leading complex R&D projects, mentoring research scientists, and contributing to the strategic direction of the Protein Sciences group. This candidate will have a ‘can-do’ attitude and lead from the bench.

Responsibilities:

• Design, develop, and implement analytical methods for the characterization ofdiverse biologicswith an emphasis on LC-MS and biophysical characterization to drive discovery programsthrough the research pipeline.
• Establish and validate robust biophysical assays to characterize therapeutic biologics (monoclonal antibodies, bispecific antibodies, fusion proteins, etc.)
• Design and execute experiments,make detailed observations, analyze and interpret data, and deliver results in a concise and timely manner to the team.
• Manage CROs and external collaborations on analytical development.
• Prepare precise technical summaries, protocols, and maintain appropriate documentation.
• Deliver concise data summaries to leadership and ensure clear communication with the development team.
• Lead program analytics efforts to support program progression.
• This is a full-time and lab-based position.

Qualifications:

• Ph.D. (or equivalent) in biochemistry, biophysics, analytical chemistry, or a related field, offering 10+ years of monoclonal and multispecific antibody characterization experience in biotech or startup environments.
• Demonstrated leadership managing scientific teams and mentoring direct reports to drive performance and growth.
• Deep technical expertise in biophysical methods, including HPLC, CE, SPR, DSF, DSC, SEC-MALS, and LC-MS.
• Strong foundation in protein analytics, with extensive hands-on PTM characterization of biologic therapeutics.
• Proven track record in developability studies across monoclonal & multispecific antibodies, fusion proteins, and antibody-drug conjugates (ADCs).
• Comprehensive understanding of biologics drug discovery—from hit-to-lead through lead optimization to candidate selection stages.
• Research-driven mindset with a clear orientation toward translating findings to deliver therapeutic solutions.
• Experienced in CMC development processes and contributing to IND filing initiatives (highly desirable).
• Meticulous in data organization, adept at managing multiple projects simultaneously while maintaining high standards of quality.
• Exceptional written and oral communication skills for clear presentation of complex scientific data.
• Flexible team collaborator, rapidly adapting to new scientific domains and mastering new techniques.
• Proven ability to thrive and achieve results in fast-paced, dynamic, multitasking environments.

Company Overview

TCG Labs-Soleil, established in partnership with The Column Group , a science-focused venture capital firm, is pioneering a novel ‘venture capital-biotech’ model. Our core mission is to efficiently translate scientific insights into therapeutic solutions for patients facing serious diseases. This model supports scientific entrepreneurs from the initial idea to clinical proof of concept (PoC) by combining a dedicated fund (TCG Labs) with our independent, evergreen R&D center led by a top-tier scientific team (Soleil). Together, we create an integrated ecosystem that fosters the development of single-asset portfolio companies, strategically poised for transacting after clinical PoC.
For more details, visit TCGLSoleil.com and follow us on LinkedIn

EEO Statement TCG Labs-Soleil is an Equal Opportunity Employer. We do not discriminate against qualified applicants based upon any protected group status, including but not limited to race, religion, color, creed, sex (including breastfeeding and related conditions), gender identity/gender expression, pregnancy (including childbirth and related conditions), national origin, ancestry, age, marital status, military or veteran status, sexual orientation, genetic information, physical or mental disability or medical condition as defined by applicable equal opportunity laws. Any request for accommodation can be directed to View email address on click.appcast.io.

Benefits and Compensation TCG Labs-Soleil provides a competitive benefits package that includes access to Medical, Dental, and Vision Insurance, Life Insurance, Short and Long Term Disability, Health Savings Account (HSA), Flexible Spending Accounts (FSA), 401k plan and PTO.

The anticipated salary range for fully qualified candidates applying for this role will be $140,000 - $250,000 annually (not including discretionary bonus, equity, and benefits). The final salary offered will be dependent on several factors that include but are not limited to relevant previous experience including duration and type of experience within the industry, education, and internal equity.

Staffing Agencies TCG Labs-Soleil does not accept unsolicited agency resumes and will not pay fees to any third-party agency or firm that doesn’t have a signed agreement with TCG Labs-Soleil. Please do not send agency CVs/resumes through TCG Labs-Soleil website or TCG Labs-Soleil Employees. Inquiries must be sent to View email address on click.appcast.io with the Subject Heading: Staffing Agency Request.