Principal Scientist, Translational Clinical Biomarkers

Role Principal Scientist providing strategic biomarker leadership within cardiovascular, metabolic, infectious diseases, and vaccines portfolios, supporting early to late clinical development. Responsibilities develop integrated biomarker strategies aligned with therapeutic mechanisms, disease biology, and clinical endpoints; translate scientific hypotheses into decision-enabling approaches; interpret complex biomarker and clinical data; collaborate across Discovery, Clinical, Data Science, Regulatory, and Operations teams; mentor biomarker scientists and support scientific communications and publications. Requirements Ph.D., M.D., or equivalent in translational medicine, biomarker science, or related field; extensive experience in translational/clinical biomarker strategy development in drug/vaccine development; strong understanding of disease mechanisms, pharmacodynamics, and clinical endpoints; proven ability to lead cross-functional teams in a matrix environment; excellent data analysis, scientific communication, and strategic planning skills. Preferred experience in cardiovascular, metabolic, infectious disease, or vaccine programs; familiarity with pharmacodynamic, predictive, or precision-medicine biomarkers; mentoring experience. High-Value leadership in biomarker development across clinical phases, focus on high-value, interpretable evidence, and integration of complex datasets to inform program decisions. Work setup hybrid remote, with approximately 10% travel. #J-18808-Ljbffr Merck