Research Technician

Company Description

TrAMPoline Pharma, Inc. is a cancer-focused cell therapy company developing personalized therapies for solid tumor cancers. The company’s lead candidate, MightyTIL™, uses proprietary technology to produce engineered Tumor Infiltrating Lymphocytes (TIL) with enhanced anti-tumor activity. TrAMPoline Pharma is dedicated to advancing innovative immunotherapies to improve patient outcomes in challenging oncology indications. Team members collaborate in a science-driven environment that values rigorous research, quality, and continuous learning. The company offers opportunities to contribute directly to the development of next-generation cell therapies.

Role Description

The Research Technician is a full-time, on-site role based in Aurora, CO. This role supports preclinical and translational research activities related to the development and optimization of cell therapy programs. Day-to-day responsibilities include performing experiments involving cell engineering of human T cells, in vitro T cell functional assays, and in vivo tumor control experiments. The Research Technician will assist with experimental design, collect and record data in electronic systems, and contribute to data analysis and interpretation. Additional duties include equipment maintenance, inventory management, adherence to safety and biosafety guidelines, and close collaboration with cross-functional team members. A successful candidate will bring strong technical skills and scientific curiosity .

Qualifications

• Relevant educational background such as a Bachelor’s or Master's degree in biology, immunology, or a related field.
• Strong research and analytical skills, including the ability to follow experimental protocols, troubleshoot issues, and interpret scientific data.
• Core laboratory skills such as pipetting, solution preparation, use of common lab equipment, and strict adherence to safety, quality, and documentation standards.
• Hands-on experience with tissue culture techniques, including aseptic handling, cell expansion, and monitoring of cell health and viability. Experience handling human T cells is preferred.
• Competence in data analysis, including organizing data, using statistical methods/software, and clearly documenting and presenting findings.
• Strong understanding of experimental controls and interpretation of biological data.
• Ability to work collaboratively in a team-based environment, follow detailed instructions, manage time effectively, and maintain meticulous records.
• Familiarity with oncology, immunology, or cell therapy research is beneficial; prior experience in industry or regulated laboratory settings is a plus.
• Experience with T cell engineering, viral transduction, cell manufacturing workflows, tumor implantation, tumor monitoring, and tissue collection are beneficial.

Responsibilities

• Execute experiments using primary human T cells and other immune cell populations, including isolation, activation, genetic modification, expansion, cryopreservation, and recovery.
• Perform T cell functional assays to evaluate activation, proliferation, cytokine production, cytotoxicity, persistence, and other relevant phenotypes.
• Optimize and troubleshoot flow cytometry-based assays, including immunophenotyping and intracellular cytokine staining.
• Execute mouse studies to evaluate safety and efficacy of cell therapy candidates. Perform tumor engraftment, cell therapy administration, animal monitoring, tissue collection, and downstream sample processing.
• Communicate results clearly through experimental summaries, figures, presentations, and reports.
• Maintain laboratory readiness, including cell cultures, reagents, equipment, and experimental materials.

Why Join TrAMPoline Pharma, Inc

At TrAMPoline Pharma, Inc, you will have the opportunity to work directly on the biology underlying novel cell therapies and see your experiments influence program strategy. This is a high-ownership, low-bureaucracy environment where scientists are expected to contribute ideas, build capabilities, troubleshoot, and take experiments from hypothesis through interpretation. You will work alongside a small team with expertise in cell therapy, immunology, translational research, and development, with significant opportunity to shape our programs.

TrAMPoline Pharma, Inc is an equal opportunity employer.

The annual salary range for this role is $55,000-$75,000. This is the range that we in good faith believe is the range of possible compensation for this role at the time of this posting. This range may be modified in the future. We offer benefits including paid time off and 401(k) to eligible employees. Applicants must be legally authorized to work in the United States without requiring sponsorship. We are unable to provide work visa sponsorship or employment authorization for this position.