Principal Scientist, Medicinal Chemistry

Job Summary

We seek an experienced and creative medicinal chemist with a proven track record of success in drug discovery. Candidates should be motivated to work in an intensely collaborative, multidisciplinary, team‑based setting. The ideal candidate will be passionate about solving medicinal chemistry challenges and proactively interfacing with diverse teams working on automated experimentation, AI‑driven molecular generation, property predictions, and bioassay data generation. This position is on‑site at our San Diego Headquarters.

Key Responsibilities

• Devise strategies to identify lead molecules and optimize them for potency, selectivity, and ADME properties using multivariant SAR analysis and hypothesis‑driven design principles.
• Execute high‑quality ideas by employing a broad range of modern organic chemistry transformations, synthetic methods, creative use of parallel experimentations, and implementing innovative techniques.
• Work closely with molecular and cellular biology, pharmacology, computational chemistry, ADME, and other key functions.
• Influence the prospective use of computational methods and leverage automated synthesis and high‑throughput experimentation capabilities.
• Work closely with AI/ML teams to develop and implement relevant predictive models to aid in the design of new molecules.
• Communicate project updates clearly and effectively to the broader team and key stakeholders.
• Work as a member of the Chemistry research group and foster a culture of scientific excellence, innovation, and teamwork.

Qualifications

• BS, MS, or PhD in chemistry with a focus on synthetic organic chemistry.
• Experience in small‑molecule drug discovery in a biotechnology or pharmaceutical setting; B.S. with 15+ years, M.S. with 12+ years, or Ph.D. with 8+ years of experience.
• Proven track record of success in advancing programs from leads to advanced candidates.
• Extensive experience in lead compound optimization for potency, selectivity, ADME, and PK.
• Expert in modern synthetic organic chemistry approaches and principles, demonstrated through publications in journals and patents.
• Practical experience and working knowledge of target protein degradation and associated modalities (molecular glues, PROTACs).
• Ability to integrate multiple R&D disciplines into a successful strategic project plan.
• Experience working with computational chemists as part of a project team in the design of drug targets.
• Strong interpersonal, communication, time‑management, and leadership skills.
• Creative problem solving and management of relationships with several stakeholders within and beyond the company.

Pay And Benefits

We offer industry-leading competitive pay, company‑paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation. Compensation Range: $152 K – $190 K.