Molecular Biologist II

DSHS is committed to hiring skilled and dedicated individuals who share a passion for public health to pursue our vision of A Healthy Texas. If you are looking to make an impact and tackle new challenges, we encourage you to consider a career with us.

Employee Benefits:

DSHS offers insurance coverage and other benefits available through the State of Texas Group Benefits Plan administered by the Employee Retirement System of Texas (ERS). To learn more about all the benefits available to you as a DSHS employee and other DSHS opportunities for early career pathways, visit the DSHS Careers Page.

Review our Top 10 Tips for Success when Applying to State of Texas Jobs.

Functional Title: Molecular Biologist II
Job Title: Molecular Biologist II
Agency: Dept of State Health Services
Department: NBS/Med Scrning QI/Test Supp
Posting Number: 20552
Closing Date: 09/09/2026
Posting Audience: Internal and External
Occupational Category: Life, Physical, and Social Science
Salary Range: $4,565.12- $5,249.89
Pay Frequency: Monthly
Salary Group: TEXAS-B-19
Shift: Regular Weekend Day
Additional Shift:
Telework:
Travel:
Regular/Temporary: Regular
Full Time/Part Time: Full time
FLSA Exempt/Non-Exempt: Nonexempt
Facility Location:
Job Location City: AUSTIN
Job Location Address: 1100 W 49TH ST (DBGL)
Other Locations:
MOS Codes: 230X,43BX,43TX,71A,SEI12

Brief Job Description:

Under the supervision of the Newborn Screening Molecular Branch Manager, uses considerable knowledge to independently perform highly complex advanced molecular genetic procedures (including DNA extraction, electrophoresis, polymerase chain reaction (PCR), real-time PCR, automated DNA sequencing, and DNA sequence analysis) to identify mutations causing spinal muscular atrophy, cystic fibrosis, sickle cell disease, medium chain acyl-CoA dehydrogenase deficiency, galactosemia, and other NBS disorders using standardized procedures developed in the DNA Analysis Team. Responsible for making significant decisions on the accuracy of laboratory tests on human specimens. Independently determines and troubleshoots complex results based on Standard Operating Procedures (SOP). Performs the equipment maintenance and troubleshooting, specimen and reagent preparation, clean-up, and other supporting work for the laboratory. Performs quality control (QC) for DNA studies and utilizes considerable working knowledge of all procedures to participate in maintaining analytic accuracy and continuity of testing. Performs computer database searches, specimen login and record-keeping of results. Actively participates in the safety program. Duties are independently performed with considerable latitude, adherence to standard protocol, and with use of scientific knowledge and independent judgment. Work hours/days and laboratory assignments may vary; all staff members will be required to work on Saturday as part of a rotating schedule.

Essential Job Functions (EJFs):

Attends work on a regular and predictable schedule in accordance with agency leave policy and performs other duties as assigned.

EJF 1. Performs highly complex advanced molecular genetic procedures including DNA extraction, electrophoresis, PCR, real-time PCR, RFLP analysis, DNA sequencing, and DNA sequence analysis following laboratory protocol guidelines for the identification of mutations causing spinal muscular atrophy (SMA), cystic fibrosis, hemoglobinopathies, medium chain acyl-CoA dehydrogenase deficiency, galactosemia, and other NBS disorders. Evaluates and makes preliminary interpretations of highly complex data. (50%)

EJF 2. Follows QC guidelines and monitors the reagents, materials, and assays to ensure accuracy and continuity of testing. Completes all required QC documentation accurately and in a timely manner. (10%)

EJF 3. Ensures proper specimen receipt, storage and tracking of location and testing status. Ensures accurate entry of patient demographic information and test results. Uses computer software (e.g., Microsoft Word, Excel, PowerPoint, laboratory information system, etc.) to maintain laboratory testing records for reporting and data presentations. (10%)

EJF 4. Performs and documents the preparatory and other supporting work for DNA testing. Prepares reagents, controls, reaction tubes, tips and other material needed in the laboratory. (5%)

EJF 5. Performs equipment maintenance and troubleshooting. Cleans and maintains the automated DNA sequencer replacing reagents as needed. Cleans glassware, laboratory equipment and bench surface as required. Disposes of chemical and biological waste following practices in compliance with regulations. Completes all required documentation accurately and in a timely manner. (10%)

EJF 6. Promotes workflow through cooperative interaction, reassignment of duties, and teamwork with supervisors, co-workers, and internal and external customers. Initiates rapid communication of abnormal test results to team leader. Conducts training as required. Other duties as assigned include but are not limited to actively participating and/or serving in a supporting role to meet the agency’s obligations for disaster response and/or recovery or Continuity of Operations (COOP) activation. Such participation may require an alternate shift pattern assignment and/or location. Based on your work area, consistently comply with DSHS Laboratory, local, state and federal guidelines to ensure a safe functioning laboratory. (5%)

EJF 7. Performs computer database searches to obtain information pertinent to laboratory testing. Uses computer databases for literature searches, genetic disease information and DNA sequence queries. Assists with preparing complex technical reports and research papers. Assists in research, evaluation, development, and implementation of new testing procedures. (5%)

EJF 8. Recognizes delays in completion of specimen testing, result reporting, and other essential functions and notifies the supervisor immediately. Identifies problems with atypical test results recommending solutions and consulting with upper-level personnel. (5%)

Knowledge, Skills and Abilities (KSAs):

• General knowledge of laboratory, quality control, and human molecular genetic principles, techniques, and terminology.

• Knowledge of laboratory safety including sample-handling techniques.

• Ability to communicate effectively orally and in writing.

• Ability to follow written and verbal instructions.

• Ability to use various items of laboratory equipment associated with work area.

• Ability to use a computer, including data base searches.

• Ability to interact effectively with staff.

• Ability to work in harmony with other team members.

• Ability to work as part of a team adhering to structured deadlines for completion of critical laboratory procedures.

• Ability to lead co-workers by setting a positive work-ethic example.

• Ability to follow standard operating procedures and protocols accurately.

• Ability to keep accurate, detailed records.

• Ability to use aseptic techniques when working with infectious material.

• Ability to complete tasks without close supervision and use mature judgment in test interpretation.

• Ability to prioritize and organize detailed tasks to maintain required section timeframes.

• Ability to recognize and solve work area problems.

• Ability to maintain work area instruments and automated testing equipment.

• Ability to teach work area procedures to co-workers and guests.

• Ability to prepare diagnostic (analytical) reagents and/or controls accurately.

• Skill to manipulate standard laboratory equipment with speed, accuracy, and safety.

• Ability to visually distinguish color differences as required for testing procedures.

Registrations, Licensure Requirements or Certifications:

N/A

Initial Screening Criteria:

Have an earned bachelor’s, master’s, or doctoral degree in a chemical, physical, biological or clinical laboratory science or medical technology from an accredited institution.

Ability to work on Saturdays on rotating basis required.

Minimum 2 years of molecular testing experience or 1 year of clinical molecular testing experience required.


Preferred but not required:
Experience with clinical molecular laboratory testing procedures in newborn screening.

Experience in a high-volume workload laboratory setting.

Additional Information:

Hepatitis Risk High. Required Hepatitis B and Tetanus/Diphtheria immunizations are provided. Must wear provided personal protective equipment (including: face shield, gloves, laboratory coat, safety glasses) as required by testing/ safety procedures.


Interviews scheduled after screening. Must be able to pass a functional color vision assessment in order to carry out essential job functions. The functional color vision assessment will be administered at the time of the interview.


Work hours/days and laboratory assignments may vary, all staff members will be required to work on Saturday as part of a rotating schedule. Shift differential for Saturday rotation applies per DSHS policy.

College transcripts are required.

Active Duty, Military, Reservists, Guardsmen, and Veterans:

Military occupation(s) that relate to the initial selection criteria and registration or licensure requirements for this position may include, but not limited to those listed in this posting. All active-duty military, reservists, guardsmen, and veterans are encouraged to apply if qualified for this position. For more information see the Texas State Auditor’s Military Crosswalk at

ADA Accommodations:

In compliance with the Americans with Disabilities Act (ADA), DSHS will provide reasonable accommodation during the hiring process for individuals with a qualifying disability. If reasonable accommodation is needed to participate in the interview process, please notify the person who contacts you to schedule the interview. If you need assistance completing the on-line application, contact the HHS Employee Service Center at View phone number on aiapply.co or via email at View email address on aiapply.co.

Salary Information, Pre-employment Checks, and Work Eligibility:

• The salary offered will follow DSHS starting salary guidelines. Any employment offer is contingent upon available budgeted funds.
• Depending on the program area and position requirements, applicants selected for hire may be required to pass background and other due diligence checks.
• DSHS uses E-Verify. You must bring your I-9 documentation with you on your first day of work. Download the I-9 form