RESEARCH FELLOW

Mission Statement The Life Sciences Institute explores biological processes, structures, and functions at the finest scale to create impact on a global scale. The Mosalaganti lab at the Life Sciences Institute (LSI) is looking for an outstanding postdoctoral research fellow interested in applying multimodal imaging workflows and multi-omics analyses to understand cell biology of lysosomal heterogeneity. You will have unencumbered access to our state-of-the‑art light and electron microscopy on‑site and various excellent core facilities at the University of Michigan. You should have the following: (1) a strong background in computational biology/cell biology/neurobiology . (2) a sense of independence, and (3) be motivated to push the boundaries of cell biology. You will report directly to Dr. Mosalaganti and perform your work onsite at the LSI. Responsibilities* Experimental responsibilities will include: Identifying and characterizing proteins responsible for lysosomal susceptibility and resilience in models of neurodegeneration. Conduct biochemical assays including western blot, transcriptomics, immunoprecipitation of proteins and organelles (e.g., lysosomes), quantitative proteomics analyses, fluorescence microscopy, and in vivo / in vitro enzyme assays. Maintain and amplify iPSC-derived neurons, microglia, and astrocytes and analyze physiological and biochemical data from brain tissue samples. Generate brain organoids and assembloids. Non-Experimental responsibilities will include: Work with PI to apply for independent research funding. Work/collaborate with other postdoctoral fellows and graduate students in and outside of the laboratory. Mentor undergraduates and graduate students in the laboratory. Assist PI with writing manuscripts and grants. Required Qualifications* Ph.D. in cell biology, neurobiology, genetics, or related discipline Minimum of 2 years of experience with light and confocal microscopy (imaging/data processing) Minimum of 2 years of experience with primary cultures or stem cells Familiarity with CRISPR/Cas9 and molecular biology/cloning 2 years of experience in analyzing 'omics' datasets Ability to work independently and as a team player Desired Qualifications* Minimum 2 years of experience in organellar biology, specifically the endolysosomal system 1-2 years of experience in generating cortical/cerebral organoids Modes of Work Positions that are eligible for hybrid or mobile/remote work mode are at the discretion of the hiring department. Work agreements are reviewed annually at a minimum and are subject to change at any time, and for any reason, throughout the course of employment. Learn more about the work modes . Additional Information Recent graduates or students finishing their graduate studies this year/early next year can apply for an exciting fellowship through the Michigan Life Science Fellowship program ( ). Pursuant to University policy, postdoctoral research fellow appointments should be for one year or less, with the possibility of renewal in subsequent years, not to exceed a total of five years of postdoctoral training at the University. Benefits at the University of Michigan: The University of Michigan offers a comprehensive benefits package to help you stay well, protect yourself and your family and plan for a secure future. Benefits include: Many choices for comprehensive health insurance Dental and Vision Insurance Life insurance Flexible spending accounts for healthcare and dependent care expenses Maternity and Parental Leave The University of Michigan conducts background checks on all job candidates upon acceptance of a contingent offer and may use a third party administrator to conduct background checks. Background checksare performed in compliance with the Fair Credit Reporting Act. Application Deadline Job openings are posted for a minimum of seven calendar days.The review and selection process maybegin as early as the eighth day after posting.Thisopening may be removed from posting boards and filled any time after the minimum posting period has ended. U-M EEO Statement The University of Michigan is an Equal Opportunity Employer. We are committed to providing an environment of mutual respect where equal employment opportunities are available to all applicants, including protected veterans and individuals with disabilities. #J-18808-Ljbffr University of Michigan